Results 21 to 30 of about 2,530 (193)
Varicella-zoster virus IE4 protein interacts with SR proteins and exports mRNAs through the TAP/NXF1 pathway. [PDF]
PLoS ONE, 2009 Available data suggest that the Varicella-Zoster virus (VZV) IE4 protein acts as an important regulator on VZV and cellular genes expression and could exert its functions at post-transcriptional level.
Isabelle Ote +7 more
doaj +3 more sources
Arginine methylation of REF/ALY promotes efficient handover of mRNA to TAP/NXF1 [PDF]
Nucleic Acids Research, 2010 The REF/ALY mRNA export adaptor binds TAP/ NXF1 via an arginine-rich region, which overlaps with its RNA-binding domain. When TAP binds a REF:RNA complex, it triggers transfer of the RNA from REF to TAP.
Hung, M.L. +9 more
core +5 more sources
Individual influenza A virus mRNAs show differential dependence on cellular NXF1/TAP for their nuclear export [PDF]
Journal of General Virology, 2010 The influenza A virus RNA-dependent RNA polymerase produces capped and polyadenylated mRNAs in the nucleus of infected cells that resemble mature cellular mRNAs, but are made by very different mechanisms.
Read, E.K.C., Digard, P.
core +4 more sources
Журнал микробиологии, эпидемиологии и иммунобиологииIntroduction. Among infectious lesions of the upper respiratory tract and lungs, the leading positions are occupied by infections associated with the influenza A virus.
Evgenij A. Pashkov +7 more
doaj +2 more sources
Pathogens, 2021 Non-structural protein 1 (Nsp1) is a virulence factor found in all beta coronaviruses (b-CoVs). Recent studies have shown that Nsp1 of SARS-CoV-2 virus interacts with the nuclear export receptor complex, which includes nuclear RNA export factor 1 (NXF1 ...
Sona Vasudevan, James N. Baraniuk
doaj +1 more source
U2AF Participates in the Binding of TAP (NXF1) to mRNA [PDF]
Journal of Biological Chemistry, 2002 TAP/NXF1 is a conserved mRNA export receptor serving as a link between messenger ribonucleoproteins (mRNPs) and the nuclear pore complex. The mechanism by which TAP recognizes its export substrate is unclear. We show here that TAP is added to spliced mRNP in human cells. We identified a distinct region of TAP that targets it to mRNP.
Andrei S, Zolotukhin +4 more
openaire +2 more sources
A natural allele of Nxf1 suppresses retrovirus insertional mutations [PDF]
Nature Genetics, 2003 Endogenous retroviruses have shaped the evolution of mammalian genomes. Host genes that control the effects of retrovirus insertions are therefore of great interest. The modifier-of-vibrator-1 locus (Mvb1) controls levels of correctly processed mRNA from genes mutated by endogenous retrovirus insertions into introns, including the Pitpn(vb) tremor ...
Jennifer A, Floyd +13 more
openaire +2 more sources
ICP27 Recruits Aly/REF but Not TAP/NXF1 to Herpes Simplex Virus Type 1 Transcription Sites although TAP/NXF1 Is Required for ICP27 Export [PDF]
Journal of Virology, 2005 ABSTRACT Herpes simplex virus type 1 (HSV-1) protein ICP27 interacts with the cellular export adaptor protein Aly/REF, which is part of the exon junction complex implicated in cellular mRNA export. We previously reported that Aly/REF was no longer associated with splicing factor SC35 sites during infection but instead colocalized with ICP27 ...
I-Hsiung Brandon, Chen +3 more
openaire +2 more sources
iScience, 2021 Summary: Heterogeneous nuclear ribonucleoproteins (hnRNPs) play critical roles in the nuclear export, splicing, and sensing of RNA. However, the role of heterogeneous nuclear ribonucleoprotein A/B (hnRNPAB) is poorly understood.
Xingbo Wang +7 more
doaj +1 more source
Mapping interactions between mRNA export factors in living cells. [PDF]
PLoS ONE, 2013 The TREX complex couples nuclear mRNA processing events with subsequent export to the cytoplasm. TREX also acts as a binding platform for the mRNA export receptor Nxf1.
I-Fang Teng, Stuart A Wilson
doaj +1 more source