RNAi Screen and Proteomics Reveal NXF1 as a Novel Regulator of IRF5 Signaling [PDF]
Scientific Reports, 2017 Interferon regulatory factor 5 (IRF5) is a key transcription factor of innate immunity, which plays an important role in host restriction to viral infection and inflammation.
Bishi Fu +8 more
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Nxf1 natural variant E610G is a semi-dominant suppressor of IAP-induced RNA processing defects. [PDF]
PLoS Genetics, 2015 Endogenous retroviruses and retrotransposons contribute functional genetic variation in animal genomes. In mice, Intracisternal A Particles (IAPs) are a frequent source of both new mutations and polymorphism across laboratory strains.
Dorothy Concepcion +4 more
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Multipotent genetic suppression of retrotransposon-induced mutations by Nxf1 through fine-tuning of alternative splicing. [PDF]
PLoS Genetics, 2009 Cellular gene expression machinery has coevolved with molecular parasites, such as viruses and transposons, which rely on host cells for their expression and reproduction.
Dorothy Concepcion +2 more
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SR proteins are NXF1 adaptors that link alternative RNA processing to mRNA export [PDF]
Genes & Development, 2016 Nuclear export factor 1 (NXF1) exports mRNA to the cytoplasm after recruitment to mRNA by specific adaptor proteins. How and why cells use numerous different export adaptors is poorly understood.
Botti, V. +19 more
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Cells, 2021 Drosophila melanogaster sbr (small bristles) is an orthologue of the Nxf1 (nuclear export factor 1) genes in different Opisthokonta. The known function of Nxf1 genes is the export of various mRNAs from the nucleus to the cytoplasm.
Ludmila Mamon +3 more
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Head-to-Tail Intramolecular Interaction of Herpes Simplex Virus Type 1 Regulatory Protein ICP27 Is Important for Its Interaction with Cellular mRNA Export Receptor TAP/NXF1 [PDF]
mBio, 2010 Herpes simplex virus type 1 (HSV-1) protein ICP27 has many important functions during infection that are achieved through interactions with a number of cellular proteins.
Felicia P. Hernandez +1 more
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The Tpr protein regulates export of mRNAs with retained introns that traffic through the Nxf1 pathway [PDF]
RNA, 2011 Post-transcriptional regulation of mRNA includes restriction mechanisms to prevent export and expression of mRNAs that are incompletely spliced. Here we present evidence that the mammalian protein Tpr is involved in this restriction. To study the role of
Yeou-Cherng Bor +3 more
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SUN5, a testis-specific nuclear membrane protein, participates in recruitment and export of nuclear mRNA in spermatogenesis [PDF]
Acta Biochimica et Biophysica SinicaSUN5, a testis-specific gene, is associated with acephalic spermatozoa syndrome (ASS). Here, we demonstrate that SUN5 is involved in mRNA export. In Sun5-knockout mice (Sun5–/–), poly(A)+ RNA accumulates in the nuclei of germ cells, leading to reduced ...
He Xiyi +7 more
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Export of Adenoviral Late mRNA from the Nucleus Requires the Nxf1/Tap Export Receptor [PDF]
Journal of Virology, 2011 One important function of the human adenovirus E1B 55-kDa protein is induction of selective nuclear export of viral late mRNAs. This protein interacts with the viral E4 Orf6 and four cellular proteins to form an infected-cell-specific E3 ubiquitin ligase.
S. J. Flint +2 more
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MIR4726EccDNA drives bortezomib resistance in multiple myeloma by enhancing MIR4726-5p/NXF1/NKIRAS2 axis dependent autophagy [PDF]
Cell Communication and SignalingBackground Despite many new drugs, multiple myeloma (MM) remains an incurable plasma cell malignancy, and drug resistance is a long-standing topic in this field. Characterized by efficient transcription without being limited by the double helix structure
Fangfang Li +5 more
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