Crop Journal, 2023 The transport of proteins to and from the nucleus is necessary for many cellular processes and is one of the ways plants respond to developmental signals and environmental stresses.
Qiufei Peng +5 more
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Inhibition of XPO-1 Mediated Nuclear Export through the Michael-Acceptor Character of Chalcones
Pharmaceuticals, 2021 The nuclear export receptor exportin-1 (XPO1, CRM1) mediates the nuclear export of proteins that contain a leucine-rich nuclear export signal (NES) towards the cytoplasm.
Marta Gargantilla +6 more
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Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer. [PDF]
Transl Cancer Res, 2017 Gao W.
europepmc +4 more sources
PLoS Pathogens, 2018 Orientia tsutsugamushi causes scrub typhus, a potentially fatal infection that threatens over one billion people. Nuclear translocation of the transcription factor, NF-κB, is the central initiating cellular event in the antimicrobial response.
Sean M Evans +3 more
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The evolution of core proteins involved in microRNA biogenesis
BMC Evolutionary Biology, 2008 Background MicroRNAs (miRNAs) are a recently discovered class of non-coding RNAs (ncRNAs) which play important roles in eukaryotic gene regulation. miRNA biogenesis and activation is a complex process involving multiple protein catalysts and involves the
Brown James R +2 more
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Loss of p53 expression in cancer cells alters cell cycle response after inhibition of exportin-1 but does not prevent cell death [PDF]
Cell Cycle, 2018 James D. Orth
exaly +2 more sources
Combined Targeting of Estrogen Receptor Alpha and Exportin 1 in Metastatic Breast Cancers. [PDF]
Cancers (Basel), 2020 The majority of breast cancer specific deaths in women with estrogen receptor positive (ER+) tumors occur due to metastases that are resistant to therapy. There is a critical need for novel therapeutic approaches to achieve tumor regression and/or maintain therapy responsiveness in metastatic ER+ tumors. The objective of this study was to elucidate the
Cotul EK +22 more
europepmc +4 more sources
TFIIA transcriptional activity is controlled by a ‘cleave-and-run’ Exportin-1/Taspase 1-switch [PDF]
Journal of Molecular Cell Biology, 2017 Transcription factor TFIIA is controlled by complex regulatory networks including proteolysis by the protease Taspase 1, though the full impact of cleavage remains elusive. Here, we demonstrate that in contrast to the general assumption, de novo produced TFIIA is rapidly confined to the cytoplasm via an evolutionary conserved nuclear export signal (NES,
Schrenk, Christian +13 more
openaire +3 more sources
Small-Molecule Antagonist Targeting Exportin‑1 via Rational Structure-Based Discovery
, 2020 Exportin-1 (also named as CRM1) plays a prominent role in autoimmune disorders and has emerged as a potential therapeutic target for colitis. Here we report on the rational structure-based discovery of a small-molecule antagonist of exportin-1, LFS-829 ...
Xiangyu Long +33 more
core +2 more sources
New insights into YAP/TAZ nucleo‐cytoplasmic shuttling: new cancer therapeutic opportunities?
Molecular Oncology, 2019 Yes‐associated protein (YAP) and transcriptional co‐activator with PDZ‐binding motif (TAZ), the main effectors of the Hippo pathway, are emerging as important players in cancer biology and therapy response.
Michal Shreberk‐Shaked, Moshe Oren
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