Results 11 to 20 of about 564,596 (305)
RNA modifications and cancer [PDF]
RNA Biology, 2020 RNA plays essential roles in not only translating nucleic acids into proteins, but also in gene regulation, environmental interactions and many human diseases. Nature uses over 150 chemical modifications to decorate RNA and diversify its functions. With the fast-growing RNA research in the burgeoning field of 'epitranscriptome', a term describes post ...
Phensinee Haruehanroengra +4 more
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Novel Modifications in RNA [PDF]
ACS Chemical Biology, 2011 The past several years have seen numerous reports of new chemical modifications for use in RNA. In addition, in that time period, we have seen the discovery of several previously unknown naturally occurring modifications that impart novel properties on the parent RNAs.
Kelly, Phelps +2 more
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RNA Biology, 2022 The universal dihydrouridine (D) epitranscriptomic mark results from a reduction of uridine by the Dus family of NADPH-dependent reductases and is typically found within the eponym D-loop of tRNAs.
Olivier Finet +3 more
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The RNA modification database [PDF]
Nucleic Acids Research, 1996 The RNA modification database provides a comprehensive listing of posttranscriptionally modified nucleosides from all RNAs, and is maintained as an updated version of the initial printed report [Limbach,P.A., Crain,P.F. and McCloskey,J.A. (1994)Nucleic Acids Res. , 22, 2183-2196].
Pamela F. Crain, James A. McCloskey
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RNA Phosphorothioate Modification in Prokaryotes and Eukaryotes
, 2020 We report the first RNA phosphorothioate modification in both prokaryotes and eukaryotes. The GpsG modification exists in the Rp configuration and was quantified with liquid chromatography coupled with tandem mass spectrometry.
Ying, Wu +7 more
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Detection of RNA modifications [PDF]
RNA Biology, 2010 RNA nucleotide modifications are typically of low abundance and frequently go unnoticed by standard detection methods of molecular biology and cell biology. With a burst of knowledge intruding from such diverse areas as genomics, structural biology, regulation of gene expression and immunology, it becomes increasingly clear that many exciting functions
Stefanie, Kellner +2 more
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Sabiad, 2023 Objective: Post-transcriptional modifications like m6A (N6-methyladenosine) and secondary structures like G-quadruplex (G4) are formations that play a vital role in RNA processing. Their synergy also has functional consequences.
Çağrı Güleç
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Instrumental analysis of RNA modifications [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2021 Organisms from all domains of life invest a substantial amount of energy for the introduction of RNA modifications into nearly all transcripts studied to date. Instrumental analysis of RNA can focus on the modified residues and reveal the function of these epitranscriptomic marks.
Yasemin Yoluç +9 more
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No evidence for age-related differences in mitochondrial RNA quality in the female germline
Reproduction and Fertility, 2022 Mitochondrial quality is implicated as a contributor to declining fertility with aging. We investigated mitochondrial transcripts in oocytes and their associated cumulus cells from mice of different ages using RNA-seq.
Fiona Hartley +7 more
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Role of m6A in Embryonic Stem Cell Differentiation and in Gametogenesis
Epigenomes, 2020 The rising field of RNA modifications is stimulating massive research nowadays. m6A, the most abundant mRNA modification is highly conserved during evolution.
Lior Lasman +2 more
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