Results 31 to 40 of about 102,700 (257)
Calreticulin Is a Receptor for Nuclear Export [PDF]
The Journal of Cell Biology, 2001 In previous work, we used a permeabilized cell assay that reconstitutes nuclear export of protein kinase inhibitor (PKI) to show that cytosol contains an export activity that is distinct from Crm1 (Holaska, J.M., and B.M. Paschal. 1995. Proc. Natl. Acad. Sci. USA. 95: 14739–14744). Here, we describe the purification and characterization of the activity
J M, Holaska +5 more
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Viruses, 2014 Previously we reported that nuclear export of both unspliced and spliced murine leukemia virus (MLV) transcripts depends on the nuclear export factor (NXF1) pathway.
Toshie Sakuma +2 more
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International Journal of Molecular Sciences, 2022 The relationship between transcription and aging is one that has been studied intensively and experimentally with diverse attempts. However, the impact of the nuclear mRNA export on the aging process following its transcription is still poorly understood, although the nuclear events after transcription are coupled closely with the transcription pathway
Hyun-Sun Park +4 more
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Nuclear dynamics: Formation of bodies and trafficking in plant nuclei
Frontiers in Plant Science, 2022 The existence of the nucleus distinguishes prokaryotes and eukaryotes. Apart from containing most of the genetic material, the nucleus possesses several nuclear bodies composed of protein and RNA molecules.
Eduardo Muñoz-Díaz +3 more
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mRNA nuclear export at a glance [PDF]
Journal of Cell Science, 2009 Eukaryotic gene expression is controlled by multiple mechanisms, and its regulation is central for physiological responses to extracellular and intracellular signals. An essential step in this process involves the movement of mRNA transcripts from the site of synthesis in the nucleus to ...
Sean R, Carmody, Susan R, Wente
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KLF4 Nuclear Export Requires ERK Activation and Initiates Exit from Naive Pluripotency
Stem Cell Reports, 2018 Summary: Cooperative action of a transcription factor complex containing OCT4, SOX2, NANOG, and KLF4 maintains the naive pluripotent state; however, less is known about the mechanisms that disrupt this complex, initiating exit from pluripotency.
Navroop K. Dhaliwal +4 more
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Polyadenylation and nuclear export of mRNAs [PDF]
Journal of Biological Chemistry, 2019 In eukaryotes, the separation of translation from transcription by the nuclear envelope enables mRNA modifications such as capping, splicing, and polyadenylation. These modifications are mediated by a spectrum of ribonuclear proteins that associate with preRNA transcripts, coordinating the different steps and coupling them to nuclear export, ensuring ...
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Nuclear RNA export in yeast [PDF]
FEBS Letters, 1999 Eukaryotic cells massively exchange macromolecules (proteins and RNAs) between the nucleus and cytoplasm through the nuclear pore complexes. Whereas a mechanistic picture emerges of how proteins are imported into and exported from the nucleus, less is known about nuclear exit of the different classes of RNAs. However, the yeast Saccharomyces cerevisiae
Sträßer, Katja, Hurt, Ed
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Analysis of the Activity of Nuclear Export Signals Using Fluorescent BSA Conjugates
BioTechniques, 2002 Here we demonstrate that fluorescein-labeled BSA conjugated with a mixture of nuclear import and export signals can be used to evaluate export activity.
Carl M. Feldherr, Debra Akin
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Nuclear Export of Messenger RNA [PDF]
Genes, 2015 Transport of messenger RNA (mRNA) from the nucleus to the cytoplasm is an essential step of eukaryotic gene expression. In the cell nucleus, a precursor mRNA undergoes a series of processing steps, including capping at the 5' ends, splicing and cleavage/polyadenylation at the 3' ends.
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