Results 31 to 40 of about 547,775 (258)

Chemical Modifications of Ribosomal RNA

, 2022
AbstractCellular RNAs in all three kingdoms of life are modified with diverse chemical modifications. These chemical modifications expand the topological repertoire of RNAs, and fine-tune their functions. Ribosomal RNA in yeast contains more than 100 chemically modified residues in the functionally crucial and evolutionary conserved regions.
Sunny, Sharma, Karl-Dieter, Entian
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The regulatory role of N6-methyladenosine RNA modification in gastric cancer: Molecular mechanisms and potential therapeutic targets

Frontiers in Oncology, 2022
N6-methyladenosinen (m6A) methylation is a frequent RNA methylation modification that is regulated by three proteins: “writers”, “erasers”, and “readers”. The m6A modification regulates RNA stability and other mechanisms, including translation, cleavage,
Gaofeng Li, Qiru Fu, Cong Liu, Yuxi Peng, Jun Gong, Shilan Li, Yan Huang, Haiyuan Zhang   +7 more
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mRNA Regulation by RNA Modifications

Annual Review of Biochemistry, 2023
Chemical modifications on mRNA represent a critical layer of gene expression regulation. Research in this area has continued to accelerate over the last decade, as more modifications are being characterized with increasing depth and breadth. mRNA modifications have been demonstrated to influence nearly every step from the early phases of transcript ...
Gilbert, Wendy V., Nachtergaele, Sigrid
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Characterization of N6-methyladenosine long non-coding RNAs in sporadic congenital cataract and age-related cataract [PDF]

International Journal of Ophthalmology
AIM: To characterize the N6-methyladenosine (m6A) modification patterns in long non-coding RNAs (lncRNAs) in sporadic congenital cataract (CC) and age-related cataract (ARC).
Hong-Fei Ye, Xiang Zhang, Zhen-Nan Zhao, Ce Zheng, Ping Fei, Yu Xu, Jiao Lyu, Ji-Li Chen, Xun-Xiang Guo, Huang Zhu, Pei-Quan Zhao   +10 more
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The roles of RNA N6-methyladenosine in esophageal cancer

Heliyon, 2022
Esophageal cancer is a malignant tumour with a high degree of malignancy and high mortality. Its pathogenesis and treatment strategy remain unclear.
Chuan Teng, Fanhua Kong, Jinggang Mo, Weidong Lin, Chong Jin, Kunpeng Wang, Ying Wang   +6 more
doaj   +1 more source

Quantitative Analysis of RNA Modifications [PDF]

, 2010
RNA modifications impact numerous cellular processes such as pre-mRNA splicing and protein synthesis. The elucidation of the mechanisms by which these modifications impact cellular processes necessitates the ability to both detect and quantify the presence of these modifications within RNA molecules.
John, Karijolich, Athena, Kantartzis, Yi-Tao, Yu   +2 more
openaire   +2 more sources

Gene Expression Profile and Prognostic Value of m6A RNA Methylation Regulators in Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma, 2021
Xian Chang,1,* Yang-Fan Lv,2,* Jing He,3,* Ya Cao,2 Chang-Qing Li,1 Qiao-Nan Guo2 1Department of Orthopedics, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, People’s Republic of China; 2Department ...
Chang X, Lv YF, He J, Cao Y, Li CQ, Guo QN   +5 more
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Integrative bulk and single-cell transcriptome analyses reveal RNA modification–related biomarkers of spinal cord injury

Neural Regeneration Research
Aberrant RNA modification has been linked to the pathogenesis of various diseases; however, its specific molecular mechanisms in spinal cord injury remain poorly understood.
Shixue Huang, Kun Jiao, Keqing Li, Jiayan Yuan, Haoming Shu, Yinuo Zhang, Xin Zhou, Xuhui Zhou   +7 more
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Methyltransferase-like 3 Modulates Severe Acute Respiratory Syndrome Coronavirus-2 RNA N6-Methyladenosine Modification and Replication

mBio, 2021
The coronavirus disease 2019 pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an ongoing global public crisis. Although viral RNA modification has been reported based on the transcriptome architecture, the types and ...
Xueyan Zhang, Haojie Hao, Li Ma, Yecheng Zhang, Xiao Hu, Zhen Chen, Di Liu, Jianhui Yuan, Zhangli Hu, Wuxiang Guan   +9 more
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Analysis of eight types of RNA modification regulators and their correlation with the prognosis in hepatocellular carcinoma

Frontiers in Genetics, 2023
RNA modification plays important role in the occurrence and development of hepatocellular carcinoma. The best characterized RNA modification is m6A, while other kinds of RNA modifications have not been fully investigated in hepatocellular carcinoma (HCC).
Wan Qin, Chen Jin, Jun Zou
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