Results 31 to 40 of about 9,999,055 (259)

Thermodynamic pathways to genome spatial organization in the cell nucleus [PDF]

, 2009
The architecture of the eukaryotic genome is characterized by a high degree of spatial organization. Chromosomes occupy preferred territories correlated to their state of activity and, yet, displace their genes to interact with remote sites in complex ...
A. Prisco, Prisco, Antonella, Nicodemi, Mario   +2 more
core   +1 more source

Pigment epithelium-derived factor (PEDF) interacts with transportin SR2, and active nuclear import is facilitated by a novel nuclear localization motif.

PLoS ONE, 2011
PEDF (Pigment epithelium-derived factor) is a non-inhibitory member of the serpin gene family (serpinF1) that displays neurotrophic and anti-angiogenic properties.
Sergio Anguissola, William J McCormack, Michelle A Morrin, Wayne J Higgins, Denise M Fox, D Margaret Worrall   +5 more
doaj   +1 more source

Ran GTPase: A Key Player in Tumor Progression and Metastasis

Frontiers in Cell and Developmental Biology, 2020
Ran (Ras-related nuclear protein) GTPase is a member of the Ras superfamily. Like all the GTPases, Ran cycles between an active (GTP-bound) and inactive (GDP-bound) state.
Zied Boudhraa, Zied Boudhraa, Euridice Carmona, Euridice Carmona, Diane Provencher, Diane Provencher, Diane Provencher, Anne-Marie Mes-Masson, Anne-Marie Mes-Masson, Anne-Marie Mes-Masson   +9 more
doaj   +1 more source

Defining the subcellular interface of nanoparticles by live-cell imaging. [PDF]

PLoS ONE, 2013
Understanding of nanoparticle-bio-interactions within living cells requires knowledge about the dynamic behavior of nanomaterials during their cellular uptake, intracellular traffic and mutual reactions with cell organelles. Here, we introduce a protocol
Peter H Hemmerich, Anna H von Mikecz
doaj   +1 more source

Nucleocytoplasmic shuttling activity of ataxin-3. [PDF]

PLoS ONE, 2009
Spinocerebellar ataxia type-3, also known as Machado-Joseph Disease (MJD), is one of many inherited neurodegenerative disorders caused by polyglutamine-encoding CAG repeat expansions in otherwise unrelated genes.
Sandra Macedo-Ribeiro, Luísa Cortes, Patrícia Maciel, Ana Luísa Carvalho   +3 more
doaj   +1 more source

Lactobacillus salivarius Promotion of Intestinal Stem Cell Activity in Hens Is Associated with Succinate-Induced Mitochondrial Energy Metabolism

mSystems, 2022
Currently, the regulation of Lactobacillus on intestinal stem cells (ISCs) attracts broad attention, but their active ingredients and the underlying mechanism are worthy of further study.
Zhou Zhou, Lingzi Yu, Jiajia Cao, Jiaming Yu, Zhibo Lin, Yi Hong, Sibo Jiang, Cong Chen, Yuling Mi, Caiqiao Zhang, Jian Li   +10 more
doaj   +1 more source

Characterization of Ku70(2)-NLS as bipartite nuclear localization sequence for non-viral gene delivery. [PDF]

, 2012
Several barriers have to be overcome in order to achieve gene expression in target cells, e.g. cellular uptake, endosomal release and translocation to the nucleus.
Maucksch, Christof, Mittal, Rashmi, Rudolph, Carsten, Rashmi Mittal, Mittal Rashmi, Christof Maucksch, Alexander Bohla, Maucksch Christof, Carsten Rudolph, Joseph Rosenecker, Bohla, Alexander, Matschke, Johannes, Rosenecker Joseph, Bohla Alexander, Matschke Johannes, Rosenecker, Joseph, Rudolph Carsten, Johannes Matschke   +17 more
core   +2 more sources

Size-dependent steady state saturation limit in biomolecular transport through nuclear membranes.

PLoS ONE
The nucleus preserves the genomic DNA of eukaryotic organisms and maintains the integrity of the cell by regulating the transport of molecules across the nuclear membrane.
P K Shakhi, M M Bijeesh, J Hareesh, Toby Joseph, P Nandakumar, Geetha K Varier   +5 more
doaj   +1 more source

The key role of microtubules in hypoxia preconditioning-induced nuclear translocation of HIF-1α in rat cardiomyocytes [PDF]

PeerJ, 2017
Background Hypoxia-inducible factor (HIF)-1 is involved in the regulation of hypoxic preconditioning in cardiomyocytes. Under hypoxic conditions, HIF-1α accumulates and is translocated to the nucleus, where it forms an active complex with HIF-1β and ...
Hai Guo, Hong Zheng, Jianjiang Wu, Hai-ping Ma, Jin Yu, Maimaitili Yiliyaer   +5 more
doaj   +2 more sources

tRNAs promote nuclear import of HIV-1 intracellular reverse transcription complexes [PDF]

, 2006
Infection of non-dividing cells is a biological property of HIV-1 crucial for virus transmission and AIDS pathogenesis. This property depends on nuclear import of the intracellular reverse transcription and pre-integration complexes (RTCs/PICs).
Zaitseva Lyubov, Fassati Ariberto, Myers Richard, Myers, R, Lyubov Zaitseva, Ariberto Fassati, Fassati, A, Richard Myers, Zaitseva, L   +8 more
core   +1 more source