Results 31 to 40 of about 855,003 (301)
Quantitative analysis of snoRNA association with pre-ribosomes and release of snR30 by Rok1 helicase [PDF]
, 2008 In yeast, three small nucleolar RNAs (snoRNAs) are essential for the processing of pre-ribosomal RNA—U3, U14 and snR30—whereas 72 non-essential snoRNAs direct site-specific modification of pre-rRNA. We applied a quantitative screen for alterations in the
Bohnsack, Markus +2 more
core +2 more sources
ALKBHs-facilitated RNA modifications and de-modifications [PDF]
DNA Repair, 2016 The AlkB gene that protects E.coli against methylation damage to DNA was identified more than 3 decades ago. 20 years later, the AlkB protein was shown to catalyze repair of methylated DNA base lesions by oxidative demethylation. Two human AlkB homologs were characterized with similar DNA repair activities and seven additional human AlkB homologs were ...
Endalkachew, A Alemu +2 more
openaire +2 more sources
Instrumental analysis of RNA modifications [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2021 Organisms from all domains of life invest a substantial amount of energy for the introduction of RNA modifications into nearly all transcripts studied to date. Instrumental analysis of RNA can focus on the modified residues and reveal the function of these epitranscriptomic marks.
Yasemin Yoluç +9 more
openaire +3 more sources
Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA [PDF]
, 2012 Ribosomal RNA undergoes various modifications to optimize ribosomal structure and expand the topological potential of RNA. The most common nucleotide modifications in ribosomal RNA (rRNA) are pseudouridylations and 2'-O methylations (Nm), performed by H ...
Entian, Karl-Dieter +5 more
core +1 more source
Detection technologies for RNA modifications
Experimental & Molecular Medicine, 2022 AbstractTo date, more than 170 chemical modifications have been characterized in RNA, providing a new layer of gene expression regulation termed the ‘epitranscriptome’. RNA modification detection methods and tools advance the functional studies of the epitranscriptome.
Zhang, Yan, Lu, Liang, Li, Xiaoyu
openaire +2 more sources
RNA modifications in brain tumorigenesis [PDF]
Acta Neuropathologica Communications, 2020 AbstractRNA modifications are emerging as critical regulators in cancer biology, thanks to their ability to influence gene expression and the predominant protein isoforms expressed during cell proliferation, migration, and other pro-oncogenic properties.
Albert Z. Huang +2 more
openaire +3 more sources
Broad application of a simple and affordable protocol for isolating plant RNA [PDF]
, 2015 BACKGROUND: Standard molecular biological methods involve the analysis of gene expression in living organisms under diverse environmental and developmental conditions. One of the most direct approaches to quantify gene expression is the isolation of RNA.
Ana Arruabarrena +8 more
core +1 more source
Frontiers in Oncology, 2022 N6-methyladenosinen (m6A) methylation is a frequent RNA methylation modification that is regulated by three proteins: “writers”, “erasers”, and “readers”. The m6A modification regulates RNA stability and other mechanisms, including translation, cleavage,
Gaofeng Li +7 more
doaj +1 more source
Broad role for YBX1 in defining the small noncoding RNA composition of exosomes. [PDF]
, 2017 RNA is secreted from cells enclosed within extracellular vesicles (EVs). Defining the RNA composition of EVs is challenging due to their coisolation with contaminants, lack of knowledge of the mechanisms of RNA sorting into EVs, and limitations of ...
Lambowitz, Alan M +6 more
core +1 more source
The roles of RNA N6-methyladenosine in esophageal cancer
Heliyon, 2022 Esophageal cancer is a malignant tumour with a high degree of malignancy and high mortality. Its pathogenesis and treatment strategy remain unclear.
Chuan Teng +6 more
doaj +1 more source