Results 111 to 120 of about 13,129 (191)

Memantine prevents acute stress‐induced memory deficits by reversing sex‐dependent pathophysiological glutamatergic alterations in the dorsal hippocampus

British Journal of Pharmacology, Volume 183, Issue 16, Page 4939-4952, August 2026.
Abstract Background and Purpose The neural mechanisms underlying effects of acute stress on memory are poorly understood. We demonstrated previously that acute stress produces identical spatial memory deficits in male and female mice but through distinct molecular mechanisms, with females exhibiting up‐regulation of N‐methyl‐D‐aspartate (NMDA) receptor
Sebastiano A. Torrisi, Lidia Diolosà, Giuseppe Aceto, Claudia Marchetti, Federica Geraci, Konstantinos Partsinevelos, Silvia Rizzo, Margherita Grasso, Filippo Caraci, Francesco Bellia, Giovanni Li Volti, Angela Maria Amorini, Marcello D′Ascenzo, Gian Marco Leggio   +13 more
wiley   +1 more source

Shared and specific molecular mechanisms of proteasome inhibitors in chemotherapy‐induced peripheral neurotoxicity

British Journal of Pharmacology, Volume 183, Issue 16, Page 5120-5147, August 2026.
This study compares the molecular mechanisms of chemotherapy‐related peripheral neurotoxicity of two proteasome inhibitors, bortezomib and carfilzomib, using a multidisciplinary approach to reveal that, alongside shared effects on mitochondria structure and function, the more neurotoxic drug BTZ has specific effects on microtubules and mitochondrial ...
Federico Iseppon, Alessio Malacrida, Alessia Chiorazzi, Annalisa Canta, Paola Alberti, Valentina Alda Carozzi, Eleonora Pozzi, Virginia Rodriguez‐Menendez, Laura Cherchi, Valentina Fabbro, Lisa Pagani, Elisa Tonelli, Laura Tapella, Andrea Mattarei, Sara Palermo, Daniele Cartelli, Mario Mauri, Noemi Scimia, Serena Stanga, Dmitry Lim, Carla Distasi, Marta Delconti, Clizia Chinello, Patricia Morcillo, Maria Elena Pero, Francesca Bartolini, Guido Cavaletti, Cristina Meregalli   +27 more
wiley   +1 more source

Honeydew: A Fluorescent Aptamer for Low‐Cost Azo Food Dyes

ChemBioChem, Volume 27, Issue 14, 29 July 2026.
Light‐up RNA aptamers that bind nonfluorescent dyes and conditionally activate their fluorescence are powerful tools for RNA imaging and biomolecular sensing. A barrier to widespread adoption of this technology is a reliance on bespoke dyes prepared by labor‐intensive or costly custom synthesis.
Joseph M. Heili, Paul H. Mroch, Tanner G. Hoog, Orion M. Venero, Grace M. Gustafson, Katarzyna P. Adamala, Aaron E. Engelhart   +6 more
wiley   +1 more source

Ran-binding protein 5 (RanBP5) is related to the nuclear transport factor importin-beta but interacts differently with RanBP1. [PDF]

, 1997
We report the identification and characterization of a novel 124-kDa Ran binding protein, RanBP5. This protein is related to importin-beta, the key mediator of nuclear localization signal (NLS)-dependent nuclear transport.
Prehn, S., Ponstingl, H., Bischoff, F., Schäfer, W., Görlich, D., Zimmermann, H., Deane, R., Mueller, L.   +7 more
core   +1 more source

Expression of the Xenopus GTP-binding protein gene Ran during embryogenesis

Expression of the Xenopus GTP-binding protein gene Ran during embryogenesis
The Ran gene family encodes small GTP binding proteins that are associated with a variety of nuclear processes. We isolated a Xenopus Ran cDNA and analyzed the pattern of expression of this gene during embryogenesis. Ran is expressed maternally and later in the CNS, neural crest, mesenchyme, eyes, and otic vesicles.
openaire  

Characterization of Rah, a low molecular weight GTP -binding protein [PDF]

, 2001
Low molecular weight GTP binding proteins, better known as small GTPases, are a large superfamily of proteins which control diverse cellular events including cell growth, transformation, cytoskeletal Changes, vesicular trafficking, and nuclear transport.
Hari, Malathi
core  

Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts [PDF]

, 1999
Ran is an abundant GTPase of the Ras superfamily that is highly conserved in eukaryotes, In interphase cells, Ran is mainly nuclear and thought to be predominantly GTP-bound, but it is also present in the cytoplasm, probably GDP-bound, This asymmetric ...
Zhang, CM, Clarke, PR, Hughes, Mike, Hughes, M, Clarke, Paul R., Zhang, Chuanmao   +5 more
core  

The Interaction of Early Salt Stress-Induced 2 (ESI2) and the Ran G Protein in Arabidopsis [PDF]

, 2013
The Early Salt Stress-Induced 2 protein, ESI2, was identified as an interacting protein with the GTP-binding protein RAN via a His6-tag pull-down assay and by bimolecular fluorescent complementation.
Ralevski, Alexandra
core  

Allosteric inhibition of RAN decreases miR-126 biogenesis in endothelial cells and controls acute myeloid leukemia growth. [PDF]

Commun Biol
Valerio M, Wei W, Kang H, Ma N, Bhattacharya S, Baker G, Hu W, Zhang L, Hoang DH, Feng J, Zhang H, Zhang B, Perry JJP, Vaidehi N, Nguyen LXT, Marcucci G.   +15 more
europepmc   +1 more source

Induced opening of conformational switch I in GTP-bound Ran GTPase. [PDF]

Protein Sci
Czigleczki J, Dudas B, Balog E.
europepmc   +1 more source