Results 1 to 10 of about 89,806 (111)

Nuclear mRNA export [PDF]

Acta Biochimica et Biophysica Sinica
In eukaryotic cells, gene expression begins with transcription in the nucleus, followed by the maturation of messenger RNAs (mRNAs). These mRNA molecules are then exported to the cytoplasm through the nuclear pore ...
Chen Suli, Jiang Qingyi, Fan Jing, Cheng Hong   +3 more
doaj   +2 more sources

The deubiquitylase Ubp15 couples transcription to mRNA export [PDF]

eLife, 2020
Nuclear export of messenger RNAs (mRNAs) is intimately coupled to their synthesis. pre-mRNAs assemble into dynamic ribonucleoparticles as they are being transcribed, processed, and exported.
Fanny Eyboulet, Célia Jeronimo, Jacques Côté, François Robert   +3 more
doaj   +2 more sources

The FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export [PDF]

Cell Reports
Summary: Fanconi anemia (FA) is characterized by congenital abnormalities, bone marrow failure, and cancer susceptibility. The central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for ...
Anne Olazabal-Herrero, Boxue He, Youngho Kwon, Abhishek K. Gupta, Arijit Dutta, Yuxin Huang, Prajwal Boddu, Zhuobin Liang, Fengshan Liang, Yaqun Teng, Li Lan, Xiaoyong Chen, Huadong Pei, Manoj M. Pillai, Patrick Sung, Gary M. Kupfer   +15 more
doaj   +2 more sources

Molecular insights into mRNA export regulation by the human TREX-2 complex [PDF]

Nature Communications
The nuclear export of mRNA represents a critical regulatory node in eukaryotic gene expression. This process is orchestrated by two conserved multi-subunit assemblies: the transcription-and-export complex (TREX) and TREX-2.
Xing Gong, Ran Tao, Xiaofei Ge, Huihui Zhu, Mengqi Li, Yufang Chen, Yongxiang Gao, Jing Hang, Xiaofeng Zhang   +8 more
doaj   +2 more sources

SUN5, a testis-specific nuclear membrane protein, participates in recruitment and export of nuclear mRNA in spermatogenesis [PDF]

Acta Biochimica et Biophysica Sinica
SUN5, a testis-specific gene, is associated with acephalic spermatozoa syndrome (ASS). Here, we demonstrate that SUN5 is involved in mRNA export. In Sun5-knockout mice (Sun5–/–), poly(A)+ RNA accumulates in the nuclei of germ cells, leading to reduced ...
He Xiyi, Zhang Yunfei, Mao Zenghui, Liu Gang, Huang Lihua, Liu Xiaowen, Su Yuyan, Xing Xiaowei   +7 more
doaj   +2 more sources

Nuclear Imprisonment: Viral Strategies to Arrest Host mRNA Nuclear Export

Viruses, 2013
Viruses possess many strategies to impair host cellular responses to infection. Nuclear export of host messenger RNAs (mRNA) that encode antiviral factors is critical for antiviral protein production and control of viral infections.
Beatriz M. A. Fontoura, Liang Zhang, Miguel A. Mata, Sharon K. Kuss   +3 more
doaj   +3 more sources

The mRNA Export Receptor NXF1 Coordinates Transcriptional Dynamics, Alternative Polyadenylation, and mRNA Export [PDF]

Molecular Cell, 2019
Bin Tian, Hong Cheng, Ruijia Wang
exaly   +2 more sources

Cellular hnRNPAB binding to viral nucleoprotein inhibits flu virus replication by blocking nuclear export of viral mRNA

iScience, 2021
Summary: Heterogeneous nuclear ribonucleoproteins (hnRNPs) play critical roles in the nuclear export, splicing, and sensing of RNA. However, the role of heterogeneous nuclear ribonucleoprotein A/B (hnRNPAB) is poorly understood.
Xingbo Wang, Lulu Lin, Yiye Zhong, Mingfang Feng, Tianqi Yu, Yan Yan, Jiyong Zhou, Min Liao   +7 more
doaj   +1 more source

The Ebola Virus Nucleoprotein Recruits the Nuclear RNA Export Factor NXF1 into Inclusion Bodies to Facilitate Viral Protein Expression

Cells, 2020
Ebola virus (EBOV) causes severe outbreaks of viral hemorrhagic fever in humans. While virus-host interactions are promising targets for antivirals, there is only limited knowledge regarding the interactions of EBOV with cellular host factors.
Lisa Wendt, Janine Brandt, Bianca S. Bodmer, Sven Reiche, Marie Luisa Schmidt, Shelby Traeger, Thomas Hoenen   +6 more
doaj   +1 more source

Nuclear Export of Pre-Ribosomal Subunits Requires Dbp5, but Not as an RNA-Helicase as for mRNA Export. [PDF]

PLoS ONE, 2016
The DEAD-box RNA-helicase Dbp5/Rat8 is known for its function in nuclear mRNA export, where it displaces the export receptor Mex67 from the mRNA at the cytoplasmic side of the nuclear pore complex (NPC).
Bettina Neumann, Haijia Wu, Alexandra Hackmann, Heike Krebber   +3 more
doaj   +1 more source