Nucleocytoplasmic distribution and dynamics of the autophagosome marker EGFP-LC3. [PDF]
PLoS ONE, 2010 The process of autophagy involves the formation of autophagosomes, double-membrane structures that encapsulate cytosol. Microtubule-associated protein light chain 3 (LC3) was the first protein shown to specifically label autophagosomal membranes in ...
Kimberly R Drake +2 more
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Cells, 2020 Background: The central channel of the nuclear pore complex plays an important role in the selective transport of proteins between the nucleus and cytoplasm.
Ryotaro Okazaki +2 more
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Identification and characterization of the regions involved in the nuclear translocation of the heterodimeric leishmanial DNA topoisomerase IB. [PDF]
PLoS ONE, 2013 Leishmania donovani, the causative organism for visceral leishmaniasis, contains a unique heterodimeric DNA-topoisomerase IB (LdTopIB). LdTopIB is a heterodimer made up of a large subunit and a small subunit that must interact with each other to build an
Christopher F Prada +5 more
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Intracellular Localization of Blattella germanica Densovirus (BgDV1) Capsid Proteins
Viruses, 2018 Densovirus genome replication and capsid assembly take place in the nucleus of the infected cells. However, the mechanisms underlying such processes as the delivery of virus proteins to the nucleus and the export of progeny virus from the nucleus remain ...
Evgeny N. Kozlov +4 more
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Mapping eGFP oligomer mobility in living cell nuclei. [PDF]
PLoS ONE, 2009 Movement of particles in cell nuclei can be affected by viscosity, directed flows, active transport, or the presence of obstacles such as the chromatin network.
Nicolas Dross +5 more
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Axonal T3 uptake and transport can trigger thyroid hormone signaling in the brain
eLife, 2023 The development of the brain, as well as mood and cognitive functions, are affected by thyroid hormone (TH) signaling. Neurons are the critical cellular target for TH action, with T3 regulating the expression of important neuronal gene sets. However, the
Federico Salas-Lucia +7 more
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Yeast karyopherin Kap95 is required for cell cycle progression at Start
BMC Cell Biology, 2010 Background The control of the subcellular localization of cell cycle regulators has emerged as a crucial mechanism in cell division regulation. The active transport of proteins between the nucleus and the cytoplasm is mediated by the transport receptors ...
Igual Juan, Taberner Francisco
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PLoS ONE, 2011 Background9b is an accessory protein of the SARS-CoV. It is a small protein of 98 amino acids and its structure has been solved recently. 9b is known to localize in the extra-nuclear region and has been postulated to possess a nuclear export signal (NES),
Kulbhushan Sharma +9 more
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Novel Anthra[1,2-c][1,2,5]Thiadiazole-6,11-Diones as Promising Anticancer Lead Compounds: Biological Evaluation, Characterization & Molecular Targets Determination. [PDF]
PLoS ONE, 2016 The novel compounds NSC745885 and NSC757963 developed at our laboratory were tested against a panel of 60 cancer cell lines at the National Cancer Institute, USA, and a panel of 39 cancer cell lines at the Japanese Foundation of Cancer Research.
Ahmed Atef Ahmed Ali +7 more
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Nuclear Herpesvirus Capsid Motility Is Not Dependent on F-Actin
mBio, 2014 A considerable part of the herpesvirus life cycle takes place in the host nucleus. While much progress has been made to understand the molecular processes required for virus replication in the nucleus, much less is known about the temporal and spatial ...
Jens B. Bosse +7 more
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