Ran GTPase: A Key Player in Tumor Progression and Metastasis
Frontiers in Cell and Developmental Biology, 2020 Ran (Ras-related nuclear protein) GTPase is a member of the Ras superfamily. Like all the GTPases, Ran cycles between an active (GTP-bound) and inactive (GDP-bound) state.
Zied Boudhraa +9 more
doaj +1 more source
A new survivin tracer tracks, delocalizes and captures endogenous survivin at different subcellular locations and in distinct organelles [PDF]
, 2016 Survivin, the smallest member of the inhibitor of apoptosis protein family, plays a central role during mitosis and exerts a cytoprotective function. Survivin is highly expressed in most cancer types and contributes to multiple facets of carcinogenesis ...
Beghein, Els +5 more
core +2 more sources
The key role of microtubules in hypoxia preconditioning-induced nuclear translocation of HIF-1α in rat cardiomyocytes [PDF]
PeerJ, 2017 Background Hypoxia-inducible factor (HIF)-1 is involved in the regulation of hypoxic preconditioning in cardiomyocytes. Under hypoxic conditions, HIF-1α accumulates and is translocated to the nucleus, where it forms an active complex with HIF-1β and ...
Hai Guo +5 more
doaj +2 more sources
Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus [PDF]
, 2004 The tumor suppressor protein p53 is known to be transported to the nucleus along microtubular tracks by cytoplasmic dynein. However, the connection between p53 and the dynein motor protein complex has not been established.
Galigniana, Mario Daniel +4 more
core +1 more source
Size-dependent steady state saturation limit in biomolecular transport through nuclear membranes.
PLoS ONEThe nucleus preserves the genomic DNA of eukaryotic organisms and maintains the integrity of the cell by regulating the transport of molecules across the nuclear membrane.
P K Shakhi +5 more
doaj +1 more source
"Alternative" endocytic mechanisms exploited by pathogens: new avenues for therapeutic delivery? [PDF]
, 2007 Some pathogens utilize unique routes to enter cells that may evade the intracellular barriers encountered by the typical clathrin-mediated endocytic pathway.
Medina-Kauwe, LK
core +1 more source
Protoparvovirus Knocking at the Nuclear Door
Viruses, 2017 Protoparvoviruses target the nucleus due to their dependence on the cellular reproduction machinery during the replication and expression of their single-stranded DNA genome.
Elina Mäntylä +2 more
doaj +1 more source
Nanoscale protein diffusion by STED-based pair correlation analysis. [PDF]
PLoS ONE, 2014 We describe for the first time the combination between cross-pair correlation function analysis (pair correlation analysis or pCF) and stimulated emission depletion (STED) to obtain diffusion maps at spatial resolution below the optical diffraction limit
Paolo Bianchini +4 more
doaj +1 more source
Petal Senescence: New Concepts for Ageing Cells [PDF]
, 2009 Senescence in flower petals can be regarded as a form of programmed cell death (PCD), being a process where cells or tissues are broken down in an orderly and predictable manner, whereby nutrients are re-used by other cells, tissues or plant parts.
Doorn, W.G., van, Woltering, E.J.
core +3 more sources
Attenuation of transcriptional bursting in mRNA transport
, 2009 Due to the stochastic nature of biochemical processes, the copy number of any given type of molecule inside a living cell often exhibits large temporal fluctuations.
Izaurralde E +4 more
core +1 more source