Results 41 to 50 of about 881,660 (270)

Identity Elements Used in Export of mRNAs [PDF]

Molecular Cell, 2002
Different classes of RNA are exported from the nucleus by distinct factors. We demonstrate that U1 snRNA is exported like an mRNA on insertion of a pre-mRNA intron or either sense or antisense mRNA exon sequences. mRNA-specific factors are recruited onto the spliced or elongated U1 RNA whereas U snRNA-specific factors are not, suggesting that an ...
Ohno, Mutsuhito, Segref, Alexandra, Kuersten, Scott, Mattaj, Iain W.   +3 more
openaire   +2 more sources

Cell type difference in influenza a viral mRNA nuclear export [PDF]

, 2013
The focus of this thesis research was to clarify the role of host Nxf1 in influenza viral mRNA nuclear export. This study aims to define the nuclear mRNA export pathways of influenza viral mRNA. If viral mRNAs are discovered to utilize neither known mRNA
Larsen, Sean William
core   +7 more sources

ZC3HC1 has many functions distinct from TPR and is dispensable for TPR localisation to the nuclear basket [version 2; peer review: 1 approved, 4 approved with reservations]

Wellcome Open Research
Background The nuclear basket is a ‘fishtrap’-like structure on the nucleoplasmic face of the nuclear pore complex which has been implicated in diverse functions including RNA export, heterochromatin organisation, and mitosis. Recently, a novel component
Wendy A Bickmore, Juan Carlos Acosta, Bethany M Bartlett   +2 more
doaj   +1 more source

The function of the inner nuclear envelope protein SUN1 in mRNA export is regulated by phosphorylation

Scientific Reports, 2017
SUN1, a component of the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex, functions in mammalian mRNA export through the NXF1-dependent pathway. It associates with mRNP complexes by direct interaction with NXF1.
Ping Li, Maria Stumpf, Rolf Müller, Ludwig Eichinger, Gernot Glöckner, Angelika A. Noegel   +5 more
doaj   +1 more source

An essential nuclear protein in trypanosomes is a component of mRNA transcription/export pathway. [PDF]

PLoS ONE, 2011
In eukaryotic cells, different RNA species are exported from the nucleus via specialized pathways. The mRNA export machinery is highly integrated with mRNA processing, and includes a different set of nuclear transport adaptors as well as other mRNA ...
Mariana Serpeloni, Carolina Borsoi Moraes, João Renato Carvalho Muniz, Maria Cristina Machado Motta, Augusto Savio Peixoto Ramos, Rafael Luis Kessler, Alexandre Haruo Inoue, Wanderson Duarte daRocha, Sueli Fumie Yamada-Ogatta, Stenio Perdigão Fragoso, Samuel Goldenberg, Lucio H Freitas-Junior, Andréa Rodrigues Avila   +12 more
doaj   +1 more source

ZC3HC1 has functions distinct from TPR and is dispensable for TPR localisation to the nuclear basket [version 1; peer review: 1 approved, 2 approved with reservations]

Wellcome Open Research
Background The nuclear basket is a ‘fishtrap’-like structure on the nucleoplasmic face of the nuclear pore complex which has been implicated in diverse functions including RNA export, heterochromatin organisation, and mitosis. Recently, a novel component
Wendy A Bickmore, Juan Carlos Acosta, Bethany M Bartlett   +2 more
doaj   +1 more source

Cryo-EM structure of the CBC-ALYREF complex

eLife
In eukaryotes, RNAs transcribed by RNA Pol II are modified at the 5′ end with a 7-methylguanosine (m7G) cap, which is recognized by the nuclear cap binding complex (CBC). The CBC plays multiple important roles in mRNA metabolism, including transcription,
Bradley P Clarke, Alexia E Angelos, Menghan Mei, Pate S Hill, Yihu Xie, Yi Ren   +5 more
doaj   +1 more source

mRNA nuclear export and human disease [PDF]

Disease Models & Mechanisms, 2008
Export of mRNA from the nucleus is a central process in eukaryotic gene expression that has been implicated in several human diseases. Much of our understanding of how an mRNA is transported to the cytoplasm is derived from studies using yeast and fly models.
Jessica A, Hurt, Pamela A, Silver
openaire   +2 more sources

The Kaposi’s sarcoma-associated herpesvirus ORF57 protein and its multiple roles in mRNA biogenesis

Frontiers in Microbiology, 2012
Post-transcriptional events which regulate mRNA biogenesis are fundamental to the control of gene expression. A nascent mRNA is therefore steered through multimeric RNA-protein complexes that mediate its capping, splicing, polyadenylation, nuclear export
Brian R Jackson, Marko eNoerenberg, Adrian eWhitehouse   +2 more
doaj   +1 more source

Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly

Cell Reports, 2023
Summary: mRNA in eukaryotic cells is packaged into highly compacted ribonucleoprotein particles (mRNPs) in the nucleus and exported to the cytoplasm for translation.
Yihu Xie, Shengyan Gao, Ke Zhang, Prasanna Bhat, Bradley P. Clarke, Kimberly Batten, Menghan Mei, Matthew Gazzara, Jerry W. Shay, Kristen W. Lynch, Alexia E. Angelos, Pate S. Hill, Austin L. Ivey, Beatriz M.A. Fontoura, Yi Ren   +14 more
doaj   +1 more source