Results 41 to 50 of about 2,530 (193)
CRM1-spike-mediated nuclear export of hepatitis B virus encapsidated viral RNA
Cell Reports, 2022 Summary: Hepatitis B virus (HBV) is a global pathogen. We report here that the cellular CRM1 machinery can mediate nuclear export of entire HBV core (HBc) particles containing encapsidated viral RNAs.
Ching-Chun Yang +10 more
doaj +1 more source
Strength in Diversity: Nuclear Export of Viral RNAs
Viruses, 2020 The nuclear export of cellular mRNAs is a complex process that requires the orchestrated participation of many proteins that are recruited during the early steps of mRNA synthesis and processing.
Jón Pol Gales +3 more
doaj +1 more source
WRN modulates translation by influencing nuclear mRNA export in HeLa cancer cells
BMC Molecular and Cell Biology, 2020 Background The Werner syndrome protein (WRN) belongs to the RecQ family of helicases and its loss of function results in the premature aging disease Werner syndrome (WS).
Juan Manuel Iglesias-Pedraz +5 more
doaj +1 more source
Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases [PDF]
Human Molecular Genetics, 2011 Expanded CAG RNA has recently been reported to contribute to neurotoxicity in polyglutamine (polyQ) degeneration. In this study, we showed that RNA carrying an expanded CAG repeat progressively accumulated in the cell nucleus of transgenic Drosophila that displayed degeneration.
Ho, Tsoi +3 more
openaire +2 more sources
Murine Leukemia Virus Uses NXF1 for Nuclear Export of Spliced and Unspliced Viral Transcripts [PDF]
Journal of Virology, 2014 ABSTRACT Intron-containing mRNAs are subject to restricted nuclear export in higher eukaryotes. Retroviral replication requires the nucleocytoplasmic transport of both spliced and unspliced RNA transcripts, and RNA export mechanisms of gammaretroviruses are poorly characterized.
Toshie, Sakuma +5 more
openaire +2 more sources
Viruses, 2014 Previously we reported that nuclear export of both unspliced and spliced murine leukemia virus (MLV) transcripts depends on the nuclear export factor (NXF1) pathway.
Toshie Sakuma +2 more
doaj +1 more source
Nucleoporin TPR promotes tRNA nuclear export and protein synthesis in lung cancer cells.
PLoS Genetics, 2021 The robust proliferation of cancer cells requires vastly elevated levels of protein synthesis, which relies on a steady supply of aminoacylated tRNAs. Delivery of tRNAs to the cytoplasm is a highly regulated process, but the machinery for tRNA nuclear ...
Miao Chen +8 more
doaj +1 more source
Topological relationship between Chtop and Nxf1 analysed by FLIM-FRET.
, 2013 (A) HeLa cells were transfected with both donor Chtop-ECFP and indicated acceptors Nxf1-EYFP, Nxf1C-terminus-EYFP and EYFP. Bar graph of FRET efficiency was analyzed by FLIM-FRET.
I-Fang Teng (425555) +1 more
core +1 more source
Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction
PROTEOMICS, Volume 26, Issue 8, Page 9-28, August 2026.ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella +6 more
wiley +1 more source
Annals of the New York Academy of Sciences, Volume 1561, Issue 1, July 2026.Ataxin‐1 has been recently implicated in B cell regulation in the context of multiple sclerosis pathology. In this study, we used a multiomics pipeline to profile the B cell transcriptome, epigenome, and proteome in response to encephalitogenic challenges.
Jonathan J. Carver +6 more
wiley +1 more source