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An elevated level of the mRNA exporter Mex67-Mtr2 in nuclear mRNPs impairs nuclear mRNA export. [PDF]
Nucleic Acids ResAbstract In eukaryotes, a crucial step in gene expression is the export of the mRNA out of nucleus. The conserved mRNA exporter Mex67-Mtr2 (NXF1-NXT1 in human) is a key factor in this process. In S.
Stefanyshena N, Sträßer K.
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Seminars in Cell & Developmental Biology, 2014 Release of properly processed and assembled mRNPs from the actively transcribing genes, movement of the mRNPs through the interchromatin and interaction with the Nuclear Pore Complexes, leading to cytoplasmic export, are essential steps of eukaryotic gene expression. Here, we review these intranuclear gene expression steps.
Björk P, Wieslander L
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Dynamics of transcription and mRNA export [PDF]
Current Opinion in Cell Biology, 2005 Understanding the different molecular mechanisms responsible for gene expression has been a central interest of molecular biologists for several decades. Transcription, the initial step of gene expression, consists of converting the genetic code into a dynamic messenger RNA that will specify a required cellular function following translocation to the ...
Xavier, Darzacq +2 more
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mRNA nuclear export at a glance [PDF]
Journal of Cell Science, 2009 Eukaryotic gene expression is controlled by multiple mechanisms, and its regulation is central for physiological responses to extracellular and intracellular signals. An essential step in this process involves the movement of mRNA transcripts from the site of synthesis in the nucleus to ...
Sean R, Carmody, Susan R, Wente
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Chemical intervention of influenza virus mRNA nuclear export.
PLoS Pathogens, 2020 Influenza A viruses are human pathogens with limited therapeutic options. Therefore, it is crucial to devise strategies for the identification of new classes of antiviral medications. The influenza A virus genome is constituted of 8 RNA segments.
Matthew Esparza +18 more
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Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. [PDF]
PLoS Pathogens, 2008 A cellular pre-mRNA undergoes various post-transcriptional processing events, including capping, splicing and polyadenylation prior to nuclear export.
James R Boyne +2 more
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Structure of the human core transcription-export complex reveals a hub for multivalent interactions
eLife, 2020 The export of mRNA from nucleus to cytoplasm requires the conserved and essential transcription and export (TREX) complex (THO–UAP56/DDX39B–ALYREF). TREX selectively binds mRNA maturation marks and licenses mRNA for nuclear export by loading the export ...
Thomas Pühringer +6 more
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Mapping interactions between mRNA export factors in living cells. [PDF]
PLoS ONE, 2013 The TREX complex couples nuclear mRNA processing events with subsequent export to the cytoplasm. TREX also acts as a binding platform for the mRNA export receptor Nxf1.
I-Fang Teng, Stuart A Wilson
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Viruses, 2013 Nuclear mRNA export is a highly complex and regulated process in cells. Cellular transcripts must undergo successful maturation processes, including splicing, 5'-, and 3'-end processing, which are essential for assembly of an export competent ...
Adrian Whitehouse +3 more
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PLoS Pathogens, 2011 The hTREX complex mediates cellular bulk mRNA nuclear export by recruiting the nuclear export factor, TAP, via a direct interaction with the export adaptor, Aly.
Brian R Jackson +9 more
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