XPO1/Exportin-1 in Acute Myelogenous Leukemia; Biology and Therapeutic Targeting [PDF]
BiomoleculesExportin 1 is responsible for the export of hundreds of proteins, several RNA species and ribosomal components from the nucleus to the cytoplasm. Several transported proteins are important for regulation of cell proliferation and survival both in normal ...
Øystein Bruserud +3 more
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Exportin 1‐mediated nuclear/cytoplasmic trafficking controls drug sensitivity of classical Hodgkin's lymphoma [PDF]
Molecular Oncology, 2023 Exportin 1 (XPO1) is the main nuclear export receptor that controls the subcellular trafficking and the functions of major regulatory proteins. XPO1 is overexpressed in various cancers and small inhibitors of nuclear export (SINEs) have been developed to
Mélody Caillot +10 more
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Effect of Exportin 1/XPO1 Nuclear Export Pathway Inhibition on Coronavirus Replication [PDF]
Viruses, 2023 The nucleocytoplasmic transport of proteins using XPO1 (exportin 1) plays a vital role in cell proliferation and survival. Many viruses also exploit this pathway to promote infection and replication.
Masmudur M. Rahman +8 more
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Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1 [PDF]
Scientific Reports, 2018 TDP-43 and FUS are nuclear proteins with multiple functions in mRNA processing. They play key roles in ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia), where they are partially lost from the nucleus and aggregate in the cytoplasm of
Helena Ederle +7 more
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Exportin 1 (XPO1) Expression and Effectiveness of XPO1 Inhibitor Against Canine Lymphoma Cell Lines [PDF]
Veterinary SciencesLymphoma is the most common neoplasm of lymphoid tissues in dogs. Exportin 1 (XPO1) is an important major nuclear receptor for exporting proteins and RNA species.
Hardany Primarizky +4 more
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Exportin 1 as a Therapeutic Target to Overcome Drug Resistance in Lung Cancer [PDF]
CellsNon-small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality, with therapeutic resistance continuing to limit long-term responses.
Maria Vittoria Di Marco +3 more
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Therapeutic Potential of Exportin 1 and Aurora Kinase A Inhibition in Multiple Myeloma Cells [PDF]
Hematology ReportsBackground/Objectives: Aurora kinases (AURKs) are key regulators of mitosis, and their dysregulation contributes to plasma cell disorders, including multiple myeloma (MM) and plasma cell leukemia (PCL). Methods: The expression and prognostic relevance of
Seiichi Okabe +6 more
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Nuclear Exportin 1 (XPO1) Binds to the Nuclear Localization/Export Signal of the Turnip Mosaic Virus NIb to Promote Viral Infection [PDF]
Frontiers in Microbiology, 2022 The nuclear localization signal (NLS) and nuclear export signal (NES) are key signatures of proteins for controlling nuclear import and export. The NIb protein of turnip mosaic virus (TuMV) is an RNA-dependent RNA polymerase (RdRP) that is absolutely ...
Mingzhen Zhang +11 more
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Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity [PDF]
Cells, 2019 DEAD-box helicase 3, X-linked (DDX3X) regulates the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR)-mediated antiviral response, but can also be a host factor contributing to the replication of viruses of significance to human health, such as ...
Steven M. Heaton +5 more
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The nuclear export protein exportin‐1 in solid malignant tumours: From biology to clinical trials [PDF]
Clinical and Translational MedicineBackground Exportin‐1 (XPO1), a crucial protein regulating nuclear‐cytoplasmic transport, is frequently overexpressed in various cancers, driving tumor progression and drug resistance. This makes XPO1 an attractive therapeutic target.
Chuanxi Lai, Lingna Xu, Sheng Dai
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