Results 91 to 100 of about 13,129 (191)

Identification and Characterization of a Novel RanGTP-binding Protein in the Yeast Saccharomyces cerevisiae [PDF]

, 2003
International audienceThe small Ras-like GTPase Ran plays an essential role in the transport of macromolecules in and out of the nucleus and has been implicated in spindle (1,2 ) and nuclear envelope formation (3,4 ) during mitosis in higher eukaryotes ...
Gerstberger, Thomas, Künzler, Markus, Bischoff, F. Ralf, Legrain, Pierre, Fromont-Racine, Micheline, Braunwarth, Andreas, Hurt, Ed   +6 more
core   +1 more source

Expanding the Fish‐Brain Invitrome With the Senegalese Sole SsB‐1 Cell Line—A Versatile Model for Neurotropic Virus Research

Journal of Fish Diseases, EarlyView.
ABSTRACT Cell lines are essential tools for studying animal physiology and immunopathology, reducing the use of live animals and supporting the 3Rs principle of reduction, refinement, and replacement. The Senegalese sole (Solea senegalensis), a relevant species for Spanish aquaculture diversification, lacks established in vitro models. We developed SsB‐
Yulema Valero, Alberto Cuesta
wiley   +1 more source

Structural view of the Ran–Importin β interaction at 2.3 Å resolution [PDF]

, 1999
Transport receptors of the Importin β family shuttle between the nucleus and cytoplasm and mediate transport of macromolecules through nuclear pore complexes.
Wittinghofer, A., Arndt, A., Kutay, Ulrike, Görlich, Dirk, Kutay, U., Vetter, Ingrid R, Görlich, D., Vetter, I. R., Wittinghofer, Alfred, Vetter, I., Arndt, Andreas   +10 more
core   +1 more source

To Move or Not to Move: When and How Bacteria Suppress Flagellar Motility

Molecular Microbiology, EarlyView.
Motility cessation in bacteria is a key regulatory strategy that provides multiple survival advantages including enhanced community cooperation, niche adaptation and evasion of host immune responses. This process is controlled by associated mechanisms such as post‐translational modifications and second messenger signalling that stabilise non‐motile ...
Fatemeh Mohaghegh, Jacob Scadden, Matthew A. B. Baker   +2 more
wiley   +1 more source

RanGAP mediates GTP hydrolysis without an arginine finger [PDF]

, 2002
GTPase-activating proteins (GAPs) increase the rate of GTP hydrolysis on guanine nucleotide-binding proteins by many orders of magnitude. Studies with Ras and Rho have elucidated the mechanism of GAP action by showing that their catalytic machinery is ...
Wittinghofer, A., Körner, Carolin, Seewald, M., Alfred Wittinghofer, Vetter, Ingrid R., Carolin Körner, Seewald, Michael J., Körner, C., Wittinghofer, Alfred, Vetter, I., Ingrid R. Vetter, Michael J. Seewald   +11 more
core   +1 more source

A protein required for nuclear-protein import, Mog1p, directly interacts with GTP-Gsp1p, the Saccharomyces cerevisiae Ran homologue [PDF]

, 1998
We previously isolated 25 temperature-sensitive gsp1 alleles of Saccharomyces cerevisiae Ran homologue, each of which possesses amino acid changes that differ from each other.
OKI, Masaya, NISHIMOTO, Takeharu
core   +2 more sources

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

A T42A Ran Mutation: Differential Interactions with Effectors and Regulators, and Defect in Nuclear Protein Import [PDF]

, 2012
Ran, the small, predominantly nuclear GTPase, has been implicated in the regulation of a variety of cellular processes including cell cycle progression, nuclear-cytoplasmic trafficking of RNA and protein, nuclear structure, and DNA synthesis.
Drivas, George, Rush, Mark G., 1942-, Murphy, Gretchen A., Villamarin, Alicia, Moore, Mary Shannon, D'Eustachio, Peter, 1949-, Pérez de la Ossa, Pablo   +6 more
core  

A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly. [PDF]

, 2003
International audienceThe activated form of Ran (Ran-GTP) stimulates spindle assembly in Xenopus laevis egg extracts, presumably by releasing spindle assembly factors, such as TPX2 (target protein for Xenopus kinesin-like protein 2) and NuMA (nuclear ...
Tsai, Ming-Ying, Cao, Kan, Donovan, Peter, Ona Martin, Christiane Wiese, Ruderman, Joan, Martin, Ona, Ming-Ying Tsai, Yixian Zheng, Zheng, Yixian, Peter Donovan, Joan Ruderman, Wiese, Christiane, Claude Prigent, Prigent, Claude, Kan Cao   +15 more
core   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source