Results 31 to 40 of about 1,828,054 (294)
Controlling protein transport by small molecules [PDF]
, 2011 Many proteins are transported from the nucleus to the cytoplasm by the exportin CRM1, which recognizes cargo proteins through a leucine rich nuclear export signal (NES).
Karl Gademann, Gademann, Karl
core +1 more source
Small Molecule Inhibitors of CRM1
Frontiers in Pharmacology, 2020 The transport through the nuclear pore complex is used by cancer cells to evade tumor-suppressive mechanisms. Several tumor-suppressors have been shown to be excluded from the cell nucleus in cancer cells by the nuclear export receptor CRM1 and abnormal ...
Bibiana I. Ferreira +8 more
doaj +1 more source
Nucleoporin TPR promotes tRNA nuclear export and protein synthesis in lung cancer cells.
PLoS Genetics, 2021 The robust proliferation of cancer cells requires vastly elevated levels of protein synthesis, which relies on a steady supply of aminoacylated tRNAs. Delivery of tRNAs to the cytoplasm is a highly regulated process, but the machinery for tRNA nuclear ...
Miao Chen +8 more
doaj +1 more source
Spelling out the roles of individual nucleoporins in nuclear export of mRNA
Nucleus, 2022 The Nuclear Pore Complex (NPC) represents a critical passage through the nuclear envelope for nuclear import and export that impacts nearly every cellular process at some level.
Mark Tingey +4 more
doaj +1 more source
Nucleocytoplasmic shuttling activity of ataxin-3. [PDF]
PLoS ONE, 2009 Spinocerebellar ataxia type-3, also known as Machado-Joseph Disease (MJD), is one of many inherited neurodegenerative disorders caused by polyglutamine-encoding CAG repeat expansions in otherwise unrelated genes.
Sandra Macedo-Ribeiro +3 more
doaj +1 more source
Cic1p/Nsa3p is required for synthesis and nuclear export of 60S ribosomal subunits [PDF]
, 2003 Cic1p/Nsa3p was previously reported to be associated with the 26S proteasome and required for the degradation of specific substrates, but was also shown to be associated with early pre-60S particles and to be localized to the nucleolus.
Tollervey, D +7 more
core +1 more source
Journal of Lipid Research, 2009 CTP:phosphocholine cytidylyltransferase α (CCTα), the rate-limiting enzyme in the CDP-choline pathway for phosphatidylcholine (PtdCho) synthesis, is activated by translocation to nuclear membranes.
Karsten Gehrig +2 more
doaj +1 more source
Journal of Cell Science, 2003 Eukaryotic cells export several different classes of RNA molecule from the nucleus, where they are transcribed, to the cytoplasm, where the majority participate in different aspects of protein synthesis. It is now clear that these different classes of RNA, including rRNAs, tRNAs, mRNAs and snRNAs, are specifically directed into distinct but in some ...
openaire +2 more sources
Nuclear export, enlightened [PDF]
Proceedings of the National Academy of Sciences, 2012 The physicist Richard Feynman once quipped that the key to solving or making significant progress on a scientific problem was to “find the open channel.” For the cell biological problem of nucleus-to-cytoplasm transport, the literal open channels have long been known: the nuclear pore complexes (NPCs). However, in the metaphorical sense as well, recent
openaire +2 more sources
International Journal of Molecular Sciences, 2022 The relationship between transcription and aging is one that has been studied intensively and experimentally with diverse attempts. However, the impact of the nuclear mRNA export on the aging process following its transcription is still poorly understood, although the nuclear events after transcription are coupled closely with the transcription pathway
Hyun-Sun Park +4 more
openaire +2 more sources