Results 31 to 40 of about 13,129 (191)

RanBP1 controls the Ran pathway in mammalian cells through regulation of mitotic RCC1 dynamics [PDF]

, 2020
The Ran GTPase plays critical roles in multiple cellular processes including interphase nucleocytoplasmic transport and mitotic spindle assembly. During mitosis in mammalian cells, GTP-bound Ran (Ran-GTP) is concentrated near mitotic chromatin while GDP ...
Alexei Arnaoutov (260485), Mary Dasso (42707), Ka Chun Yau (9282962), Shane Chen (9282971), Ross Kaufhold (9282968), Vasilisa Aksenova (9282965)   +5 more
core   +1 more source

In Preclinical Model of Ovarian Cancer, the SGK1 Inhibitor SI113 Counteracts the Development of Paclitaxel Resistance and Restores Drug Sensitivity

Translational Oncology, 2019
Ovarian cancer is the second most common gynecological malignancy worldwide. Paclitaxel is particularly important in the therapy of ovarian carcinomas, but the treatment efficacy is counteracted by the development of resistance to chemotherapy.
Lucia D'Antona, Vincenzo Dattilo, Giada Catalogna, Domenica Scumaci, Claudia Vincenza Fiumara, Francesca Musumeci, Giuseppe Perrotti, Silvia Schenone, Rossana Tallerico, Cristina B. Spoleti, Nicola Costa, Rodolfo Iuliano, Giovanni Cuda, Rosario Amato, Nicola Perrotti   +14 more
doaj   +1 more source

RANBP2 (RAN binding protein 2) [PDF]

, 2015
Review on RANBP2 (RAN binding protein 2) , with data on DNA, on the protein encoded, and where the gene is ...
Lavia, Patrizia, Di Cesare, Erica
core   +1 more source

RANBP9 (RAN binding protein 9) [PDF]

, 2012
Review on RANBP9 (RAN binding protein 9), with data on DNA, on the protein encoded, and where the gene is ...
Suresh, B, Baek, KH
core   +1 more source

Unique and differential protein signatures within the mononuclear cells of HIV-1 and HCV mono-infected and co-infected patients

Clinical Proteomics, 2012
Background Pathogenesis of liver damage in patients with HIV and HCV co-infection is complex and multifactorial. Although global awareness regarding HIV-1/HCV co-infection is increasing little is known about the pathophysiology that mediates the rapid ...
Boukli Nawal M, Shetty Vivekananda, Cubano Luis, Ricaurte Martha, Coelho-dos-Reis Jordana, Nickens Zacharie, Shah Punit, Talal Andrew H, Philip Ramila, Jain Pooja   +9 more
doaj   +1 more source

Members of the ran family of stress-inducible small GTP-binding proteins are differentially regulated in sweetpotato plants

Journal of Plant Biotechnology, 2013
Abstract Ran is a small GTP-binding protein that binds and subsequently hydrolyzes GTP. The functions of Ran in nuclear transport and mitotic progression are well conserved in plants and animals. In animal cells, stress treatments cause Ran relocalization and slowing of nuclear transport, but the role of Ran proteins in plant cells exposed to stress is
Young-Hwa Kim, Gyung Hye Huh
openaire   +2 more sources

Destabilization of Ran C-terminus promotes GTP loading and occurs in multiple Ran cancer mutations [PDF]

, 2018
Ran (Ras-related nuclear protein) plays several important roles in nucleo-cytoplasmic transport, mitotic spindle formation, nuclear envelope/nuclear pore complex assembly, and other diverse functions in the cytoplasm, as well as in cellular ...
Xiaofei Shen, Aiping Tong, Jinhan Zhou, Qiao Zhou, Xiaodong Sun, Qingxiang Sun, Yuqing Zhang, Yuping Tan, Da Jia   +8 more
core   +1 more source

Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity

Cells, 2019
DEAD-box helicase 3, X-linked (DDX3X) regulates the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR)-mediated antiviral response, but can also be a host factor contributing to the replication of viruses of significance to human health, such as ...
Steven M. Heaton, Sarah C. Atkinson, Melissa N. Sweeney, Sundy N. Y. Yang, David A. Jans, Natalie A. Borg   +5 more
doaj   +1 more source

Molecular Characterization and Functional Analysis of Annulate Lamellae Pore Complexes in Nuclear Transport in Mammalian Cells.

PLoS ONE, 2015
Annulate lamellae are cytoplasmic organelles containing stacked sheets of membranes embedded with pore complexes. These cytoplasmic pore complexes at annulate lamellae are morphologically similar to nuclear pore complexes at the nuclear envelope ...
Sarita Raghunayakula, Divya Subramonian, Mary Dasso, Rita Kumar, Xiang-Dong Zhang   +4 more
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source