Results 21 to 30 of about 13,129 (191)

The RanGTP pathway: from nucleo-cytoplasmic transport to spindle assembly and beyond

Frontiers in Cell and Developmental Biology, 2016
The small GTPase Ran regulates the interaction of transport receptors with a number of cellular cargo proteins. The high affinity binding of the GTP-bound form of Ran to import receptors promotes cargo release, whereas its binding to export receptors ...
Tommaso eCavazza, Tommaso eCavazza, Isabelle eVernos, Isabelle eVernos, Isabelle eVernos   +4 more
doaj   +1 more source

Topological and functional properties of the small GTPases protein interaction network. [PDF]

PLoS ONE, 2012
Small GTP binding proteins of the Ras superfamily (Ras, Rho, Rab, Arf, and Ran) regulate key cellular processes such as signal transduction, cell proliferation, cell motility, and vesicle transport.
Anna Delprato
doaj   +1 more source

The importin beta superfamily member RanBP17 exhibits a role in cell proliferation and is associated with improved survival of patients with HPV+ HNSCC

BMC Cancer, 2022
Background More than twenty years after its discovery, the role of the importin beta superfamily member Ran GTP-binding protein (RanBP) 17 is still ill defined.
Robert Mandic, André Marquardt, Philip Terhorst, Uzma Ali, Annette Nowak-Rossmann, Chengzhong Cai, Fiona R. Rodepeter, Thorsten Stiewe, Bernadette Wezorke, Michael Wanzel, Andreas Neff, Boris A. Stuck, Michael Bette   +12 more
doaj   +1 more source

RANBP2 (RAN binding protein) [PDF]

, 2003
Review on RANBP2 (RAN binding protein), with data on DNA, on the protein encoded, and where the gene is ...
Huret, JL, Senon, S
core   +1 more source

Inter-cellular transport of ran GTPase.

PLoS ONE, 2015
Ran, a member of the Ras-GTPase superfamily, has a well-established role in regulating the transport of macromolecules across the nuclear envelope (NE). Ran has also been implicated in mitosis, cell cycle progression, and NE formation. Over-expression of
Deepak Khuperkar, Mary Helen, Indrasen Magre, Jomon Joseph   +3 more
doaj   +1 more source

Identification of alternatively spliced MsRan transcripts involved in low temperature response in Musa spp.

Biologia Plantarum, 2017
Ran is involved in response to external stimuli. In this study, six MsRan gene cDNA sequences were isolated from wild banana (Musa spp. AB group) from Sanming City, China.
Y. L. Zhang, Z. Z. Fang, Z. X. Lai
doaj   +1 more source

Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities [PDF]

, 1996
The small nuclear GTP binding protein Ran is required for transport of nuclear proteins through the nuclear pore complex (NPC). Although it is known that GTP hydrolysis by Ran is essential for this reaction, it has been unclear whether additional energy ...
Dingwall, Colin, Weis, Karsten, Lamond, Angus I.; id_orcid   +2 more
core   +1 more source

Kap-Centric control of nuclear pores based on promiscuous binding to FG nucleoporins [PDF]

, 2014
Nuclear pore complexes (NPCs) are remarkable molecular machines that perforate the nuclear envelope (NE) in eukaryotic cells and mediate the rapid bidirectional traffic of hundreds of proteins, ribonucleoproteins, and metabolites across the nuclear ...
Wagner, Raphael S.
core   +1 more source

The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells

BMC Cell Biology, 2010
Background Regulator of chromosome condensation 1 (RCC1) is the guanine nucleotide exchange factor for Ran GTPase. Localised generation of Ran-GTP by RCC1 on chromatin is critical for nucleocytoplasmic transport, mitotic spindle assembly and nuclear ...
Sanderson Helen S, Hood Fiona E, Hitakomate Ekarat, Clarke Paul R   +3 more
doaj   +1 more source

The Ran-GTP Gradient Spatially Regulates XCTK2 in the Spindle [PDF]

, 2015
SummaryRan is a small GTP binding protein that was originally identified as a regulator of nucleocytoplasmic transport [1] and subsequently found to be important for spindle formation [2–5].
Weaver, Lesley N., Shaw, Sidney L., Ems-McClung, Stephanie C., Yang, Ge, Chen, Sez-Hon R., Walczak, Claire E.   +5 more
core   +1 more source