Results 1 to 10 of about 29,704,271 (175)

An Exportin-1-dependent microRNA biogenesis pathway during human cell quiescence. [PDF]

Proc Natl Acad Sci U S A, 2017
Significance Quiescence is a growth-arrested cellular state; genes involved in this process are finely regulated by several factors, including miRNAs.
Martinez I, Hayes KE, Barr JA, Harold AD, Xie M, Bukhari SIA, Vasudevan S, Steitz JA, DiMaio D.   +8 more
europepmc   +5 more sources

Therapeutic targeting of exportin-1 beyond nuclear export. [PDF]

Trends Pharmacol Sci
Exportin-1 (XPO1), also known as chromosome region maintenance 1 (CRM1), directly binds to and mediates the nuclear export of hundreds of cargo proteins. Blocking nuclear export by the selective inhibitors of nuclear export (SINEs) is a validated therapeutic axis in cancer and an active area of research.
Chen YF, Adams DJ.
europepmc   +3 more sources

Leptomycin B alters the subcellular distribution of CRM1 (Exportin 1). [PDF]

Biochem Biophys Res Commun, 2017
CRM1 (chromosome maintenance region 1, Exportin 1) binds to nuclear export signals and is required for nucleocytoplasmic transport of a large variety of proteins and RNP complexes. Leptomycin B (LMB), the first specific inhibitor of CRM1 identified, binds covalently to cysteine 528 in the nuclear export signal binding region of CRM1 leading to the ...
Rahmani K, Dean DA.
europepmc   +4 more sources

C646 degrades Exportin-1 to modulate p300 chromatin occupancy and function. [PDF]

Cell Chem Biol
Molecular glues can induce proximity between a target protein and ubiquitin ligases to induce target degradation, but strategies for their discovery remain limited. We screened 3,200 bioactive small molecules and identified that C646 requires neddylation-dependent protein degradation to induce cytotoxicity.
Chen YF, Rahman A, Sax JL, Atala Pleshinger MJ, Friedrich RM, Adams DJ.   +5 more
europepmc   +3 more sources

Exportin-1 functions as an adaptor for transcription factor-mediated docking of chromatin at the nuclear pore complex. [PDF]

Mol Cell
Ge T, Brickner DG, Zehr K, VanBelzen DJ, Zhang W, Caffalette C, Moeller GC, Ungerleider S, Marcou N, Jacob A, Nguyen VQ, Chait B, Rout MP, Brickner JH.   +13 more
europepmc   +1 more source

Exportin 1 governs the immunosuppressive functions of myeloid-derived suppressor cells in tumors through ERK1/2 nuclear export. [PDF]

Cell Mol Immunol
Daneshmandi S, Yan Q, Choi JE, Katsuta E, MacDonald CR, Goruganthu M, Roberts N, Repasky EA, Singh PK, Attwood K, Wang J, Landesman Y, McCarthy PL, Mohammadpour H.   +13 more
europepmc   +1 more source

Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma. [PDF]

Mol Cancer Ther, 2020
DeSisto JA, Flannery P, Lemma R, Pathak A, Mestnik S, Philips N, Bales NJ, Kashyap T, Moroze E, Venkataraman S, Kung AL, Carter BD, Landesman Y, Vibhakar R, Green AL.   +14 more
europepmc   +1 more source

Unbiased screening reveals that blocking exportin 1 overcomes resistance to PI3Kα inhibition in breast cancer. [PDF]

Signal Transduct Target Ther, 2019
Liu XL, Wang BB, Wang Y, Wang YX, Yang CH, Tan C, Zhang X, He QJ, Ding J, Meng LH.   +9 more
europepmc   +1 more source

Phase I/II Trial of Exportin 1 Inhibitor Selinexor plus Docetaxel in Previously Treated, Advanced KRAS-Mutant Non-Small Cell Lung Cancer. [PDF]

Clin Cancer Res
von Itzstein MS, Burns TF, Dowell JE, Horn L, Camidge DR, York SJ, Eaton KD, Kyle K, Fattah F, Liu J, Mu-Mosley H, Gupta A, Nadeem U, Gao A, Zhang S, Gerber DE.   +15 more
europepmc   +1 more source

Correction: Targeting mantle cell lymphoma metabolism and survival through simultaneous blockade of mTOR and nuclear transporter exportin-1. [PDF]

Oncotarget, 2019
Sekihara K, Saitoh K, Han L, Ciurea S, Yamamoto S, Kikkawa M, Kazuno S, Taka H, Kaga N, Arai H, Miida T, Andreeff M, Konopleva M, Tabe Y.   +13 more
europepmc   +1 more source