Results 51 to 60 of about 13,129 (191)
Identification and functional characterization of the novel MAR-binding protein, SATB2 [PDF]
, 2004 The regulation of gene expression is governed in large part by transcription factors that bind to enhancers and promoters. The functions of transcription factors involve both the modulation of chromatin accessibility via the recruitment of histone ...
Dobreva, Gergana
core
Roles of Ran–GTP and Ran–GDP in precursor vesicle recruitment and fusion during nuclear envelope assembly in a human cell-free system [PDF]
, 2001 The molecular mechanism of nuclear envelope (NE) assembly is poorly understood, but in a cell-free system made from Xenopus eggs NE assembly is controlled by the small GTPase Ran [1,2]. In this system, Sepharose beads coated with Ran induce the formation
Zhang, CM +5 more
core +1 more source
Advanced Science, EarlyView.A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo +18 more
wiley +1 more source
Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response
Advanced Science, EarlyView.This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du +10 more
wiley +1 more source
In vivo analysis of the cellular functions of Ran binding protein 1 [PDF]
, 2020 Ph.D.The Ran-GTPase regulates multiple cellular processes, including nucleocytoplasmic transport, nuclear envelope (NE) assembly and mitotic spindle assembly.
core
The Conservation of Residues on the Surface of Ran GTPase [PDF]
, 2013 The conservation score is derived from Consurf–HSSP and is color-coded, with blue being most variable and red most conserved [42].(A,B) Front and back of the less-conserved interfaces between Ran GTPase and Ran-binding protein (RBP, gray) in Ran-binding ...
Wan Kyu Kim (14123) +3 more
core +1 more source
The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding
Animal Research and One Health, EarlyView.A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang +10 more
wiley +1 more source
Xpo1 and Ran[GTP] reduce but do not prevent ATP-dependent single-stranded RNA binding activity of Ded1. [PDF]
, 2015 (a) FAM-labeled 25mer RNA oligomers were incubated in the presence and absence of Ded1 variants (900 nM), Xpo1 (990 nM), and Ran[GTP]Q71L (1.17 μM), and resolved by native PAGE after addition of excess unlabeled RNA.
Gregory D. Bowman (762237) +1 more
core +1 more source
Cytoskeleton, EarlyView.ABSTRACT Microtubules play essential roles in numerous cellular processes. All microtubules are built from the protein tubulin, yet individual microtubules can differ spatially and temporally due to their tubulin isotype composition and post‐translational modifications (PTMs).
Ezekiel C. Thomas +5 more
wiley +1 more source
Cytoskeleton, EarlyView.ABSTRACT Microtubules are noncovalent polymers assembled from α/β tubulin dimers. Their structure, dynamics and interaction with effectors are regulated through the expression of diverse tubulin isotypes and chemically diverse posttranslational modifications, also known as the “tubulin code.” Understanding the biophysical correlates between tubulin ...
Jiayi Chen +2 more
wiley +1 more source