Results 21 to 30 of about 12,090 (148)
Journal of Hematology & Oncology, 2021 Patients with RR DLBCL who have received ≥ 2 lines of therapy have limited treatment options and an expected overall survival (OS) of
Marie Maerevoet +33 more
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Leptomycin B alters the subcellular distribution of CRM1 (Exportin 1). [PDF]
Biochem Biophys Res Commun, 2017 CRM1 (chromosome maintenance region 1, Exportin 1) binds to nuclear export signals and is required for nucleocytoplasmic transport of a large variety of proteins and RNP complexes. Leptomycin B (LMB), the first specific inhibitor of CRM1 identified, binds covalently to cysteine 528 in the nuclear export signal binding region of CRM1 leading to the ...
Rahmani K, Dean DA.
europepmc +4 more sources
Exportin 1 (Crm1p) Is an Essential Nuclear Export Factor [PDF]
Cell, 1997 Nuclear protein export is mediated by nuclear export signals (NESs), but the mechanisms governing this transport process are not well understood. Using a novel protein export assay in S. cerevisiae, we identify CRM1 as an essential mediator of nuclear protein export in yeast.
Stade, Katrin +3 more
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Ecotoxicology and Environmental Safety, 2021 Cadmium is an environmental metal pollutant that has been a focus of research in recent years, which is reported to cause bone disease; however, its skeletal toxicity and the mechanism involved are not yet fully known. Therefore, this study used MC3T3-E1
Ling Ou +8 more
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Journal of Hematology & Oncology, 2021 Therapeutic regimens for previously treated multiple myeloma (MM) may not provide prolonged disease control and are often complicated by significant adverse events, including peripheral neuropathy.
Maria V. Mateos +36 more
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XPO1 (exportin 1 (CRM1 homolog, yeast)) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on XPO1 (exportin 1 (CRM1 homolog, yeast)), with data on DNA, on the protein encoded, and where the gene is implicated.
Ruggiero A, Giubettini M, Lavia P
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Translational Oncology, 2021 Across many cancer types in adults, upregulation of the nuclear-to-cytoplasmic transport protein Exportin-1 (XPO1) correlates with poor outcome and responsiveness to selinexor, an FDA-approved XPO1 inhibitor.
Basia Galinski +9 more
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Crop Journal, 2023 The transport of proteins to and from the nucleus is necessary for many cellular processes and is one of the ways plants respond to developmental signals and environmental stresses.
Qiufei Peng +5 more
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Inhibition of XPO-1 Mediated Nuclear Export through the Michael-Acceptor Character of Chalcones
Pharmaceuticals, 2021 The nuclear export receptor exportin-1 (XPO1, CRM1) mediates the nuclear export of proteins that contain a leucine-rich nuclear export signal (NES) towards the cytoplasm.
Marta Gargantilla +6 more
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Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer. [PDF]
Transl Cancer Res, 2017 Gao W.
europepmc +4 more sources