Results 21 to 30 of about 855,003 (301)

The Identification of Two RNA Modification Patterns and Tumor Microenvironment Infiltration Characterization of Lung Adenocarcinoma

Frontiers in Genetics, 2022
Background: RNA modification plays an important role in many diseases. A comprehensive study of tumor microenvironment (TME) characteristics mediated by RNA modification regulators will improve the understanding of TME immune regulation.Methods: We ...
Wan He, Gengpeng Lin, Chaohu Pan, Chaohu Pan, Chaohu Pan, Wenwen Li, Jing Shen, Yangli Liu, Hui Li, Dongfang Wu, Xuejia Lin, Xuejia Lin   +11 more
doaj   +1 more source

Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method. [PDF]

, 2016
Adenosine deamination is one of the most prevalent post-transcriptional modifications in mRNA. In humans, ADAR1 and ADAR2 catalyze this modification and their malfunction correlates with disease. Recently our laboratory reported crystal structures of the
Beal, Peter A, Wang, Yuru
core   +1 more source

Functional organization of box C/D RNA-guided RNA methyltransferase [PDF]

, 2020
Box C/D RNA protein complexes (RNPs) catalyze site-specific 2'-O-methylation of RNA with specificity determined by guide RNAs. In eukaryotic C/D RNP, the paralogous Nop58 and Nop56 proteins specifically associate with terminal C/D and internal C'/D ...
Huang, Lin, Lilley, David M. J., Wang, Jiayin, Yang, Zuxiao, Ye, Keqiong   +4 more
core   +2 more sources

The epitranscriptomic writer ALKBH8 drives tolerance and protects mouse lungs from the environmental pollutant naphthalene

Epigenetics, 2020
The epitranscriptomic writer Alkylation Repair Homolog 8 (ALKBH8) is a transfer RNA (tRNA) methyltransferase that modifies the wobble uridine of selenocysteine tRNA to promote the specialized translation of selenoproteins.
Andrea Leonardi, Nataliia Kovalchuk, Lei Yin, Lauren Endres, Sara Evke, Steven Nevins, Samuel Martin, Peter C. Dedon, J. Andres Melendez, Laura Van Winkle, Qing-Yu Zhang, Xinxin Ding, Thomas J. Begley   +12 more
doaj   +1 more source

RNA modification-mediated translational control in immune cells

RNA Biology, 2023
RNA modifications play a vital role in multiple pathways of mRNA metabolism, and translational regulation is essential for immune cells to promptly respond to stimuli and adapt to the microenvironment.
Yujuan Zhang, Weiguo Hu, Hua-Bing Li
doaj   +1 more source

Nanoparticle-Induced m⁶A RNA Modification: Detection Methods, Mechanisms and Applications

Nanomaterials, 2022
With the increasing application of nanoparticles (NPs) in medical and consumer applications, it is necessary to ensure their safety. As m6A (N6-methyladenosine) RNA modification is one of the most prevalent RNA modifications involved in many diseases and
Yi Wang, Fengkai Ruan, Zhenghong Zuo, Chengyong He   +3 more
doaj   +1 more source

Non-CG methylation patterns shape the epigenetic landscape in Arabidopsis. [PDF]

, 2013
DNA methylation occurs in CG and non-CG sequence contexts. Non-CG methylation is abundant in plants and is mediated by CHROMOMETHYLASE (CMT) and DOMAINS REARRANGED METHYLTRANSFERASE (DRM) proteins; however, its roles remain poorly understood.
Do, Truman, Du, Jiamu, Feng, Suhua, Jacobsen, Steven E, Johnson, Lianna, Patel, Dinshaw J, Stroud, Hume, Zhong, Xuehua   +7 more
core   +5 more sources

Comprehensive identification of diverse ribosomal RNA modifications by targeted nanopore direct RNA sequencing and JACUSA2

RNA Biology, 2023
Ribosomal RNAs are decorated by numerous post-transcriptional modifications whose exact roles in ribosome biogenesis, function, and human pathophysiology remain largely unknown.
Isabel S. Naarmann-de Vries, Christiane Zorbas, Amina Lemsara, Michael Piechotta, Felix G. M. Ernst, Ludivine Wacheul, Denis L. J. Lafontaine, Christoph Dieterich   +7 more
doaj   +1 more source

Lithium alters expression of RNAs in a type-specific manner in differentiated human neuroblastoma neuronal cultures, including specific genes involved in Alzheimer's disease. [PDF]

, 2019
Lithium (Li) is a medication long-used to treat bipolar disorder. It is currently under investigation for multiple nervous system disorders, including Alzheimer's disease (AD).
Balaraman, Yokesh, Chopra, Nipun, Edenberg, Howard J, Kelsoe, John, Lahiri, Debomoy K, Liu, Yunlong, Maloney, Bryan, Nurnberger, John I   +7 more
core   +3 more sources

microRNA-mediated differential expression of TRMU, GTPBP3 and MTO1 in cell models of mitochondrial-DNA diseases

Scientific Reports, 2017
Mitochondrial diseases due to mutations in the mitochondrial (mt) DNA are heterogeneous in clinical manifestations but usually include OXPHOS dysfunction. Mechanisms by which OXPHOS dysfunction contributes to the disease phenotype invoke, apart from cell
Salvador Meseguer, Olga Boix, Carmen Navarro-González, Magda Villarroya, Rachid Boutoual, Sonia Emperador, Elena García-Arumí, Julio Montoya, M.-Eugenia Armengod   +8 more
doaj   +1 more source