Results 31 to 40 of about 315,054 (297)
Nuclear DDX3 expression predicts poor outcome in colorectal and breast cancer [PDF]
, 2017 Purpose: DEAD box protein 3 (DDX3) is an RNA helicase with oncogenic properties that shuttles between the cytoplasm and nucleus. The majority of DDX3 is found in the cytoplasm, but a subset of tumors has distinct nuclear DDX3 localization of yet unknown ...
Bol, Guus M. +10 more
core +2 more sources
Nucleoporin TPR promotes tRNA nuclear export and protein synthesis in lung cancer cells.
PLoS Genetics, 2021 The robust proliferation of cancer cells requires vastly elevated levels of protein synthesis, which relies on a steady supply of aminoacylated tRNAs. Delivery of tRNAs to the cytoplasm is a highly regulated process, but the machinery for tRNA nuclear ...
Miao Chen +8 more
doaj +1 more source
Nucleocytoplasmic shuttling activity of ataxin-3. [PDF]
PLoS ONE, 2009 Spinocerebellar ataxia type-3, also known as Machado-Joseph Disease (MJD), is one of many inherited neurodegenerative disorders caused by polyglutamine-encoding CAG repeat expansions in otherwise unrelated genes.
Sandra Macedo-Ribeiro +3 more
doaj +1 more source
RNA Nuclear Export: From Neurological Disorders to Cancer [PDF]
, 2017 The presence of a nuclear envelope, also known as nuclear membrane, defines the structural framework of all eukaryotic cells by separating the nucleus, which contains the genetic material, from the cytoplasm where the synthesis of proteins takes place ...
Hautbergue, G.M.
core +1 more source
Pharmacological treatment with inhibitors of nuclear export enhances the antitumor activity of docetaxel in human prostate cancer [PDF]
, 2017 Background and aims: Docetaxel (DTX) modestly increases patient survival of metastatic castration-resistant prostate cancer (mCRPC) due to insurgence of pharmacological resistance. Deregulation of Chromosome Region Maintenance (CRM-1)/ exportin-1 (XPO-1)-
Argueta, Christian +14 more
core +2 more sources
Journal of Lipid Research, 2009 CTP:phosphocholine cytidylyltransferase α (CCTα), the rate-limiting enzyme in the CDP-choline pathway for phosphatidylcholine (PtdCho) synthesis, is activated by translocation to nuclear membranes.
Karsten Gehrig +2 more
doaj +1 more source
A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAs. [PDF]
, 2016 The export of messenger RNAs (mRNAs) is the final of several nuclear posttranscriptional steps of gene expression. The formation of export-competent mRNPs involves the recruitment of export factors that are assumed to facilitate transport of the mature ...
Gehring, NH +4 more
core +1 more source
Viruses, 2014 Previously we reported that nuclear export of both unspliced and spliced murine leukemia virus (MLV) transcripts depends on the nuclear export factor (NXF1) pathway.
Toshie Sakuma +2 more
doaj +1 more source
Nuclear RNA Export Pathways [PDF]
Molecular and Cellular Biology, 2000 One of the most profound differences between prokaryotes and eukaryotes is that only the latter segregate RNA synthesis and protein synthesis into distinct cellular compartments, i.e., into the nucleus and cytoplasm, respectively. This segregation offers opportunities for the regulation of both gene expression and RNA posttranscriptional processing ...
openaire +2 more sources
The Signal Sequence Coding Region Promotes Nuclear Export of mRNA [PDF]
, 2011 In eukaryotic cells, most mRNAs are exported from the nucleus by the transcription export (TREX) complex, which is loaded onto mRNAs after their splicing and capping.
Dias, Anusha P +5 more
core +1 more source