Results 41 to 50 of about 315,054 (297)

Regulation of Stat3 nuclear export [PDF]

Journal of Clinical Investigation, 2003
Stat3 is the most pleiotropic member of the signal transducer and activator of transcription (STAT) family of transcription factors and mediates pivotal responses for the cytokine family. In resting cells, STATs, including Stat3, reside largely in the cytoplasm.
Samita, Bhattacharya, Christian, Schindler   +1 more
openaire   +2 more sources

Targeting nuclear transporters in cancer: Diagnostic, prognostic and therapeutic potential [PDF]

, 2016
The Karyopherin superfamily is a major class of soluble transport receptors consisting of both import and export proteins. The trafficking of proteins involved in transcription, cell signalling and cell cycle regulation among other functions across the ...
Aggarwal, Albee, Alnabulsi, Alshareeda, Altan, Angus, Behrens, Bernis, Blower, Brinkmann, Brinkmann, Cansizoglu, Chang, Christiansen, Dahl, Das, Dasso, Depping, Dikovskaya, Forbes, Gluz, Gontan, Gorlich, Gousias, Gousias, Gousias, Grupp, Gruss, Hashimoto, Hintersteiner, Hu, Huang, Huang, Huang, Hutchins, Hügel, Ishizawa, Jensen, Jiang, Kahle, Kau, Kazim, Kim, Kimura, King, Knauer, Kojima, Kosugi, Kudo, Kurisaki, Kutay, Kuusisto, Kuusisto, Lapalombella, Latvia, Lau, Laurila, Li, Liang, Liao, Lin, Lin, Lorenzato, Ma, Marfori, Martens-de Kemp, Melo, Mortezavi, Mosammaparast, Muller, Nevins, Noske, Parikh, Poon, Pumroy, Quan, Quensel, Rensen, Sakai, Scherf, Shen, Shi, Shiraki, Sillje, Smith, Smith, Soderholm, Song, Stawerski, Stella Tsai, Stewart, Tai, Torgerson, Turner, Turner, Wagstaff, Wang, Wang, Wang, Watt, Watt, Watt, Wellmann, Wiese, Winkler, Winnepenninckx, Wu, Yan, Yang, Yao, Yoshitake, Yu, Zender, Zheng, Zhou, Zhu, Zhu, Zienkiewicz   +117 more
core   +1 more source

Rev: beyond nuclear export

Journal of General Virology, 2009
Rev remains a hot topic. In this review, we revisit the insights that have been gained into the control of gene expression by the retroviral protein Rev and speculate on where current research is leading. We outline what is known about the role of Rev in translation and encapsidation and how these are linked to its more traditional role of nuclear ...
H C T, Groom, E C, Anderson, A M L, Lever   +2 more
openaire   +2 more sources

A Conserved CCCH-type Zinc Finger Protein Regulates mRNA Nuclear Adenylation and Export [PDF]

, 2011
Coupling of messenger RNA (mRNA) nuclear export with prior processing steps aids in the fidelity and efficiency of mRNA transport to the cytoplasm. In this study, we show that the processes of export and polyadenylation are coupled via the Drosophila ...
Farny, Natalie G., Gygi, Steven P., Hurt, Jessica A., Obar, Robert Alan, Silver, Pamela A., Zhai, Bo   +5 more
core   +1 more source

Nuclear dynamics: Formation of bodies and trafficking in plant nuclei

Frontiers in Plant Science, 2022
The existence of the nucleus distinguishes prokaryotes and eukaryotes. Apart from containing most of the genetic material, the nucleus possesses several nuclear bodies composed of protein and RNA molecules.
Eduardo Muñoz-Díaz, Eduardo Muñoz-Díaz, Julio Sáez-Vásquez, Julio Sáez-Vásquez   +3 more
doaj   +1 more source

Identification of a Small Molecule Inhibitor of Importin β Mediated Nuclear Import by Confocal On-Bead Screening of Tagged One-Bead One-Compound Libraries [PDF]

, 2010
In eukaryotic cells, proteins and RNAs are transported between the nucleus and the cytoplasm by nuclear import and export receptors. Over the past decade, small molecules that inhibit the nuclear export receptor CRM1 have been identified, most notably ...
Ambrus, Geza, Auer, Manfred, Bednenko, Janna, Gerace, Larry, Gstach, Hubert, Hintersteiner, Martin, Knox, Andrew J. S., Meisner, Nicole-Claudia, Schmied, Mario, Seifert, Jan-Marcus, Singer, Eric L.   +10 more
core   +1 more source

FAK nuclear export signal sequences [PDF]

FEBS Letters, 2008
Ubiquitously expressed focal adhesion kinase (FAK), a critical component in transducing signals from sites of cell contacts with extracellular matrix, was named after its typical localization in focal adhesions. A nuclear localization of FAK has been also reported and its scaffolding role in nucleus and requirement for p53 ubiquitination were only ...
Ossovskaya, Valeria, Lim, Ssang-Taek, Ota, Nobuyuki, Schlaepfer, David D., Ilic, Dusko   +4 more
openaire   +2 more sources

RNA nuclear export is blocked by poliovirus 2A protease and is concomitant with nucleoporin cleavage [PDF]

, 2009
Cytopathic viruses have developed successful strategies to block or, at least, to attenuate host interference with their replication. Here, we have analyzed the effects of poliovirus 2A protease on RNA nuclear export.
Carrasco Llamas, Luis, Castelló, Alfredo, Izquierdo, José M., Welnowska, Ewelina   +3 more
core   +1 more source

Nuclear RNA export in yeast [PDF]

FEBS Letters, 1999
Eukaryotic cells massively exchange macromolecules (proteins and RNAs) between the nucleus and cytoplasm through the nuclear pore complexes. Whereas a mechanistic picture emerges of how proteins are imported into and exported from the nucleus, less is known about nuclear exit of the different classes of RNAs. However, the yeast Saccharomyces cerevisiae
Sträßer, Katja, Hurt, Ed
openaire   +2 more sources

KLF4 Nuclear Export Requires ERK Activation and Initiates Exit from Naive Pluripotency

Stem Cell Reports, 2018
Summary: Cooperative action of a transcription factor complex containing OCT4, SOX2, NANOG, and KLF4 maintains the naive pluripotent state; however, less is known about the mechanisms that disrupt this complex, initiating exit from pluripotency.
Navroop K. Dhaliwal, Kamelia Miri, Scott Davidson, Hala Tamim El Jarkass, Jennifer A. Mitchell   +4 more
doaj   +1 more source