Results 71 to 80 of about 2,530 (193)
Clinical and Translational Medicine, Volume 15, Issue 2, February 2025.An overview of the paclitaxel resistance mechanism induced by RNF31‐mediated ALYREF subcellular distribution. RNF31 promoted the linear ubiquitination of ALYREF, subsequently enhancing ALYREF nuclear transport via IPO13 upon PTX treatment. In addition, RNF31‐mediated ubiquitination of ALYREF facilitated ALYREF binding and export of PTX resistance ...
Shumei Huang +17 more
wiley +1 more source
Knockdown of TAP/NXF1 alters expression of some VZV proteins.
, 2013 HEK293 cells were not transfected (lanes 1 and 4) or transfected with the negative siRNA pool (lanes 2 and 5) or the TAP/NXF1 siRNA pool (lanes 3 and 6) for 24 h followed by mock- (lanes 1 to 3) or VZV-infection for 36 h (lanes 4 to 6). Expression of the
Cahora Medina-Palazon (369300) +7 more
core +1 more source
MedComm, Volume 6, Issue 2, February 2025.Circular RNAs (circRNAs) play essential roles in hallmarks of cancer, exerting either oncogenic or tumor‐suppressive effects, as observed in thyroid cancer. This review presents an extensive review of circRNAs, encompassing their biogenesis, characteristics, functions, and mechanisms of turnover.
Yang Guo +8 more
wiley +1 more source
YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs
eLife, 2017 N6-methyladenosine (m6A) is the most abundant internal modification of eukaryotic messenger RNA (mRNA) and plays critical roles in RNA biology. The function of this modification is mediated by m6A-selective ‘reader’ proteins of the YTH family, which ...
Ian A Roundtree +12 more
doaj +1 more source
mLife, Volume 4, Issue 1, Page 55-69, February 2025.Abstract The global dissemination of H5 avian influenza viruses represents a significant threat to both human and animal health. In this study, we conducted a genome‐wide siRNA library screening against the highly pathogenic H5N1 influenza virus, leading us to the identification of 457 cellular cofactors (441 proviral factors and 16 antiviral factors ...
Guangwen Wang +15 more
wiley +1 more source
The spatial interactions of Nxf1 and Alyref in single cells by FLIM-FRET.
, 2013 (A) Bar graph of FLIM-FRET efficiency of donor Alyref-ECFP with acceptor Nxf1-EYFP or EYFP (mean ± SD for n = 18–27 cells ...
I-Fang Teng (425555) +1 more
core +1 more source
eLife, 2018 The establishment and maintenance of pluripotency depend on precise coordination of gene expression. We establish serine-arginine-rich splicing factor 3 (SRSF3) as an essential regulator of RNAs encoding key components of the mouse pluripotency circuitry,
Madara Ratnadiwakara +8 more
doaj +1 more source
Localization of nucleoporin Tpr to the nuclear pore complex is essential for Tpr mediated regulation of the export of unspliced RNA. [PDF]
PLoS ONE, 2012 Nucleoporin Tpr is a component of the nuclear pore complex (NPC) that localizes exclusively to intranuclear filaments. Tpr functions as a scaffolding element in the nuclear phase of the NPC and plays a role in mitotic spindle checkpoint signalling ...
Kalpana Rajanala, Vinay Kumar Nandicoori
doaj +1 more source
Transcription Kinetics in the Coronavirus Life Cycle
WIREs RNA, Volume 16, Issue 1, January/February 2025.The steps involved in a Coronavirus infection are interconnected and exhibit complex kinetics, with some processes depending on each other, while others occur independently. Understanding the basic kinetics of major processes like translation, transcription, and virion assembly in the Coronavirus life cycle adds temporal resolution to the classical ...
Katarzyna Grelewska‐Nowotko +2 more
wiley +1 more source
IE4 interacts with TAP/NXF1 and Aly/REF.
, 2013 (A) In vitro binding assays were performed by incubating GST-TAP (lanes 2 to 7) or GST-REF (lanes 9 to 14) with in vitro-translated IE4-V5 or derivatives as indicated. Assays performed with GST alone constituted the negative control (−) (lanes 1 and 8). (
Cahora Medina-Palazon (369300) +7 more
core +1 more source