Results 61 to 70 of about 13,129 (191)

Novel Noninvasive Broad‐Spectrum Infrared Treatment of Ulcerative Colitis by Modulating T‐Cell Relocation

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
A novel graphene‐based broad‐spectrum infrared (BSIR) device is developed for the noninvasive treatment of ulcerative colitis (UC). BSIR irradiation effectively alleviates colonic inflammation and accelerates mucosal recovery by inducing the systemic relocation of T lymphocytes to the spleen.
Siyu Chen, Jiangtao Zhao, Bohan Jia, Zhigang Ren, Ranran Sun, Liwen Liu, Ding Zhang, Yanqiu Fu, Jia Yu, Shen Shen, Fujun Miao, Zaimei Huang, Ruixia Guo, Peng Zhang, Zujiang Yu, Guosheng Shao   +15 more
wiley   +1 more source

Nuclear transport factor p10/NTF2 functions as a Ran–GDP dissociation inhibitor (Ran-GDI) [PDF]

, 1998
The cytosolic nuclear transport factor p10/NTF2 is required for the translocation of karyophilic molecules through nuclear pores [1–3], and the small GTPase Ran is a key regulator of protein transport between the nucleus and cytoplasm [4,5].
Tachibana, Taro, Yoneda, Yoshihiro, Imamoto, Naoko, Yamada, Masami   +3 more
core   +1 more source

Generalizing the Gaussian Network Model: Spanning‐Tree Thermodynamics Shows Entropy‐Driven KRAS Activation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The GTPase KRAS executes a conformational switch between a GTP‐bound active state and a GDP‐bound inactive state, a process central to oncogenic signaling. However, the structural basis of this switching at the level of residue‐contact organization remains incompletely characterized by traditional binary structural models.
Fatma Senguler Ciftci, Burak Erman
wiley   +1 more source

Sodium Ions Affect GPR17 Conformational States and Functionality

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Sodium is an allosteric modulator of several class‐A GPCR regulating active versus inactive conformation state and may be a critical issue for the optimization of crystallization procedures. Herein, the role of Na+ in the regulation of GPR17 conformational states was studied through MD simulations of GPR17 wild‐type and mutated on two ...
Luca Palazzolo, Simona Daniele, Davide Bianchi, Lara Russo, Stefano Capaldi, Maria Letizia Trincavelli, Ivano Eberini   +6 more
wiley   +1 more source

The Cyst Nematode SPRYSEC Protein RBP-1 Elicits Gpa2- and RanGAP2-Dependent Plant Cell Death [PDF]

, 2009
Plant NB-LRR proteins confer robust protection against microbes and metazoan parasites by recognizing pathogen-derived avirulence (Avr) proteins that are delivered to the host cytoplasm.
Moffett, Peter, Alexandra Blanchard, Goverse Aska, Smant, G., Sacco, Melanie Ann, Koropacka, Kamila, Smant Geert, Peter Moffett, Grenier, E., Jaubert, Marianne J., Grenier, Eric, Goverse, A., Blanchard, A., Kamila Koropacka, Melanie Ann Sacco, Aska Goverse, Goverse, Aska, Moffett, P., Smant, Geert, Geert Smant, Koropacka, K.B., Blanchard, Alexandra, Moffett Peter, Jaubert Marianne J., Koropacka Kamila, Eric Grenier, Sacco, M.A., Sacco Melanie Ann, Marianne J Jaubert, Jaubert, M.J., Grenier Eric, Blanchard Alexandra   +31 more
core   +1 more source

Baicalein Sensitizes Radioresistant BT549 and MCF7‐R Breast Cancer Cells by Modulating Rac1 Signaling

Phytotherapy Research, EarlyView.
ABSTRACT Radioresistance remains a key barrier in breast cancer (BC) treatment. Baicalein, a flavonoid from Scutellaria baicalensis, has shown potential to enhance radiosensitivity. This study investigates its efficacy and mechanism in radioresistant BC models. Radioresistant BC cell models were established via fractionated irradiation and validated by
Zitong Zhao, Zhangyun Li, Quanzhou Peng, Shuqun Zhang   +3 more
wiley   +1 more source

RNA-dependent association with myosin IIA promotes F-actin-guided trafficking of the ELAV-like protein HuR to polysomes [PDF]

, 2013
The role of the mRNA-binding protein human antigen R (HuR) in stabilization and translation of AU-rich elements (ARE) containing mRNAs is well established.
Eberhardt, Wolfgang, Schulz, Sebastian, Pfeilschifter, Josef, Doller, Anke   +3 more
core   +1 more source

Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.

European journal of cell biology, 1996
A partial cDNA clone coding for the mouse homologue of the human Ran-GTP binding protein, RanBP2, has been isolated by screening of a murine expression library with antibodies to nup180, a previously identified nuclear pore complex protein (nucleoporin).
N, Wilken, J L, Senécal, U, Scheer, M C, Dabauvalle   +3 more
openaire   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

The NES of Ded1ΔC is critical for a Ran[GTP]-dependent interaction with Xpo1. [PDF]

, 2015
(a) The three protein components yield unique profiles by size exclusion chromatography. The profiles for each component applied individually on a Superdex 200 10/300 column are overlaid for comparison: Xpo1 (dark gray), Ded1ΔC (medium gray), and Ran[GTP]
Gregory D. Bowman (762237), Glenn Hauk (762236)   +1 more
core   +1 more source