Results 31 to 40 of about 329,821 (263)

Yeast karyopherin Kap95 is required for cell cycle progression at Start

BMC Cell Biology, 2010
Background The control of the subcellular localization of cell cycle regulators has emerged as a crucial mechanism in cell division regulation. The active transport of proteins between the nucleus and the cytoplasm is mediated by the transport receptors ...
Igual Juan, Taberner Francisco
doaj   +1 more source

The role of spatial averaging in the precision of gene expression patterns [PDF]

, 2009
During embryonic development, differentiating cells respond via gene expression to positional cues from morphogen gradients. While gene expression is often highly erratic, embryonic development is precise. We show by theory and simulations that diffusion
Erdmann, Thorsten, Howard, Martin, Wolde, Pieter Rein ten   +2 more
core   +3 more sources

SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus.

PLoS ONE, 2011
Background9b is an accessory protein of the SARS-CoV. It is a small protein of 98 amino acids and its structure has been solved recently. 9b is known to localize in the extra-nuclear region and has been postulated to possess a nuclear export signal (NES),
Kulbhushan Sharma, Sara Åkerström, Anuj Kumar Sharma, Vincent T K Chow, Shumein Teow, Bernard Abrenica, Stephanie A Booth, Timothy F Booth, Ali Mirazimi, Sunil K Lal   +9 more
doaj   +1 more source

Novel Anthra[1,2-c][1,2,5]Thiadiazole-6,11-Diones as Promising Anticancer Lead Compounds: Biological Evaluation, Characterization & Molecular Targets Determination. [PDF]

PLoS ONE, 2016
The novel compounds NSC745885 and NSC757963 developed at our laboratory were tested against a panel of 60 cancer cell lines at the National Cancer Institute, USA, and a panel of 39 cancer cell lines at the Japanese Foundation of Cancer Research.
Ahmed Atef Ahmed Ali, Yu-Ru Lee, Tsung-Chih Chen, Chun-Liang Chen, Chia-Chung Lee, Chia-Yang Shiau, Chiao-Hsi Chiang, Hsu-Shan Huang   +7 more
doaj   +1 more source

Nuclear Herpesvirus Capsid Motility Is Not Dependent on F-Actin

mBio, 2014
A considerable part of the herpesvirus life cycle takes place in the host nucleus. While much progress has been made to understand the molecular processes required for virus replication in the nucleus, much less is known about the temporal and spatial ...
Jens B. Bosse, Stina Virding, Stephan Y. Thiberge, Julian Scherer, Harald Wodrich, Zsolt Ruzsics, Ulrich H. Koszinowski, Lynn W. Enquist   +7 more
doaj   +1 more source

Defining the subcellular interface of nanoparticles by live-cell imaging. [PDF]

PLoS ONE, 2013
Understanding of nanoparticle-bio-interactions within living cells requires knowledge about the dynamic behavior of nanomaterials during their cellular uptake, intracellular traffic and mutual reactions with cell organelles. Here, we introduce a protocol
Peter H Hemmerich, Anna H von Mikecz
doaj   +1 more source

Dye- and fluorescence-based assay to characterize symplastic and apoplastic trafficking in soybean (Glycime max L.) endosperm

Botanical Studies, 2019
Background Endosperm is a triploid tissue in seed resulting from a sperm nucleus fused with the binucleate central cell after double fertilization. Endosperm may be involved in metabolite production, solute transport, nutrient storage, and germination ...
Ming-Der Shih, Jian-Shin Lin, Mei-Jane Fang, Yuan-Ching Tsai, Yue-Ie C. Hsing   +4 more
doaj   +1 more source

Nucleocytoplasmic shuttling activity of ataxin-3. [PDF]

PLoS ONE, 2009
Spinocerebellar ataxia type-3, also known as Machado-Joseph Disease (MJD), is one of many inherited neurodegenerative disorders caused by polyglutamine-encoding CAG repeat expansions in otherwise unrelated genes.
Sandra Macedo-Ribeiro, Luísa Cortes, Patrícia Maciel, Ana Luísa Carvalho   +3 more
doaj   +1 more source

Lactobacillus salivarius Promotion of Intestinal Stem Cell Activity in Hens Is Associated with Succinate-Induced Mitochondrial Energy Metabolism

mSystems, 2022
Currently, the regulation of Lactobacillus on intestinal stem cells (ISCs) attracts broad attention, but their active ingredients and the underlying mechanism are worthy of further study.
Zhou Zhou, Lingzi Yu, Jiajia Cao, Jiaming Yu, Zhibo Lin, Yi Hong, Sibo Jiang, Cong Chen, Yuling Mi, Caiqiao Zhang, Jian Li   +10 more
doaj   +1 more source

Pigment epithelium-derived factor (PEDF) interacts with transportin SR2, and active nuclear import is facilitated by a novel nuclear localization motif.

PLoS ONE, 2011
PEDF (Pigment epithelium-derived factor) is a non-inhibitory member of the serpin gene family (serpinF1) that displays neurotrophic and anti-angiogenic properties.
Sergio Anguissola, William J McCormack, Michelle A Morrin, Wayne J Higgins, Denise M Fox, D Margaret Worrall   +5 more
doaj   +1 more source