RBM15 affects mitophagy in intracerebral hemorrhage by promoting E2F1 nuclear translocation via NXF1 [PDF]
Frontiers in ImmunologyNuclear mRNA transport is essential for maintaining mRNA homeostasis and normal cellular functions; however, the mechanisms regulating the nuclear transport of E2F transcription factor 1 (E2F1) mRNA remain poorly understood.
Jiwei Sun +7 more
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Novel nuclear RNA export factor 1 adaptor drives tumor growth by increasing proliferation-stimulatory mRNA export [PDF]
Signal Transduction and Targeted TherapymRNA nuclear export is an essential biological process that is mediated primarily by nuclear export factor 1 (NXF1). NXF1 exerts its mRNA transport activity by binding to adaptor proteins.
Jin-Yu Liu +9 more
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Cells, 2020 Ebola virus (EBOV) causes severe outbreaks of viral hemorrhagic fever in humans. While virus-host interactions are promising targets for antivirals, there is only limited knowledge regarding the interactions of EBOV with cellular host factors.
Sven Reiche, Bianca S Bodmer, Lisa Wendt
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NXF1 suppresses progression of endometrial cancer by interacting with the SRSF3 to regulate SP4 splicing [PDF]
iScienceSummary: Conventional treatments for advanced endometriosis often have limited efficacy due to chemotherapy resistance, recurrence, and metastasis.
Nan Meng +11 more
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Nuclear Export of Human Hepatitis B Virus Core Protein and Pregenomic RNA Depends on the Cellular NXF1-p15 Machinery [PDF]
PLoS ONE, 2014 Hepatitis B virus (HBV) core protein (HBc) can shuttle between nucleus and cytoplasm. Cytoplasm-predominant HBc is clinically associated with severe liver inflammation.
Chiaho Shih, Pei-Yi
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Mixed Messages: Dynamic and Compositional Heterogeneity of Nuclear Messenger Ribonucleoprotein (mRNP) Complexes. [PDF]
Wiley Interdiscip Rev RNARNA‐protein (RNP) complexes formed by a network of RNA–RNA, RNA–protein, and protein–protein interactions are central to gene expression. mRNP compositional heterogeneity underlies precise regulation (e.g., export, storage, translation, and decay), enabling cells to adapt to changing conditions, with changes in composition further linked to stress ...
Wechsler T, Asada R, Montpetit B.
europepmc +2 more sources
A new mechanism underlying mitochondrial dysfunction in schizophrenia – attenuated mRNA transport of the complex I subunit NDUFV2 by its pseudogene NDUFV2P1 [PDF]
SchizophreniaWhile schizophrenia (SZ) etiology remains unclear, accumulating evidence implicates mitochondrial dysfunction, particularly complex-I of the respiratory chain and its essential free-electron scavenger subunit, NDUFV2, as a contributor to neuronal and ...
Rachel Karry, Dorit Ben-Shachar
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NXT2 is a key component of the RNA nuclear export factor complex in the human testis and essential for spermatogenesis [PDF]
Nature CommunicationsIn eukaryotes, the nucleocytoplasmic export of bulk poly(A)+-mRNAs through the nuclear pore complex is mediated by the ubiquitously expressed NXT1-NXF1 heterodimer.
Ann-Kristin Dicke +14 more
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Identifying a broad-spectrum influenza inhibitor that blocks multiple functions of viral NS1 protein [PDF]
Nature CommunicationsNonstructural protein 1 (NS1) is the key virulence factor of influenza A virus (IAV) that affects the replication and pathogenicity of IAV, which can be used as a promising anti-IAV target.
Yang Zhang +9 more
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HSV ICP27 hijacks host splicing factor SRSF3 to regulate pre-mRNA splicing and export for viral gene expression and immune evasion. [PDF]
PLoS PathogensHSV ICP27, a multifunctional essential immediate early (IE) viral protein, regulates both viral and host pre-mRNA processing in a gene/sequence-specific manner.
Shuang Tang +4 more
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