Results 11 to 20 of about 4,434,687 (184)

Conformational States of the Nuclear GTP-Binding Protein Ran and Its Complexes with the Exchange Factor RCC1 and the Effector Protein RanBP1

Biochemistry, 1999
It has been shown before by (31)P NMR that Ras bound to the nonhydrolyzable GTP analogue guanosine 5'-O-(beta, gamma-imidotriphosphate) (GppNHp) exists in two conformations which are rapidly interconverting with a rate constant of 3200 s-1 at 30 degrees C [Geyer, M., et al. (1996) Biochemistry 35, 10308-10320].
Geyer, M., Assheuer, R., Klebe, C., Kuhlmann, J., Becker, J., Wittinghofer, A., Kalbitzer, H.   +6 more
openaire   +4 more sources

Co‐activation of RanGTPase and inhibition of GTP dissociation by Ran‐GTP binding protein RanBP1. [PDF]

The EMBO Journal, 1995
RCC1 (the regulator of chromosome condensation) stimulates guanine nucleotide dissociation on the Ras-related nuclear protein Ran. Both polypeptides are components of a regulatory pathway that has been implicated in regulating DNA replication, onset of and exit from mitosis, mRNA processing and transport, and import of proteins into the nucleus.
F R, Bischoff, H, Krebber, E, Smirnova, W, Dong, H, Ponstingl   +4 more
openaire   +2 more sources

Characterization of membrane-bound small GTP-binding proteins from Nicotiana tabacum [PDF]

, 1995
Haizel T, Merkle T, Turck F, Nagy F. Characterization of membrane-bound small GTP-binding proteins from Nicotiana tabacum. Plant Physiology.
Haizel, T, Turck, F, Nagy, F, Haizel, T., Merkle, Thomas, Turck, F., Nagy, F., Merkle, T   +7 more
core   +1 more source

The chloroplast import receptor Toc34 functions as preprotein-regulated GTPase [PDF]

, 2002
Toc34 is a protein of the chloroplast outer envelope membrane that acts as receptor for preproteins containing a transit sequence. The recognition of preproteins by Toc34 is regulated by GTP binding and phosphorylation.
Soll, J., Jelic, M., Schleiff, E., Motzkus, M., Sveshnikova, N., Hörth, P.   +5 more
core   +1 more source

Comparative Proteomic Analysis of Anti-Cancer Mechanism by Periplocin Treatment in Lung Cancer Cells

Cellular Physiology and Biochemistry, 2014
Background: Periplocin is used for treatment of rheumatoid arthritis, reinforcement of bones and tendons, palpitations or shortness of breath and lower extremity edema in traditional medicine. Our previous findings suggested that periplocin could inhibit
Zejun Lu, Qi Song, Jinliang Yang, Xiangfei Zhao, Xinhong Zhang, Ping Yang, Jingbo Kang   +6 more
doaj   +1 more source

Generation of specific antibodies against the rap1A, rap1B and rap2 small GTP-binding proteins. Analysis of rap and ras proteins in membranes from mammalian cells [PDF]

, 1992
Specific antibodies against rap1A and rap1B small GTP-binding proteins were generated by immunization of rabbits with peptides derived from the C-terminus of the processed proteins.
Schwaner, I., Frank, R., Gausepohl, H., Seifert, Roland, Schultz, Günter, Klinz, F. J.   +5 more
core   +1 more source

Selective Impairment of a Subset of Ran-GTP-binding Domains of Ran-binding Protein 2 (Ranbp2) Suffices to Recapitulate the Degeneration of the Retinal Pigment Epithelium (RPE) Triggered by Ranbp2 Ablation [PDF]

Journal of Biological Chemistry, 2014
Retinal pigment epithelium (RPE) degeneration underpins diseases triggered by disparate genetic lesions, noxious insults, or both. The pleiotropic Ranbp2 controls the expression of intrinsic and extrinsic pathological stressors impinging on cellular viability. However, the physiological targets and mechanisms controlled by Ranbp2 in tissue homeostasis,
Hemangi, Patil, Arjun, Saha, Eugene, Senda, Kyoung-in, Cho, MdEmdadul, Haque, Minzhong, Yu, Sunny, Qiu, Dosuk, Yoon, Ying, Hao, Neal S, Peachey, Paulo A, Ferreira   +10 more
openaire   +2 more sources

The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering [PDF]

, 2004
Glycine receptors (GlyRs) and specific subtypes of GABA(A) receptors are clustered at synapses by the multidomain protein gephyrin, which in turn is translocated to the cell membrane by the GDP-GTP exchange factor collybistin.
Ward, H, Harvey, R.J., Alldred, Melissa J., Smart, T.G., Luscher, B, Duguid, Ian C, Lingenfelter, S E, Duguid, IC, Ward, H., Lingenfelter, Sue E., Alldred, M.J., Harvey, Robert J., Pearce, B R, Lundgren, J.D., Harvey, K, Owen, Michael John, Pearce, Brian R., Beatty, S.E., Smart, Trevor G., Owens, Max J., Keep, N H, Harvey, RJ, Lingenfelter, S.E., Harvey, Robert J, Keep, NH, Lundgren, J, Owen, MJ, Lund University., Ward, Hamish, Smart, T G, Pearce, B.R., Lüscher, Bernhard, Beatty, Sarah E., Lingenfelter, SE, Lundgren, Johan,, Keep, Nicholas H., Lundgren, Johan, Luscher, B., Harvey, K., Smart, TG, Alldred, M J, Beatty, SE, Owen, M J, Beatty, S E, Alldred, MJ, Rees, MI, Harvey, Kirsten, Duguid, I C, Rees, Mark I., Rees, M I, Duguid, I.C., Pearce, BR, Mark Rees, Rees, M.I.   +53 more
core   +1 more source

The RanGTP pathway: from nucleo-cytoplasmic transport to spindle assembly and beyond

Frontiers in Cell and Developmental Biology, 2016
The small GTPase Ran regulates the interaction of transport receptors with a number of cellular cargo proteins. The high affinity binding of the GTP-bound form of Ran to import receptors promotes cargo release, whereas its binding to export receptors ...
Tommaso eCavazza, Tommaso eCavazza, Isabelle eVernos, Isabelle eVernos, Isabelle eVernos   +4 more
doaj   +1 more source

Topological and functional properties of the small GTPases protein interaction network. [PDF]

PLoS ONE, 2012
Small GTP binding proteins of the Ras superfamily (Ras, Rho, Rab, Arf, and Ran) regulate key cellular processes such as signal transduction, cell proliferation, cell motility, and vesicle transport.
Anna Delprato
doaj   +1 more source