Results 61 to 70 of about 564,596 (305)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Research Progress on Epigenetic Regulation of Fungal Secondary Metabolism

Guangdong nongye kexue
Fungi are capable of synthesizing a wide array of secondary metabolites with diverse structures and biological activities, which have significant applications in agriculture, medicine, food, and industry.
Siyi TAN, Guanxian CHEN, Lei HE, Qingqing ZHI   +3 more
doaj   +1 more source

RNA modifications in mammals: from basic research to biotechnological application [PDF]

ExRNA
RNA, a crucial molecule in protein synthesis and gene expression regulation, plays an essential role in organisms. RNA modifications, acting as epigenetic marks, subtly adjust the structure, stability, and function of RNA, thereby regulating gene ...
Yihang Li, Yongle Liu, Hongyuan Guo, Zheng Fu   +3 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

RNA 5-Methylcytosine Modification in Myocardial Fibrosis

Reviews in Cardiovascular Medicine
Myocardial fibrosis represents a common pathological hallmark of various cardiovascular diseases progressing to heart failure, with the immunoinflammatory response playing a pivotal role in the pathogenesis of myocardial fibrosis.
Bohan Li, Yan Hao, Wendan Tian, Wei Liu
doaj   +1 more source

Molecular Characterization of m6A Modifications in Non-Clear Cell Renal Cell Carcinoma and Potential Relationship with Pathological Types

International Journal of General Medicine, 2022
Xuebao Xiang, Yi Guo, Zhongyuan Chen, Zengnan Mo Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical ...
Xiang X, Guo Y, Chen Z, Mo Z
doaj  

RNA modifications in insects

Frontiers in Insect Science
More than 100 RNA chemical modifications to cellular RNA have been identified. N6-methyladenosine (m6A) is the most prevalent modification of mRNA. RNA modifications have recently attracted significant attention due to their critical role in regulating mRNA processing and metabolism.
Yaoyu Jiao, Yaoyu Jiao, Subba Reddy Palli   +2 more
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The Role of m6A Ribonucleic Acid Modification in the Occurrence of Atherosclerosis

Frontiers in Genetics, 2021
The N6-methyladenosine (m6A) modification is the most abundant epitranscriptomic modification in eukaryotic messenger RNA (mRNA). The m6A modification process is jointly regulated by various enzymes and proteins, such as methyltransferases, demethylases ...
Jie Fu, Jie Fu, Xinghui Cui, Xinghui Cui, Xiaoyun Zhang, Min Cheng, Xiaoxia Li, Zhiliang Guo, Xiaodong Cui   +8 more
doaj   +1 more source

Nucleobase modification by an RNA enzyme [PDF]

Nucleic Acids Research, 2016
Ribozymes can catalyze phosphoryl or nucleotidyl transfer onto ribose hydroxyls of RNA chains. We report a single ribozyme that performs both reactions, with a nucleobase serving as initial acceptor moiety. This unprecedented combined reaction was revealed while investigating potential contributions of ribose hydroxyls to catalysis by kinase ribozyme ...
Poudyal, Raghav R., Nguyen, Phuong D. M., Lokugamage, Melissa P., Callaway, Mackenzie K., Gavette, Jesse V., Krishnamurthy, Ramanarayanan, Burke, Donald H.   +6 more
openaire   +2 more sources