Results 51 to 60 of about 2,530 (193)
SUN1, a component of the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex, functions in mammalian mRNA export through the NXF1-dependent pathway. It associates with mRNP complexes by direct interaction with NXF1.
Ping Li +5 more
doaj +1 more source
Retroviruses encode cis-acting RNA nuclear export elements that override nuclear retention of intron-containing viral mRNAs including the full-length, unspliced genomic RNAs (gRNAs) packaged into assembling virions.
Ginger M Pocock +4 more
doaj +1 more source
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang +10 more
wiley +1 more source
TREX complex associates with Nxf1 in the vicinity of nuclear speckles.
(A and B) 293T cells transiently expressing Chtop-GFP, Nxf1-GFP, GFP or mock transfected were immunoprecipitated with anti-GFP antibody and detected by Western blot with the indicated antibodies.
I-Fang Teng (425555) +1 more
core +1 more source
The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective
N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu +8 more
wiley +1 more source
Analysis of the Nxf1:Alyref interaction in living HeLa cells.
(A) Quantitative analysis of NFRET values for different pairs of donor and acceptor in live HeLa cells by sensitized emission FRET (mean ± SD for n = 22–32 cells ...
I-Fang Teng (425555) +1 more
core +1 more source
Circular RNAs: Epigenetic Puppeteers Pulling the Strings of Cancer Pathogenesis
ABSTRACT Circular RNAs (circRNAs), a unique class of endogenous noncoding RNAs characterized by their covalently closed loop structure, have emerged as pivotal players in cancer biology due to their exceptional stability, tissue‐specific expression, and diverse regulatory functions.
Yimao Wu +4 more
wiley +1 more source
This is the processed SLAM-seq data from Zuckerman et al., Mol Cell 2020 (https://doi.org/10.1016/j.molcel.2020.05.013). The zip file contains the full output from the processing pipeline (including the mapped reads, the scripts to run the pipeline and ...
Erhard
core +1 more source
Structure of the human core transcription-export complex reveals a hub for multivalent interactions
The export of mRNA from nucleus to cytoplasm requires the conserved and essential transcription and export (TREX) complex (THO–UAP56/DDX39B–ALYREF). TREX selectively binds mRNA maturation marks and licenses mRNA for nuclear export by loading the export ...
Thomas Pühringer +6 more
doaj +1 more source
Background Understanding gene transcription and mRNA-protein (mRNP) dynamics in single cells in a multicellular organism has been challenging. The catalytically dead CRISPR-Cas13 (dCas13) system has been used to visualize RNAs in live cells without ...
Youkui Huang +9 more
doaj +1 more source

