Results 21 to 30 of about 4,508 (221)
Deficient methylation and formylation of mt-tRNA(Met) wobble cytosine in a patient carrying mutations in NSUN3. [PDF]
, 2016 Epitranscriptome modifications are required for structure and function of RNA and defects in these pathways have been associated with human disease.
Blanco, Sandra +18 more
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Flavin-dependent epitranscriptomic world [PDF]
Archives of Biochemistry and Biophysics, 2017 RNAs molecules fulfill key roles in the expression and regulation of the genetic information stored within the DNA chromosomes. In addition to the four canonical bases, U, C, A and G, RNAs harbor various chemically modified derivatives which are generated post-transcriptionally by specific enzymes acting directly at the polymer level.
Lombard, Murielle, Hamdane, Djemel
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RNA Modification Related Diseases and Sensing Methods
Applied Sciences, 2023 Epitranscriptomics is the study of RNA base modifications, including functionally relevant transcriptomic changes. Epitranscriptomics has been actively studied in recent years and has been reported to play important roles in development, homeostasis, the
Mayuka Ohkawa, Masamitsu Konno
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Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method. [PDF]
, 2016 Adenosine deamination is one of the most prevalent post-transcriptional modifications in mRNA. In humans, ADAR1 and ADAR2 catalyze this modification and their malfunction correlates with disease. Recently our laboratory reported crystal structures of the
Beal, Peter A, Wang, Yuru
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World Journal of Clinical Oncology, 2018 The functional impact of modifications of cellular RNAs, including mRNAs, miRNAs and lncRNAs, is a field of intense study. The role of such modifications in cancer has started to be elucidated. Diverse and sometimes opposite effects of RNA modifications have been reported.
Tusup, Marina +2 more
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BMC Bioinformatics, 2019 Background Over one hundred different types of post-transcriptional RNA modifications have been identified in human. Researchers discovered that RNA modifications can regulate various biological processes, and RNA methylation, especially N6 ...
Xiangyu Wu +7 more
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m6a RNA methylation: the implications for health and disease [PDF]
, 2014 The recent resurgence of interest in m6a has been spurred by some intriguing findings detailing the effects and dynamics of this epigenetic modification.
McGuinness, D., Mcguinness, D.H.
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tRNA epitranscriptomics and biased codon are linked to proteome expression in [PDF]
, 2018 Among components of the translational machinery, ribonucleoside modifications on tRNAs are emerging as critical regulators of cell physiology and stress response. Here, we demonstrate highly coordinated behavior of the repertoire of tRNA modifications of
Aniweh, Yaw +8 more
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HIV Modifies the m6A and m5C Epitranscriptomic Landscape of the Host Cell [PDF]
, 2021 The study of RNA modifications, today known as epitranscriptomics, is of growing interest. The N6-methyladenosine (m6A) and 5-methylcytosine (m5C) RNA modifications are abundantly present on mRNA molecules, and impact RNA interactions with other proteins
Angelino, Paolo +4 more
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The Arabidopsis epitranscriptome
Current Opinion in Plant Biology, 2015 The most prevalent internal modification of plant messenger RNAs, N(6)-methyladenosine (m(6)A), was first discovered in the 1970s, then largely forgotten. However, the impact of modifications to eukaryote mRNA, collectively known as the epitranscriptome, has recently attracted renewed attention.
Fray, Rupert G., Simpson, Gordon G.
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