Results 81 to 90 of about 11,277 (158)

Aging, Dauer, and Stature Phenotypes Are Conferred by Structure‐Directed Missense Mutations in the Endogenous AGE‐1/Phosphatidylinositol 3‐Kinase Catalytic Subunit

Aging Cell, Volume 25, Issue 6, June 2026.
Structure‐guided missense mutations in the C. elegans AGE‐1/PI3Kinase catalytic subunit and its LET‐60/Ras‐binding interface reveal separable signaling outputs from the Ras‐bound PI3K complex. Enhanced canonical catalytic activity, conferred by a gain‐of‐function mutation modeled on oncogenic human p110⍺ PI3K variants, promotes aging, reproductive ...
You Wu, Tam Duong, Neal R. Rasmussen, Kent L. Rossman, David J. Reiner   +4 more
wiley   +1 more source

GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling

British Journal of Pharmacology, Volume 183, Issue 11, Page 2619-2633, June 2026.
G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins.
Vsevolod V. Gurevich
wiley   +1 more source

A supramolecular assembly of cone‐specific G‐protein and cryptochrome 4a on lipid bilayer

The FEBS Journal, Volume 293, Issue 11, Page 3362-3375, June 2026.
Immobilized phospholipid bilayers on a sensor chip surface serve as membrane platform to investigate critical protein–lipid and protein–protein interaction processes by surface plasmon resonance. The putative magnetoreceptor cryptochrome 4a and the myristoylated cone‐specific G‐protein α‐subunit (Gtα) bind with high affinity to immobilized lipid ...
Ümmügülsüm Güzelsoy‐Flügge, Srđan Vujinović, Alexander Scholten, Karl‐Wilhelm Koch   +3 more
wiley   +1 more source

scRNA‐Seq reveals anti‐lymphoma immune responses in mogamulizumab‐associated skin eruptions

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 6, Page 1078-1090, June 2026.
CCR4 was expressed in malignant clones and regulatory T cells in untreated CTCL, that were decreased in MAR. Malignant clones in MAR showed a silenced phenotype with decreases in central memory markers SELL and CCR7, and GTP‐binding member GIMAP7 and upregulation of MMP2 inhibitor TIMP2 and tumour suppressor gene RUNX3.
Shannon Meledathu, Agata Kurowski, Malini P. Naidu, Jonas Adalsteinsson, Shane A. Meehan, Natalia Alkon, Lauren R. Port, Sumanth Chennareddy, Emry R. Cohenour, Grace Christensen, Jonah Shulman, Nicholas Gulati, Constanze Jonak, Patrick M. Brunner   +13 more
wiley   +1 more source

Allosteric inhibition of RAN decreases miR-126 biogenesis in endothelial cells and controls acute myeloid leukemia growth. [PDF]

Commun Biol
Valerio M, Wei W, Kang H, Ma N, Bhattacharya S, Baker G, Hu W, Zhang L, Hoang DH, Feng J, Zhang H, Zhang B, Perry JJP, Vaidehi N, Nguyen LXT, Marcucci G.   +15 more
europepmc   +1 more source

Induced opening of conformational switch I in GTP-bound Ran GTPase. [PDF]

Protein Sci
Czigleczki J, Dudas B, Balog E.
europepmc   +1 more source

Ran modulates allosteric crosstalk between importin β surfaces. [PDF]

Nat Commun
Ko YH, Li F, Suinn SS, Li J, Hou CD, Lokareddy RK, Cingolani G.   +6 more
europepmc   +1 more source

The eIF5-mimic protein 5MP1: a regulator of translation stringency and a multifaceted oncogene. [PDF]

J Biochem
Banerjee A, Brooke G, Ishiguro S, Asano K.   +3 more
europepmc   +1 more source

The role of phase separation for RNA and protein transport through the nuclear pore complex. [PDF]

J Exp Bot
Ejike JO, Davis GV, Restrepo-Escobar A, Dalal A, Nakamura M, Frommer WB, Schladt TM.   +6 more
europepmc   +1 more source

The Nuclear Transporter Transportin-3 Functions Under Oxidative Stress. [PDF]

Cells
Barling MAL, Thomas DR, Jans DA, Wagstaff KM.   +3 more
europepmc   +1 more source