Results 31 to 40 of about 2,530 (193)

Cellular NS1-BP protein interacts with the mRNA export receptor NXF1 to mediate nuclear export of influenza virus M mRNAs [PDF]

Journal of Biological Chemistry
Matthew Esparza, Mary Dasso, Tolga Cagatay   +2 more
exaly   +2 more sources

NXF1 expression in patient tissues and TPR knockdown cells.

, 2021
(A) NXF1 mRNA level in human lung cancer (T) and adjacent non-tumor (N) tissues. Data were extracted from GSE7670, GSE10072 and GSE31210, normalized to the median value of the non-tumor tissues in each dataset, and compiled for analysis.
Qian Long (3417518), Haohui Sun (11726351), Dingbo Shi (309220), Melinda S. Borrie (11726348), Wuguo Deng (309226), Changlin Zhang (845777), Marc R. Gartenberg (11726354), Han Yang (704814), Miao Chen (213356)   +8 more
core   +1 more source

AnNXF1mRNA with a retained intron is expressed in hippocampal and neocortical neurons and is translated into a protein that functions as an Nxf1 cofactor

Molecular Biology of the Cell, 2016
The Nxf1 protein is a major nuclear export receptor for the transport of mRNA, and it also is essential for export of retroviral mRNAs with retained introns. In the latter case, it binds to RNA elements known as constitutive transport elements (CTEs) and functions in conjunction with a cofactor known as Nxt1.
Li, Ying, Bor, Yeou-cherng, Fitzgerald, Mark P., Lee, Kevin S., Rekosh, David, Hammarskjold, Marie-Louise   +5 more
openaire   +2 more sources

Retroviral Constitutive Transport Element Evolved from Cellular TAP(NXF1)-Binding Sequences [PDF]

Journal of Virology, 2001
ABSTRACT The constitutive transport element (CTE) of type D retroviruses serves as a signal of nuclear export of unspliced viral RNAs. The human TAP(NXF1) protein, a cellular mRNA export factor, directly binds to CTE and mediates nuclear export of CTE-containing RNAs.
A S, Zolotukhin, D, Michalowski, S, Smulevitch, B K, Felber   +3 more
openaire   +2 more sources

Intranuclear binding in space and time of exon junction complex and NXF1 to premRNPs/mRNPs in vivo [PDF]

Journal of Cell Biology, 2015
Eukaryotic gene expression requires the ordered association of numerous factors with precursor messenger RNAs (premRNAs)/messenger RNAs (mRNAs) to achieve efficiency and regulation. Here, we use the Balbiani ring (BR) genes to demonstrate the temporal and spatial association of the exon junction complex (EJC) core with gene-specific endogenous premRNAs
Björk, Petra, Persson, Jan-Olov, Wieslander, Lars   +2 more
openaire   +2 more sources

Effects of mutations in the effector domain of influenza A virus NS1 protein

BMC Research Notes, 2018
Objective The multifunctional NS1 protein of influenza A virus has roles in antagonising cellular innate immune responses and promoting viral gene expression.
Carina F. Pereira, Helen M. Wise, Dominic Kurian, Rute M. Pinto, Maria J. Amorim, Andrew C. Gill, Paul Digard   +6 more
doaj   +1 more source

A role for NXF1 in tRNA nuclear export.

, 2021
(A) Interaction between NXF1 and tRNAs. RIP assay was performed with α-NXF1 or α-XPO1 on A549 cell lysates. RIP with IgG served as control. RT-qPCR was performed to measure the amount of tRNAGlu(CTC), tRNATyr(GTA), tRNAHis(GTG), tRNALeu(CAG), tRNAGly(CCC)
Qian Long (3417518), Haohui Sun (11726351), Dingbo Shi (309220), Melinda S. Borrie (11726348), Wuguo Deng (309226), Changlin Zhang (845777), Marc R. Gartenberg (11726354), Han Yang (704814), Miao Chen (213356)   +8 more
core   +1 more source

The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function

Nature Communications, 2023
PGC-1α plays a central role in maintaining mitochondrial and energy metabolism homeostasis, linking external stimuli to transcriptional co-activation of genes involved in adaptive and age-related pathways.
Simeon R. Mihaylov, Lydia M. Castelli, Ya-Hui Lin, Aytac Gül, Nikita Soni, Christopher Hastings, Helen R. Flynn, Oana Păun, Mark J. Dickman, Ambrosius P. Snijders, Robert Goldstone, Oliver Bandmann, Tatyana A. Shelkovnikova, Heather Mortiboys, Sila K. Ultanir, Guillaume M. Hautbergue   +15 more
doaj   +1 more source

Depletion of NXF1 impairs SG formation.

, 2022
Antibody staining of Rin (red) of S2 cells treated with control dsRNA or NXF1 dsRNA (for 72 hrs) followed by one-hour treatment in the presence or absence of 500 μM sodium arsenite. Hoechst staining is shown in blue. (TIF)
Raul Andino (17309), Xinying Wang (436220), Arabinda Nayak (14204812), Marli Vlok (11895724), Jibin Sadasivan (14204809), Eric Jan (155988)   +5 more
core   +1 more source

Impact of Nuclear Export Pathway on Cytoplasmic HIV-1 RNA Transport Mechanism and Distribution

mBio, 2020
HIV-1 full-length RNA (referred to as HIV-1 RNA here) serves as the viral genome in virions and as a template for Gag/Gag-Pol translation. We previously showed that HIV-1 RNA, which is exported via the CRM1 pathway, travels in the cytoplasm mainly ...
Jianbo Chen, Chijioke Umunnakwe, David Q. Sun, Olga A. Nikolaitchik, Vinay K. Pathak, Ben Berkhout, Atze T. Das, Wei-Shau Hu   +7 more
doaj   +1 more source