Results 11 to 20 of about 13,129 (191)

RANBP10 promotes glioblastoma progression by regulating the FBXW7/c-Myc pathway

Cell Death and Disease, 2021
RAN binding protein 10 (RANBP10), a ubiquitously expressed and evolutionarily conserved protein, as a RAN-GTP exchange factor (GEF) to regulate several factors involved in cellular progression.
Jianbing Hou, Yudong Liu, Pan Huang, Yutao Wang, Dakun Pei, Ruoyue Tan, Yundong Zhang, Hongjuan Cui   +7 more
doaj   +1 more source

GEF-independent Ran activation shifts a fraction of the protein to the cytoplasm and promotes cell proliferation

Molecular Biomedicine, 2020
Ran (Ras-related nuclear protein) plays several important roles in nucleo-cytoplasmic transport, mitotic spindle formation, nuclear envelope/nuclear pore complex assembly, and other functions in the cytoplasm, as well as in cellular transformation when ...
Jinhan Zhou, Yuping Tan, Yuqing Zhang, Aiping Tong, Xiaofei Shen, Xiaodong Sun, Da Jia, Qingxiang Sun   +7 more
doaj   +1 more source

Alteration in endometrial proteins during early- and mid-secretory phases of the cycle in women with unexplained infertility. [PDF]

PLoS ONE, 2014
BACKGROUND: Compromised receptivity of the endometrium is a major cause of unexplained infertility, implantation failure and subclinical pregnancy loss.
Murli Manohar, Huma Khan, Vijay Kumar Sirohi, Vinita Das, Anjoo Agarwal, Amita Pandey, Waseem Ahmad Siddiqui, Anila Dwivedi   +7 more
doaj   +1 more source

Secretome profiling of Artemisia absinthium extract-loaded polymeric nanoparticle-treated MCF-7 and MDA-MB-231 revealed perturbation in microtubule assembly and cell migration

Frontiers in Oncology, 2023
IntroductionArtemisia absinthium (wormwood) exhibits anticancer properties by inhibiting proliferation and causing cell death in breast cancer. Targeted drug delivery of A. absinthium nanoformulation using N-isopropyl acrylamide, N-vinyl pyrrolidone, and
Sana Kauser, Mohd Mughees, Irengbam Rocky Mangangcha, Sanskriti Swami, Saima Wajid   +4 more
doaj   +1 more source

Characterization of membrane-bound small GTP-binding proteins from Nicotiana tabacum [PDF]

, 1995
Haizel T, Merkle T, Turck F, Nagy F. Characterization of membrane-bound small GTP-binding proteins from Nicotiana tabacum. Plant Physiology.
Haizel, T, Turck, F, Nagy, F, Haizel, T., Merkle, Thomas, Turck, F., Nagy, F., Merkle, T   +7 more
core   +1 more source

Substrate binding disrupts dimerization and induces nucleotide exchange of the chloroplast GTPase Toc33 [PDF]

, 2011
GTPases act as molecular switches to control many cellular processes, including signalling, protein translation and targeting. Switch activity can be regulated by external effector proteins or intrinsic properties, such as dimerization.
Ivo Tews, Patrick Koenig, Danny J. Schnell, Tews, Ivo, Sinning, Irmgard, Enrico Schleiff, Oreb, Mislav, Schnell, Danny, Koenig, Patrick, Mislav Oreb, Maik S. Sommer, Sommer, Maik S, Wang, Fei, Schnell, Danny J., Schleiff, Enrico, Irmgard Sinning, Sommer, Maik S., Fei Wang, Anja Höfle, Höfle, Anja   +19 more
core   +1 more source

Structural Insights into How Yrb2p Accelerates the Assembly of the Xpo1p Nuclear Export Complex

Cell Reports, 2014
Proteins and ribonucleoproteins containing a nuclear export signal (NES) assemble with the exportin Xpo1p (yeast CRM1) and Gsp1p-GTP (yeast Ran-GTP) in the nucleus and exit through the nuclear pore complex.
Masako Koyama, Natsuki Shirai, Yoshiyuki Matsuura   +2 more
doaj   +1 more source

Comparative Proteomic Analysis of Anti-Cancer Mechanism by Periplocin Treatment in Lung Cancer Cells

Cellular Physiology and Biochemistry, 2014
Background: Periplocin is used for treatment of rheumatoid arthritis, reinforcement of bones and tendons, palpitations or shortness of breath and lower extremity edema in traditional medicine. Our previous findings suggested that periplocin could inhibit
Zejun Lu, Qi Song, Jinliang Yang, Xiangfei Zhao, Xinhong Zhang, Ping Yang, Jingbo Kang   +6 more
doaj   +1 more source

Induction of Ran GTP drives ciliogenesis [PDF]

, 2011
The small GTPase Ran and the importin proteins regulate nucleocytoplasmic transport. New evidence suggests that Ran GTP and the importins are also involved in conveying proteins into cilia.
Martens, Jeffrey R, Sajjan, Uma, Ben Margolis, Margolis, Ben, Shuling Fan, Verhey, Kristen J, Toby W. Hurd, Dishinger, John F, Kristen J. Verhey, Jeffrey R. Martens, Hurd, Toby W, Chia Jen Liu, Eileen L. Whiteman, Uma Sajjan, Whiteman, Eileen L, Liu, Chia Jen, Fan, Shuling, McIntyre, Jeremy C, Jeremy C. McIntyre, John F. Dishinger   +19 more
core   +1 more source

Selective Impairment of a Subset of Ran-GTP-binding Domains of Ran-binding Protein 2 (Ranbp2) Suffices to Recapitulate the Degeneration of the Retinal Pigment Epithelium (RPE) Triggered by Ranbp2 Ablation [PDF]

Journal of Biological Chemistry, 2014
Retinal pigment epithelium (RPE) degeneration underpins diseases triggered by disparate genetic lesions, noxious insults, or both. The pleiotropic Ranbp2 controls the expression of intrinsic and extrinsic pathological stressors impinging on cellular viability. However, the physiological targets and mechanisms controlled by Ranbp2 in tissue homeostasis,
Hemangi, Patil, Arjun, Saha, Eugene, Senda, Kyoung-in, Cho, MdEmdadul, Haque, Minzhong, Yu, Sunny, Qiu, Dosuk, Yoon, Ying, Hao, Neal S, Peachey, Paulo A, Ferreira   +10 more
openaire   +2 more sources