Results 11 to 20 of about 110,633 (258)
Molecular biology: Mediating transcription and RNA export. [PDF]
Nature, 2015 Rubin JD, Taatjes DJ.
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Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly
Cell Reports, 2023 Summary: mRNA in eukaryotic cells is packaged into highly compacted ribonucleoprotein particles (mRNPs) in the nucleus and exported to the cytoplasm for translation.
Yihu Xie +14 more
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RNA Processing and Export [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 Messenger RNAs undergo 5' capping, splicing, 3'-end processing, and export before translation in the cytoplasm. It has become clear that these mRNA processing events are tightly coupled and have a profound effect on the fate of the resulting transcript.
Sami, Hocine +2 more
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Localization of nucleoporin Tpr to the nuclear pore complex is essential for Tpr mediated regulation of the export of unspliced RNA. [PDF]
PLoS ONE, 2012 Nucleoporin Tpr is a component of the nuclear pore complex (NPC) that localizes exclusively to intranuclear filaments. Tpr functions as a scaffolding element in the nuclear phase of the NPC and plays a role in mitotic spindle checkpoint signalling ...
Kalpana Rajanala, Vinay Kumar Nandicoori
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Genes & Development, 1998 RNA export is the process by which RNAs are transported to the cytoplasm after synthesis, processing, and RNP assembly within the nucleus. The primary focus of this review is mRNA export with particular attention paid to the yeast Saccharomyces cerevisiae.
Stutz F, Rosbash M
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Biology of the Cell, 2004 Abstract A defining feature of eukaryotic cells is the presence of a nuclear envelope separating transcription and DNA replication in the nucleus from the site of protein synthesis in the cytoplasm. The regulation of gene expression relies in part on the controlled exchange of molecules between these two compartments.
Rodriguez, Manuel S +2 more
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Impact of Nuclear Export Pathway on Cytoplasmic HIV-1 RNA Transport Mechanism and Distribution
mBio, 2020 HIV-1 full-length RNA (referred to as HIV-1 RNA here) serves as the viral genome in virions and as a template for Gag/Gag-Pol translation. We previously showed that HIV-1 RNA, which is exported via the CRM1 pathway, travels in the cytoplasm mainly ...
Jianbo Chen +7 more
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hnRNPA3 regulates hESCs pluripotency through modulating mRNA export [PDF]
Jichu yixue yu linchuang, 2021 Objective To explore the biological function of RNA binding protein heterogeneous nuclear ribonucleoprotein A3(hnRNPA3) in the maintenance of pluripotency of human embryonic stem cells(hESCs) and to reveal its new mechanism in RNA transport.
YANG Jia-bin, CHEN Zhong-yang, ZHOU Fan-qi, YU Jia, MA Yan-ni
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Competitive and cooperative interactions mediate RNA transfer from herpesvirus saimiri ORF57 to the mammalian export adaptor ALYREF. [PDF]
PLoS Pathogens, 2014 The essential herpesvirus adaptor protein HVS ORF57, which has homologs in all other herpesviruses, promotes viral mRNA export by utilizing the cellular mRNA export machinery.
Richard B Tunnicliffe +4 more
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PLoS Pathogens, 2009 Once transcribed, the nascent full-length RNA of HIV-1 must travel to the appropriate host cell sites to be translated or to find a partner RNA for copackaging to form newly generated viruses. In this report, we sought to delineate the location where HIV-
Michael D Moore +5 more
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