Exportin 1 (XPO1) Expression and Effectiveness of XPO1 Inhibitor Against Canine Lymphoma Cell Lines. [PDF]
Vet SciLymphoma is the most common neoplasm of lymphoid tissues in dogs. Exportin 1 (XPO1) is an important major nuclear receptor for exporting proteins and RNA species.
Primarizky H +4 more
europepmc +2 more sources
Exportin 1 (Crm1p) Is an Essential Nuclear Export Factor [PDF]
Cell, 1997 Nuclear protein export is mediated by nuclear export signals (NESs), but the mechanisms governing this transport process are not well understood. Using a novel protein export assay in S.
Ford, Charleen S. +3 more
core +4 more sources
Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma. [PDF]
Neuro-Oncology, 2015 Glioblastoma (GBM) is poorly responsive to current chemotherapy. The nuclear transporter exportin 1 (XPO1, CRM1) is often highly expressed in GBM, which may portend a poor prognosis. Here, we determine the efficacy of novel selective inhibitors of nuclear export (SINE) specific to XPO1 in preclinical models of GBM.Seven patient-derived GBM lines were ...
David S Knoff +2 more
exaly +5 more sources
P006 (0037) RECURRENT EXPORTIN 1 MUTATIONS IN PATIENTS WITH CLASSICAL HODGKIN LYMPHOMA [PDF]
Hemasphere, 2018 europepmc +3 more sources
Differential expression of exportin 1 in cancers of the breast.
, 2022 Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients ...
Shahan Mamoor
core +2 more sources
Targeting the nuclear export receptor exportin-1 in acute myeloid leukaemia: From biology to clinical translation. [PDF]
Clin Transl MedBackground Exportinâ1 (XPO1), a key regulator of nucleocytoplasmic transport, is frequently dysregulated in acute myeloid leukemia (AML) and contributes to leukemogenesis, disease progression and therapeutic resistance.
Liu Y, Yun X, Ding W, Li S, Liu H.
europepmc +2 more sources
Nuclear exportin receptor CAS regulates the NPI-1-mediated nuclear import of HIV-1 Vpr. [PDF]
PLoS ONE, 2011 Vpr, an accessory protein of human immunodeficiency virus type 1, is a multifunctional protein that plays an important role in viral replication. We have previously shown that the region between residues 17 and 74 of Vpr (Vpr(N17C74)) contained a bona ...
Eri Takeda +6 more
doaj +4 more sources
In vitro toxicity and efficacy of verdinexor, an exportin 1 inhibitor, on opportunistic viruses affecting immunocompromised individuals. [PDF]
PLoS One, 2018 Infection of immunocompromised individuals with normally benign opportunistic viruses is a major health burden globally. Infections with viruses such as Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), Kaposi's sarcoma virus (KSHV), adenoviruses ...
Widman DG +3 more
europepmc +2 more sources
Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 down-regulation in lung and prostate cancers. [PDF]
Sci Transl Med, 2023 In lung and prostate adenocarcinomas, neuroendocrine (NE) transformation to an aggressive derivative resembling small cell lung cancer (SCLC) is associated with poor prognosis.
Quintanal-Villalonga A +24 more
europepmc +2 more sources
Understanding Exportin-1 as an Anti-Cancer Target [PDF]
, 2018 Exportin-1 is a promising new anti-cancer target for selective inhibitors of nuclear export (SINE) molecules. Selinexor is a first-in-class SINE molecule in clinical trials for a variety of different cancers. Selinexor and other SINE molecules covalently
Burke, Russell Thomas
core +8 more sources