Combined Targeting of Estrogen Receptor Alpha and Exportin 1 in Metastatic Breast Cancers. [PDF]
Cancers (Basel), 2020 The majority of breast cancer specific deaths in women with estrogen receptor positive (ER+) tumors occur due to metastases that are resistant to therapy. There is a critical need for novel therapeutic approaches to achieve tumor regression and/or maintain therapy responsiveness in metastatic ER+ tumors. The objective of this study was to elucidate the
Cotul EK +22 more
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PLoS Pathogens, 2018 Orientia tsutsugamushi causes scrub typhus, a potentially fatal infection that threatens over one billion people. Nuclear translocation of the transcription factor, NF-κB, is the central initiating cellular event in the antimicrobial response.
Sean M Evans +3 more
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The evolution of core proteins involved in microRNA biogenesis
BMC Evolutionary Biology, 2008 Background MicroRNAs (miRNAs) are a recently discovered class of non-coding RNAs (ncRNAs) which play important roles in eukaryotic gene regulation. miRNA biogenesis and activation is a complex process involving multiple protein catalysts and involves the
Brown James R +2 more
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C646 degrades Exportin-1 to modulate p300 chromatin occupancy and function. [PDF]
Cell Chem BiolMolecular glues can induce proximity between a target protein and ubiquitin ligases to induce target degradation, but strategies for their discovery remain limited. We screened 3,200 bioactive small molecules and identified that C646 requires neddylation-dependent protein degradation to induce cytotoxicity.
Chen YF +5 more
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Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma. [PDF]
Neuro Oncol, 2015 Glioblastoma (GBM) is poorly responsive to current chemotherapy. The nuclear transporter exportin 1 (XPO1, CRM1) is often highly expressed in GBM, which may portend a poor prognosis. Here, we determine the efficacy of novel selective inhibitors of nuclear export (SINE) specific to XPO1 in preclinical models of GBM.Seven patient-derived GBM lines were ...
Green AL +12 more
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TFIIA transcriptional activity is controlled by a ‘cleave-and-run’ Exportin-1/Taspase 1-switch [PDF]
Journal of Molecular Cell Biology, 2017 Transcription factor TFIIA is controlled by complex regulatory networks including proteolysis by the protease Taspase 1, though the full impact of cleavage remains elusive. Here, we demonstrate that in contrast to the general assumption, de novo produced TFIIA is rapidly confined to the cytoplasm via an evolutionary conserved nuclear export signal (NES,
Schrenk, Christian +13 more
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Loss of p53 expression in cancer cells alters cell cycle response after inhibition of exportin-1 but does not prevent cell death [PDF]
Cell Cycle, 2018 James Orth, Soyeon Park
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New insights into YAP/TAZ nucleo‐cytoplasmic shuttling: new cancer therapeutic opportunities?
Molecular Oncology, 2019 Yes‐associated protein (YAP) and transcriptional co‐activator with PDZ‐binding motif (TAZ), the main effectors of the Hippo pathway, are emerging as important players in cancer biology and therapy response.
Michal Shreberk‐Shaked, Moshe Oren
doaj +1 more source
Structural determinants of nuclear export signal orientation in binding to exportin CRM1
eLife, 2015 The Chromosome Region of Maintenance 1 (CRM1) protein mediates nuclear export of hundreds of proteins through recognition of their nuclear export signals (NESs), which are highly variable in sequence and structure.
Ho Yee Joyce Fung +3 more
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Exportin 1 Mediates Nuclear Export of the Kinetoplastid Spliced Leader RNA [PDF]
Eukaryotic Cell, 2003 ABSTRACTThe kinetoplastid protozoan spliced leader (SL) RNA is the common substrate pre-mRNA utilized in alltrans-splicing reactions. Here we show by fluorescence in situ hybridization that the SL RNA is present in the cytoplasm ofLeishmania tarentolaeandTrypanosoma brucei.
Gusti M, Zeiner +2 more
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