Results 81 to 90 of about 2,530 (193)
The RNA-binding Motif Protein 15B (RBM15B/OTT3) Acts as Cofactor of the Nuclear Export Receptor NXF1 [PDF]
Journal of Biological Chemistry, 2009 The human SPEN family proteins SHARP, RBM15/OTT1, and RBM15B/OTT3 share the structural domain architecture but show distinct functional properties. Here, we examined the function of OTT3 and compared it with its paralogues RBM15 and SHARP. We found that OTT3, like RBM15, has post-transcriptional regulatory activity, whereas SHARP does not, supporting a
Uranishi, Hiroaki +9 more
openaire +2 more sources
BMC Bioinformatics, 2022 Background Hepatocellular carcinoma (HCC) is a primary malignant tumor that accounts for approximately 90% of all cases of primary liver cancer worldwide.
Gang Chi, Jin-Hong Pei, Xue-Qing Li
doaj +1 more source
Immunity, Inflammation and Disease, Volume 12, Issue 12, December 2024.N6‐methyladenosine (m6A) modification, a prevalent and reversible epigenetic modification in eukaryotic mRNA, has emerged as a crucial regulator in various biological processes. Recent studies have shed light on the significant role of m6A modification in female reproductive development and its related diseases.
Xiangrong Cui +6 more
wiley +1 more source
ACR Open Rheumatology, Volume 6, Issue 11, Page 769-779, November 2024.Objective There is an established yet unexplained link between interferon (IFN) and systemic lupus erythematosus (SLE). The expression of sequences derived from transposable elements (TEs) may contribute to SLE phenotypes, specifically production of type I IFNs and generation of autoantibodies.
Zachary Cutts +12 more
wiley +1 more source
Nuclear accumulation of tRNAs and reduced growth in NXF1 knockdown cells.
, 2021 (A) Nuclear enrichment of tRNAs in H322 (top), H460 (middle) and H1299 (bottom) cells without (control) and with NXF1 knockdown (Nsi-1 and Nsi-2). Relative nuclear enrichment of each tRNA tested was determined by its nuclear / total expression normalized
Qian Long (3417518) +8 more
core +1 more source
RNA modification in normal hematopoiesis and hematologic malignancies
MedComm, Volume 5, Issue 11, November 2024.N6‐methyladenosine (m6A) is the most abundant RNA modification in eukaryotic cells. Previous studies have shown that m6A plays a critical role under both normal physiological and pathological conditions. This review systematically reviews the latest research advancements on the roles and mechanisms of m6A regulatory factors in normal hematopoiesis and ...
Xi Chen +5 more
wiley +1 more source
Shared sequence features of IAPs suppressed by Nxf1 alleles.
, 2015 Alignment of IAPs whose effects on host gene expression were modified by either congenic or genome edited Nxf1 alleles suggests that most of the IAP sequence is not required for either mutagenic potential or suppression by Nxf1.
Kevin D. Ross (716891) +4 more
core +1 more source
Gammaretroviral pol sequences act in cis to direct polysome loading and NXF1/NXT-dependent protein production by gag-encoded RNA [PDF]
, 2014 BACKGROUND: All retroviruses synthesize essential proteins via alternatively spliced mRNAs. Retrovirus genera, though, exploit different mechanisms to coordinate the synthesis of proteins from alternatively spliced mRNAs.
Bartels, Hanni, Luban, Jeremy
core +1 more source
Clinical and Translational Medicine, Volume 14, Issue 8, August 2024.The YTH domain protein family regulates innate and adaptive immunity through regulating multiple immune cells and plays a role in anti‐tumour immunity. The YTH domain protein family influences the tumour immune microenvironment by targeting YAP and metabolic mechanisms, promoting immune escape and metastasis.
Fenghe Li +7 more
wiley +1 more source
IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs
eLife, 2017 Expression of inflammatory genes is determined in part by post-transcriptional regulation of mRNA metabolism but how stimulus- and transcript-dependent nuclear export influence is poorly understood.
Hao Zhou +25 more
doaj +1 more source