Results 31 to 40 of about 569,878 (258)

It’s the Little Things (in Viral RNA)

mBio, 2020
Chemical modifications of viral RNA are an integral part of the viral life cycle and are present in most classes of viruses. To date, more than 170 RNA modifications have been discovered in all types of cellular RNA.
Jiří František Potužník, Hana Cahová   +1 more
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RNA modification-mediated translational control in immune cells

RNA Biology, 2023
RNA modifications play a vital role in multiple pathways of mRNA metabolism, and translational regulation is essential for immune cells to promptly respond to stimuli and adapt to the microenvironment.
Yujuan Zhang, Weiguo Hu, Hua-Bing Li
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RNA modification of an RNA modifier prevents self-RNA sensing.

PLoS Biology, 2021
A new study in PLOS Biology finds that interferon (IFN)-induced adenosine deaminase acting on RNA 1 (ADAR1) mRNA is N6-methyladenosine (m6A) modified to promote its translation, enabling ADAR1 to modify self-double-stranded RNAs (dsRNAs) generated during
Daltry L Snider, Stacy M Horner
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RNA modifications in brain tumorigenesis [PDF]

Acta Neuropathologica Communications, 2020
AbstractRNA modifications are emerging as critical regulators in cancer biology, thanks to their ability to influence gene expression and the predominant protein isoforms expressed during cell proliferation, migration, and other pro-oncogenic properties.
Albert Z. Huang, Alberto Delaidelli, Poul H. Sorensen   +2 more
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RNA Modifications Meet Tumors

Cancer Management and Research, 2022
Zhiyuan Yang,1,2,* Siyu Zhang,1,2,* Tian Xia,1,2,* Yue Fan,1,2 Ying Shan,1,2 Kaiwen Zhang,1,2 Jiayan Xiong,1,2 Miao Gu,1,2 Bo You1,2 1Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Medical ...
Yang Z, Zhang S, Xia T, Fan Y, Shan Y, Zhang K, Xiong J, Gu M, You B   +8 more
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Comprehensive identification of diverse ribosomal RNA modifications by targeted nanopore direct RNA sequencing and JACUSA2

RNA Biology, 2023
Ribosomal RNAs are decorated by numerous post-transcriptional modifications whose exact roles in ribosome biogenesis, function, and human pathophysiology remain largely unknown.
Isabel S. Naarmann-de Vries, Christiane Zorbas, Amina Lemsara, Michael Piechotta, Felix G. M. Ernst, Ludivine Wacheul, Denis L. J. Lafontaine, Christoph Dieterich   +7 more
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The Identification of Two RNA Modification Patterns and Tumor Microenvironment Infiltration Characterization of Lung Adenocarcinoma

Frontiers in Genetics, 2022
Background: RNA modification plays an important role in many diseases. A comprehensive study of tumor microenvironment (TME) characteristics mediated by RNA modification regulators will improve the understanding of TME immune regulation.Methods: We ...
Wan He, Gengpeng Lin, Chaohu Pan, Chaohu Pan, Chaohu Pan, Wenwen Li, Jing Shen, Yangli Liu, Hui Li, Dongfang Wu, Xuejia Lin, Xuejia Lin   +11 more
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Nanoparticle-Induced m⁶A RNA Modification: Detection Methods, Mechanisms and Applications

Nanomaterials, 2022
With the increasing application of nanoparticles (NPs) in medical and consumer applications, it is necessary to ensure their safety. As m6A (N6-methyladenosine) RNA modification is one of the most prevalent RNA modifications involved in many diseases and
Yi Wang, Fengkai Ruan, Zhenghong Zuo, Chengyong He   +3 more
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Instrumental analysis of RNA modifications [PDF]

Critical Reviews in Biochemistry and Molecular Biology, 2021
Organisms from all domains of life invest a substantial amount of energy for the introduction of RNA modifications into nearly all transcripts studied to date. Instrumental analysis of RNA can focus on the modified residues and reveal the function of these epitranscriptomic marks.
Yasemin Yoluç, Gregor Ammann, Pierre Barraud, Manasses Jora, Patrick A. Limbach, Yuri Motorin, Virginie Marchand, Carine Tisné, Kayla Borland, Stefanie Kellner   +9 more
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Cellular Dynamics of RNA Modification [PDF]

Accounts of Chemical Research, 2011
Five decades of research have identified more than 100 ribonucleosides that are post-transcriptionally modified. Many modified nucleosides are conserved throughout bacteria, archaea, and eukaryotes, while some are unique to each branch of life. However, the cellular and functional dynamics of RNA modification remain largely unexplored, mostly because ...
Chengqi, Yi, Tao, Pan
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