Results 21 to 30 of about 4,434,687 (184)

14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins [PDF]

, 2013
Signaling through G proteins normally involves conformational switching between GTP- and GDP-bound states. Several Rho GTPases are also regulated by RhoGDI binding and sequestering in the cytosol.
Riou, P, Parker, Peter J., O’Reilly, N., George, Roger, Ritu Garg, McColl, Brad, Ganka Bineva, Kjær, S., Svend Kjær, Garg, R, Bineva, G., Thompson, AJ, Reymond, N, Thompson, Andrew J., Philippe Riou, Purkiss, Andrew, Nicola O’Reilly, Parker, Peter J, Brad McColl, Peter J. Parker, Neil Q. McDonald, Parker, Peter J.; id_orcid, O’Reilly, Nicola, Riou, P., Purkiss, A, Parker, PJ, Thompson, A.J., McColl, B, Cain, RJ, Parker, P.J., Kjær, Svend, McColl, B., Andrew Purkiss, O’Reilly, N, Kjær, S, Garg, R., Garg, Ritu, O'Reilly, Nicola, Anne J. Ridley, Cain, Robert J, Robert J. Cain, McDonald, Neil Q, Ridley, Anne J, Bineva, G, Ridley, A.J., Purkiss, Andrew G., Nicolas Reymond, George, R., Thompson, Andrew J, Reymond, N., Reymond, Nicolas, Cain, Robert J., Bineva, Ganka, McDonald, NQ, Riou, Philippe, Andrew J. Thompson, Ridley, AJ, Kjaer, Svend, George, R, Cain, R.J., Ridley, Anne J., Roger George, McDonald, Neil Q.   +62 more
core   +1 more source

The importin beta superfamily member RanBP17 exhibits a role in cell proliferation and is associated with improved survival of patients with HPV+ HNSCC

BMC Cancer, 2022
Background More than twenty years after its discovery, the role of the importin beta superfamily member Ran GTP-binding protein (RanBP) 17 is still ill defined.
Robert Mandic, André Marquardt, Philip Terhorst, Uzma Ali, Annette Nowak-Rossmann, Chengzhong Cai, Fiona R. Rodepeter, Thorsten Stiewe, Bernadette Wezorke, Michael Wanzel, Andreas Neff, Boris A. Stuck, Michael Bette   +12 more
doaj   +1 more source

The pH dependence of polymerization and bundling by the essential bacterial cytoskeltal protein FtsZ [PDF]

, 2011
There is a growing body of evidence that bacterial cell division is an intricate coordinated process of comparable complexity to that seen in eukaryotic cells.
Raúl Pacheco-Gómez, Rodger, A, Roper, DI, Rodger, Alison, Timothy R Dafforn, Dafforn, Tim, David I. Roper, Pacheco-Gómez, Raúl, Pacheco-Gómez Raúl, Alison Rodger, Dafforn Timothy R., Roper, David I., Pacheco-Gomez, R, Dafforn, Timothy, Rodger Alison, David I Roper, Roper David I., Timothy R. Dafforn   +17 more
core   +2 more sources

Induction of Ran GTP drives ciliogenesis [PDF]

, 2011
The small GTPase Ran and the importin proteins regulate nucleocytoplasmic transport. New evidence suggests that Ran GTP and the importins are also involved in conveying proteins into cilia.
Martens, Jeffrey R, Sajjan, Uma, Ben Margolis, Margolis, Ben, Shuling Fan, Verhey, Kristen J, Toby W. Hurd, Dishinger, John F, Kristen J. Verhey, Jeffrey R. Martens, Hurd, Toby W, Chia Jen Liu, Eileen L. Whiteman, Uma Sajjan, Whiteman, Eileen L, Liu, Chia Jen, Fan, Shuling, McIntyre, Jeremy C, Jeremy C. McIntyre, John F. Dishinger   +19 more
core   +1 more source

Guanosine nucleotides regulate B2 kinin receptor affinity of agonists but not of antagonists: Discussion of a model proposing receptor precoupling to G protein [PDF]

, 2000
The effect of nucleotides on binding of the B2 kinin (BK) receptor agonist {[}H-3]BK and the antagonist {[}H-3]NPC17731 to particulate fractions of human foreskin fibroblasts was studied.
Er Faussner, Faussner, Alexander, Adelbert A. Roscher, Roscher, Adelbert A.   +3 more
core   +1 more source

Inter-cellular transport of ran GTPase.

PLoS ONE, 2015
Ran, a member of the Ras-GTPase superfamily, has a well-established role in regulating the transport of macromolecules across the nuclear envelope (NE). Ran has also been implicated in mitosis, cell cycle progression, and NE formation. Over-expression of
Deepak Khuperkar, Mary Helen, Indrasen Magre, Jomon Joseph   +3 more
doaj   +1 more source

Identification of alternatively spliced MsRan transcripts involved in low temperature response in Musa spp.

Biologia Plantarum, 2017
Ran is involved in response to external stimuli. In this study, six MsRan gene cDNA sequences were isolated from wild banana (Musa spp. AB group) from Sanming City, China.
Y. L. Zhang, Z. Z. Fang, Z. X. Lai
doaj   +1 more source

The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells

BMC Cell Biology, 2010
Background Regulator of chromosome condensation 1 (RCC1) is the guanine nucleotide exchange factor for Ran GTPase. Localised generation of Ran-GTP by RCC1 on chromatin is critical for nucleocytoplasmic transport, mitotic spindle assembly and nuclear ...
Sanderson Helen S, Hood Fiona E, Hitakomate Ekarat, Clarke Paul R   +3 more
doaj   +1 more source

In Preclinical Model of Ovarian Cancer, the SGK1 Inhibitor SI113 Counteracts the Development of Paclitaxel Resistance and Restores Drug Sensitivity

Translational Oncology, 2019
Ovarian cancer is the second most common gynecological malignancy worldwide. Paclitaxel is particularly important in the therapy of ovarian carcinomas, but the treatment efficacy is counteracted by the development of resistance to chemotherapy.
Lucia D'Antona, Vincenzo Dattilo, Giada Catalogna, Domenica Scumaci, Claudia Vincenza Fiumara, Francesca Musumeci, Giuseppe Perrotti, Silvia Schenone, Rossana Tallerico, Cristina B. Spoleti, Nicola Costa, Rodolfo Iuliano, Giovanni Cuda, Rosario Amato, Nicola Perrotti   +14 more
doaj   +1 more source

Characterisation of Bombyx mori odorant-binding proteins reveals that a general odorant-binding protein discriminates between sex pheromone components [PDF]

, 2009
In many insect species, odorant-binding proteins (OBPs) are thought to be responsible for the transport of pheromones and other semiochemicals across the sensillum lymph to the olfactory receptors (ORs) within the antennal sensilla.
Field, L.M., Pickett, J. A., Dufour, S. G. L., Zhou, J.J., Keep, N. H., Dufour, Samuel, Field, Linda M., He, X., Hooper, A.M., Hooper, A. M., Pickett, John A., Pickett, J.A., He, Xiaoli, Dufour, S., Field, L. M., Keep, Nicholas H., Robertson, G., Robertson, Giles, Zhou, J-J., Hooper, Antony M., Zhou, Jing-Jiang   +20 more
core   +1 more source