Results 1 to 10 of about 29,147 (185)

Two Putative Cypovirus-Encoded miRNAs Co-regulate the Host Gene of GTP-Binding Nuclear Protein Ran and Facilitate Virus Replication [PDF]

Frontiers in Physiology, 2021
microRNA (miRNA) plays important roles in regulating various biological processes, including host-pathogen interaction. Recent studies have demonstrated that virus-encoded miRNAs can manipulate host gene expression to ensure viral effective ...
Su Lin, Su Lin, Yongsheng Wang, Yongsheng Wang, Ze Zhao, Ze Zhao, Wanming Wu, Wanming Wu, Yun Su, Yun Su, Zhendong Zhang, Zhendong Zhang, Manman Shen, Manman Shen, Ping Wu, Ping Wu, Heying Qian, Heying Qian, Xijie Guo, Xijie Guo   +19 more
doaj   +3 more sources

Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2 [PDF]

Open Biology, 2013
The pleckstrin homology (PH) domain is a versatile fold that mediates a variety of protein–protein and protein–phosphatidylinositol lipid interactions. The Ran-binding protein 2 (RanBP2) contains four interspersed Ran GTPase-binding domains (RBDn = 1–4 ...
Hemangi Patil, Kyoung-in Cho, James Lee, Yi Yang, Andrew Orry, Paulo A. Ferreira   +5 more
doaj   +4 more sources

Small GTP-binding protein Ran is regulated by posttranslational lysine acetylation [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance The small GTPase Ran plays fundamental roles in cellular processes such as nucleo-cytoplasmic transport, mitotic spindle formation, and nuclear envelope assembly. Recently, Ran was found to be lysine acetylated, among others, in functionally important regions such as switch I and switch II.
Susanne, de Boor, Philipp, Knyphausen, Nora, Kuhlmann, Sarah, Wroblowski, Julian, Brenig, Lukas, Scislowski, Linda, Baldus, Hendrik, Nolte, Marcus, Krüger, Michael, Lammers   +9 more
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The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes. [PDF]

PLoS ONE, 2015
The inner nuclear membrane (INM) protein Nemp1/TMEM194A has previously been suggested to be involved in eye development in Xenopus, and contains two evolutionarily conserved sequences in the transmembrane domains (TMs) and the C-terminal region, named ...
Takashi Shibano, Hiroshi Mamada, Fumihiko Hakuno, Shin-Ichiro Takahashi, Masanori Taira   +4 more
doaj   +1 more source

Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis. [PDF]

The Journal of cell biology, 1993
Ran/TC4, first identified as a well-conserved gene distantly related to H-RAS, encodes a protein which has recently been shown in yeast and mammalian systems to interact with RCC1, a protein whose function is required for the normal coupling of the completion of DNA synthesis and the initiation of mitosis.
M, Ren, G, Drivas, P, D'Eustachio, M G, Rush   +3 more
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Structural characterisation of the nuclear import receptor importin alpha in complex with the bipartite NLS of Prp20. [PDF]

PLoS ONE, 2013
The translocation of macromolecules into the nucleus is a fundamental eukaryotic process, regulating gene expression, cell division and differentiation, but which is impaired in a range of significant diseases including cancer and viral infection.
Noelia Roman, Mary Christie, Crystall M D Swarbrick, Bostjan Kobe, Jade K Forwood   +4 more
doaj   +1 more source

RANBP10 promotes glioblastoma progression by regulating the FBXW7/c-Myc pathway

Cell Death and Disease, 2021
RAN binding protein 10 (RANBP10), a ubiquitously expressed and evolutionarily conserved protein, as a RAN-GTP exchange factor (GEF) to regulate several factors involved in cellular progression.
Jianbing Hou, Yudong Liu, Pan Huang, Yutao Wang, Dakun Pei, Ruoyue Tan, Yundong Zhang, Hongjuan Cui   +7 more
doaj   +1 more source

Yrb4p, a yeast Ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus [PDF]

The EMBO Journal, 1997
Gsp1p, the essential yeast Ran homologue, is a key regulator of transport across the nuclear pore complex (NPC). We report the identification of Yrb4p, a novel Gsp1p binding protein. The 123 kDa protein was isolated from Saccharomyces cerevisiae cells and found to be related to importin-beta, the mediator of nuclear localization signal (NLS)-dependent ...
Schlenstedt, G., Smirnova, E., Deane, R., Solsbacher, J., Kutay, U., Görlich, D., Ponstingl, H., Bischoff, F.   +7 more
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GEF-independent Ran activation shifts a fraction of the protein to the cytoplasm and promotes cell proliferation

Molecular Biomedicine, 2020
Ran (Ras-related nuclear protein) plays several important roles in nucleo-cytoplasmic transport, mitotic spindle formation, nuclear envelope/nuclear pore complex assembly, and other functions in the cytoplasm, as well as in cellular transformation when ...
Jinhan Zhou, Yuping Tan, Yuqing Zhang, Aiping Tong, Xiaofei Shen, Xiaodong Sun, Da Jia, Qingxiang Sun   +7 more
doaj   +1 more source

Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1. [PDF]

The EMBO Journal, 1995
RCC1 (the regulator of chromosome condensation) stimulates guanine nucleotide dissociation on the Ras-related nuclear protein Ran. Both polypeptides are components of a regulatory pathway that has been implicated in regulating DNA replication, onset of and exit from mitosis, mRNA processing and transport, and import of proteins into the nucleus.
F R, Bischoff, H, Krebber, E, Smirnova, W, Dong, H, Ponstingl   +4 more
openaire   +2 more sources