Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2 [PDF]
Open Biology, 2013 The pleckstrin homology (PH) domain is a versatile fold that mediates a variety of protein–protein and protein–phosphatidylinositol lipid interactions. The Ran-binding protein 2 (RanBP2) contains four interspersed Ran GTPase-binding domains (RBDn = 1–4 ...
Hemangi Patil +5 more
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RANBP3 and RAN orchestrate CRM1-mediated nuclear export of hepatitis B virus RNAs [PDF]
Journal of VirologyNuclear export of viral RNAs is essential for the replication of hepatitis B virus (HBV). Our previous study demonstrated that ELAVL1 (embryonic lethal, abnormal vision, Drosophila-like 1) mediates the nuclear export of HBV RNAs via the chromosome region
Mengfei Wang +14 more
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Two Putative Cypovirus-Encoded miRNAs Co-regulate the Host Gene of GTP-Binding Nuclear Protein Ran and Facilitate Virus Replication [PDF]
Frontiers in Physiology, 2021 microRNA (miRNA) plays important roles in regulating various biological processes, including host-pathogen interaction. Recent studies have demonstrated that virus-encoded miRNAs can manipulate host gene expression to ensure viral effective ...
Su Lin +19 more
doaj +3 more sources
Structural characterisation of the nuclear import receptor importin alpha in complex with the bipartite NLS of Prp20. [PDF]
PLoS ONE, 2013 The translocation of macromolecules into the nucleus is a fundamental eukaryotic process, regulating gene expression, cell division and differentiation, but which is impaired in a range of significant diseases including cancer and viral infection.
Noelia Roman +4 more
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The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes. [PDF]
PLoS ONE, 2015 The inner nuclear membrane (INM) protein Nemp1/TMEM194A has previously been suggested to be involved in eye development in Xenopus, and contains two evolutionarily conserved sequences in the transmembrane domains (TMs) and the C-terminal region, named ...
Takashi Shibano +4 more
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RANBP10 promotes glioblastoma progression by regulating the FBXW7/c-Myc pathway
Cell Death and Disease, 2021 RAN binding protein 10 (RANBP10), a ubiquitously expressed and evolutionarily conserved protein, as a RAN-GTP exchange factor (GEF) to regulate several factors involved in cellular progression.
Jianbing Hou +7 more
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Molecular Biomedicine, 2020 Ran (Ras-related nuclear protein) plays several important roles in nucleo-cytoplasmic transport, mitotic spindle formation, nuclear envelope/nuclear pore complex assembly, and other functions in the cytoplasm, as well as in cellular transformation when ...
Jinhan Zhou +7 more
doaj +1 more source
Alteration in endometrial proteins during early- and mid-secretory phases of the cycle in women with unexplained infertility. [PDF]
PLoS ONE, 2014 BACKGROUND: Compromised receptivity of the endometrium is a major cause of unexplained infertility, implantation failure and subclinical pregnancy loss.
Murli Manohar +7 more
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Frontiers in Oncology, 2023 IntroductionArtemisia absinthium (wormwood) exhibits anticancer properties by inhibiting proliferation and causing cell death in breast cancer. Targeted drug delivery of A. absinthium nanoformulation using N-isopropyl acrylamide, N-vinyl pyrrolidone, and
Sana Kauser +4 more
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Structural Insights into How Yrb2p Accelerates the Assembly of the Xpo1p Nuclear Export Complex
Cell Reports, 2014 Proteins and ribonucleoproteins containing a nuclear export signal (NES) assemble with the exportin Xpo1p (yeast CRM1) and Gsp1p-GTP (yeast Ran-GTP) in the nucleus and exit through the nuclear pore complex.
Masako Koyama +2 more
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