Results 101 to 110 of about 2,530 (193)

The location of Nxf1:Chtop interactions are altered following transcription inhibition.

, 2013
Representative NFRET images of HeLa cells coexpressing Chtop-ECFP and Nxf1-EYFP in the absence (A) or presence of actinomycin D treatment (B). The arrows indicate the position of the line scan which was used to quantitate the Chtop-ECFP and NFRET ...
I-Fang Teng (425555), Stuart A. Wilson (233570)   +1 more
core   +1 more source

The FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export

Cell Reports
Summary: Fanconi anemia (FA) is characterized by congenital abnormalities, bone marrow failure, and cancer susceptibility. The central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for ...
Anne Olazabal-Herrero, Boxue He, Youngho Kwon, Abhishek K. Gupta, Arijit Dutta, Yuxin Huang, Prajwal Boddu, Zhuobin Liang, Fengshan Liang, Yaqun Teng, Li Lan, Xiaoyong Chen, Huadong Pei, Manoj M. Pillai, Patrick Sung, Gary M. Kupfer   +15 more
doaj   +1 more source

TERC promotes non-small cell lung cancer progression by facilitating the nuclear localization of TERT

iScience
Summary: The core of telomerase consists of the protein subunit telomerase reverse transcriptase (TERT) and the telomerase RNA component (TERC). So far, the role of TERC in cancer development has remained elusive.
Haohui Sun, Xiaodi Li, Qian Long, Xiaonan Wang, Wancui Zhu, Enni Chen, Wenhao Zhou, Han Yang, Chuyang Huang, Wuguo Deng, Miao Chen   +10 more
doaj   +1 more source

Identification of porcine PARP11 as a restricted factor for pseudorabies virus

Frontiers in Cellular and Infection Microbiology
IntroductionPRV infection in swine can cause devastating disease and pose a potential threat to humans. Advancing the interplay between PRV and host is essential to elucidate the pathogenic mechanism of PRV and identify novel anti-PRV targets ...
Chunyun Qi, Dehua Zhao, Xi Wang, Lanxin Hu, Yao Wang, Heyong Wu, Feng Li, Jian Zhou, Tianyi Zhang, Aosi Qi, Yuran Huo, Qiuse Tu, Shuyu Zhong, Hongming Yuan, Hongming Yuan, Hongming Yuan, Dongmei Lv, Dongmei Lv, Dongmei Lv, Shouqing Yan, Hongsheng Ouyang, Hongsheng Ouyang, Hongsheng Ouyang, Hongsheng Ouyang, Daxin Pang, Daxin Pang, Daxin Pang, Zicong Xie, Zicong Xie, Zicong Xie   +29 more
doaj   +1 more source

A Systems Biology Analysis of Chronic Lymphocytic Leukemia

Onco
Whole-genome sequencing has revealed that TP53, NOTCH1, ATM, SF3B1, BIRC3, ABL, NXF1, BCR, and ZAP70 are often mutated in CLL, but not consistently across all CLL patients.
Giulia Pozzati, Jinrui Zhou, Hananel Hazan, Giannoula Lakka Klement, Hava T. Siegelmann, Jack A. Tuszynski, Edward A. Rietman   +6 more
doaj   +1 more source

HBV core protein (HBc) can physically and specifically associate with the cellular NXF1-p15 complex via the NES (nuclear export signal) motif of HBc arginine rich domain (ARD).

, 2014
A)Upper panel: Full-length HBc (HBc 183) consists of a capsid assembly domain and an arginine rich domain (amino acid 147–183). Lower panel: HuH-7 cells were co-transfected with an HBV genome and a p15-Flag expression vector.
Chiaho Shih (172769), Er-Yi Huang (238731), Pei-Yi Su (238733), Hung-Cheng Li (238730), Ching-Chun Yang (238735)   +4 more
core   +1 more source

Suppression of distinct IAP structural classes by Nxf1^CAST.

, 2015
* Full list of elements by class is given in S1 Table** p-values from the Wilcoxon rank sum test for all paired measurements in the class*** False Discovery Rate q-value from the Benjamini-Hochberg method.1 Deletions that remove at least half of the pol ...
Kevin D. Ross (716891), Kasey R. Hutt (481260), Gene W. Yeo (260262), Dorothy Concepcion (264617), Bruce A. Hamilton (172757)   +4 more
core   +1 more source

Both NXF1 and p15 can contribute to the efficient nuclear export of HBV pgRNA.

, 2014
A)Upper panel: A cartoon illustrates an HBV pgRNA reporter plasmid containing a Renilla luciferase gene inserted into a major intron of HBV pgRNA [25]. Lower panel: HuH-7 cells were co-transfected with an HBV pgRNA reporter plasmid and siRNAs.
Chiaho Shih (172769), Er-Yi Huang (238731), Pei-Yi Su (238733), Hung-Cheng Li (238730), Ching-Chun Yang (238735)   +4 more
core   +1 more source

Exploring Differentially Methylated Genes among Preterm Birth and Full-Term Birth

Lifestyle Genomics
Introduction: Preterm birth (PTB) is a major contributor to neonatal morbidity and mortality. DNA methylation plays a critical role in fetal development and may serve as an epigenetic biomarker for PTB.
Aleem Razzaq, Razan ElKahlout, Gheyath K. Nasrallah, Faisal E. Ibrahim, Muthanna Samara, Hatem Zayed, Palli Valapila Abdulrouf, Rana Al-Jurf, Ahmed Najjar, Thomas Farrell, M. Walid Qoronfleh, Hilal Al Rifai, Nader Al-Dewik   +12 more
doaj   +1 more source

Adamts13^S is suppressed by congenic Nxf1^CAST.

, 2015
(A) Alignment of Adamts13 protein domains to their corresponding exons in Adamts13L and Adamts13S shows loss of two thrombospondin (TSP) and two CUB domains from Adamts13S, which terminates in an intronic IAP sequence.
Kevin D. Ross (716891), Kasey R. Hutt (481260), Gene W. Yeo (260262), Dorothy Concepcion (264617), Bruce A. Hamilton (172757)   +4 more
core   +1 more source