Results 51 to 60 of about 2,530 (193)

The function of the inner nuclear envelope protein SUN1 in mRNA export is regulated by phosphorylation

open access: yesScientific Reports, 2017
SUN1, a component of the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex, functions in mammalian mRNA export through the NXF1-dependent pathway. It associates with mRNP complexes by direct interaction with NXF1.
Ping Li   +5 more
doaj   +1 more source

HIV-1 and M-PMV RNA Nuclear Export Elements Program Viral Genomes for Distinct Cytoplasmic Trafficking Behaviors.

open access: yesPLoS Pathogens, 2016
Retroviruses encode cis-acting RNA nuclear export elements that override nuclear retention of intron-containing viral mRNAs including the full-length, unspliced genomic RNAs (gRNAs) packaged into assembling virions.
Ginger M Pocock   +4 more
doaj   +1 more source

Small Nucleolar RNA Snord17 Promotes Self‐Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation

open access: yesAdvanced Science, Volume 13, Issue 13, 3 March 2026.
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang   +10 more
wiley   +1 more source

TREX complex associates with Nxf1 in the vicinity of nuclear speckles.

open access: yes, 2013
(A and B) 293T cells transiently expressing Chtop-GFP, Nxf1-GFP, GFP or mock transfected were immunoprecipitated with anti-GFP antibody and detected by Western blot with the indicated antibodies.
I-Fang Teng (425555)   +1 more
core   +1 more source

The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective

open access: yesImmunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu   +8 more
wiley   +1 more source

Analysis of the Nxf1:Alyref interaction in living HeLa cells.

open access: yes, 2013
(A) Quantitative analysis of NFRET values for different pairs of donor and acceptor in live HeLa cells by sensitized emission FRET (mean ± SD for n = 22–32 cells ...
I-Fang Teng (425555)   +1 more
core   +1 more source

Circular RNAs: Epigenetic Puppeteers Pulling the Strings of Cancer Pathogenesis

open access: yesMedicine Bulletin, Volume 2, Issue 1, Page 124-136, January 2026.
ABSTRACT Circular RNAs (circRNAs), a unique class of endogenous noncoding RNAs characterized by their covalently closed loop structure, have emerged as pivotal players in cancer biology due to their exceptional stability, tissue‐specific expression, and diverse regulatory functions.
Yimao Wu   +4 more
wiley   +1 more source

GRAND-SLAM analysis of NXF1 knockout cells from Zuckerman et al., Mol Cell 2020 (https://doi.org/10.1016/j.molcel.2020.05.013)

open access: yes, 2022
This is the processed SLAM-seq data from Zuckerman et al., Mol Cell 2020 (https://doi.org/10.1016/j.molcel.2020.05.013). The zip file contains the full output from the processing pipeline (including the mapped reads, the scripts to run the pipeline and ...
Erhard
core   +1 more source

Structure of the human core transcription-export complex reveals a hub for multivalent interactions

open access: yeseLife, 2020
The export of mRNA from nucleus to cytoplasm requires the conserved and essential transcription and export (TREX) complex (THO–UAP56/DDX39B–ALYREF). TREX selectively binds mRNA maturation marks and licenses mRNA for nuclear export by loading the export ...
Thomas Pühringer   +6 more
doaj   +1 more source

CRISPR-dCas13-tracing reveals transcriptional memory and limited mRNA export in developing zebrafish embryos

open access: yesGenome Biology, 2023
Background Understanding gene transcription and mRNA-protein (mRNP) dynamics in single cells in a multicellular organism has been challenging. The catalytically dead CRISPR-Cas13 (dCas13) system has been used to visualize RNAs in live cells without ...
Youkui Huang   +9 more
doaj   +1 more source

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