Results 61 to 70 of about 2,530 (193)
Ebola virus recruits the nuclear RNA export factor NXF1 for viral mRNA export from inclusion bodies
, 2022 Ebola virus (EBOV) causes severe haemorrhagic fevers in humans with limited treatment options. Virus-host interactions are promising targets for the development of broadly acting antivirals, but knowledge of host factors involved in the EBOV life cycle ...
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Multiple Export Mechanisms for mRNAs
Cells, 2015 Nuclear mRNA export plays an important role in gene expression. We describe the mechanisms of mRNA export including the importance of mRNP assembly, docking with the nuclear basket of the nuclear pore complex (NPC), transit through the central channel of
Mildred Delaleau, Katherine L. B. Borden
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Acta Crystallographica Section D, Volume 81, Issue 11, Page 630-645, November 2025.Two crystallographic fragment screening campaigns against SARS‐CoV‐2 nonstructural protein 1 resulted in the identification of 21 new hits.Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) continues to threaten global health. This underpins the need for novel therapeutics against this virus.
Frank Lennartz +9 more
wiley +1 more source
Erratum: TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export [PDF]
Nature Communications, 2013 Nature Communications 3: Article number: 1006 (2012); Published: 14 August 2012; Updated: 17 October 2013. This Article contains errors in Figs 6 and 7 that were introduced during the production process. In Fig. 6a, the lane labels on the upper right blot are not aligned correctly with the corresponding lanes.
Nicolas Viphakone +7 more
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Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.The interaction between m6A and APA is mediated by the m6A regulator IGF2BP2 and the APA factor CPSF6 The transcripts harbouring m6A modification tend to use the proximal polyadenylation signal (PAS) in ovarian cancer (OC) PUM2 promotes the malignant progression of OC through its m6A methylation and APA processing .
Xin Luo +14 more
wiley +1 more source
The consensus 5' splice site motif inhibits mRNA nuclear export. [PDF]
PLoS ONE, 2015 In eukaryotes, mRNAs are synthesized in the nucleus and then exported to the cytoplasm where they are translated into proteins. We have mapped an element, which when present in the 3'terminal exon or in an unspliced mRNA, inhibits mRNA nuclear export ...
Eliza S Lee +3 more
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The FEBS Journal, Volume 292, Issue 11, Page 2715-2736, June 2025.The silencing of transposable elements is mediated by piRNAs through post‐transcriptional and transcriptional regulation. In Drosophila, piRNAs are processed within unique non‐membrane structures: nuage in germline cells and Yb bodies in somatic gonadal cells.
Ritsuko Suyama, Toshie Kai
wiley +1 more source
Advanced Science, Volume 12, Issue 18, May 15, 2025.A model is schematically represented for the major molecular mechanisms by which homocysteine (Hcy) accelerates the nuclear export of circ‐PIAS1‐5, which regulates atherosclerosis by acting as a competing endogenous RNA for miR‐219a‐2‐3p. Hcy enrichment of circ‐PIAS1‐5 leads to YTHDC1 binding to circ‐PIAS1‐5 and promotes its intracellular localization ...
Shengchao Ma +13 more
wiley +1 more source
Вопросы вирусологииIntroduction. Influenza is an acute respiratory viral infectious disease caused by the influenza viruses. Current preventive and therapeutic approaches are of great anti-epidemic importance, but there are a number of problems, such as the rapid emergence
Evgeny A. Pashkov +8 more
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Scientific Reports, 2022 Fused in Sarcoma (FUS) is a nuclear RNA/DNA binding protein that mislocalizes to the cytoplasm in the neurodegenerative diseases ALS and FTD. Despite the existence of FUS pathogenic mutations that result in nuclear import defects, a subset of ALS/FTD ...
Yueh-Lin Tsai +2 more
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