Therapeutic Targeting of Exportin-1 in Childhood Cancer [PDF]
Cancers, 2021 Overexpression of Exportin-1 (XPO1), a key regulator of nuclear-to-cytoplasmic transport, is associated with inferior patient outcomes across a range of adult malignancies. Targeting XPO1 with selinexor has demonstrated promising results in clinical trials, leading to FDA approval of its use for multiple relapsed/refractory cancers.
Daniel A Weiser +2 more
exaly +5 more sources
Human Exportin-1 is a Target for Combined Therapy of HIV and AIDS Related Lymphoma [PDF]
EBioMedicine, 2015 Infection with HIV ultimately leads to advanced immunodeficiency resulting in an increased incidence of cancer. For example primary effusion lymphoma (PEL) is an aggressive non-Hodgkin lymphoma with very poor prognosis that typically affects HIV infected
Eline Boons +13 more
doaj +4 more sources
Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1 [PDF]
Scientific Reports, 2018 TDP-43 and FUS are nuclear proteins with multiple functions in mRNA processing. They play key roles in ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia), where they are partially lost from the nucleus and aggregate in the cytoplasm of
Helena Ederle +7 more
doaj +7 more sources
P006 (0037) RECURRENT EXPORTIN 1 MUTATIONS IN PATIENTS WITH CLASSICAL HODGKIN LYMPHOMA [PDF]
HemaSphere, 2018 doaj +3 more sources
Nuclear exportin receptor CAS regulates the NPI-1-mediated nuclear import of HIV-1 Vpr. [PDF]
PLoS ONE, 2011 Vpr, an accessory protein of human immunodeficiency virus type 1, is a multifunctional protein that plays an important role in viral replication. We have previously shown that the region between residues 17 and 74 of Vpr (Vpr(N17C74)) contained a bona ...
Eri Takeda +6 more
doaj +4 more sources
In vitro toxicity and efficacy of verdinexor, an exportin 1 inhibitor, on opportunistic viruses affecting immunocompromised individuals. [PDF]
PLoS ONE, 2018 Infection of immunocompromised individuals with normally benign opportunistic viruses is a major health burden globally. Infections with viruses such as Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), Kaposi's sarcoma virus (KSHV), adenoviruses ...
Douglas G Widman +3 more
doaj +2 more sources
Exportin 1 inhibition as antiviral therapy. [PDF]
Drug Discov Today, 2020 Coronavirus 2019 (COVID-19; caused by Severe Acute Respiratory Syndrome Coronavirus 2; SARS-CoV-2) is a currently global health problem. Previous studies showed that blocking nucleocytoplasmic transport with exportin 1 (XPO1) inhibitors originally developed as anticancer drugs can quarantine key viral accessory proteins and genomic materials in the ...
Uddin MH, Zonder JA, Azmi AS.
europepmc +3 more sources
Targeting of nucleo‑cytoplasmic transport factor exportin 1 in malignancy (Review). [PDF]
Med Int (Lond), 2022 Nuclear pore complexes (NPCs) regulate the entry and exit of molecules from the cell nucleus. Small molecules pass through NPCs by diffusion while large molecules enter and exit the nucleus by karyopherins, which serve as transport factors. Exportin-1 (XPO1) is a protein that is an important member of the karyopherin family and carries macromolecules ...
Özdaş S, Canatar İ.
europepmc +4 more sources
Therapeutic targeting of exportin-1 beyond nuclear export. [PDF]
Trends Pharmacol SciExportin-1 (XPO1), also known as chromosome region maintenance 1 (CRM1), directly binds to and mediates the nuclear export of hundreds of cargo proteins. Blocking nuclear export by the selective inhibitors of nuclear export (SINEs) is a validated therapeutic axis in cancer and an active area of research.
Chen YF, Adams DJ.
europepmc +3 more sources
XPO1E571K Mutation Modifies Exportin 1 Localisation and Interactome in B-cell Lymphoma. [PDF]
Cancers (Basel), 2020 The XPO1 gene encodes exportin 1 (XPO1) that controls the nuclear export of cargo proteins and RNAs. Almost 25% of primary mediastinal B-cell lymphoma (PMBL) and classical Hodgkin lymphoma (cHL) cases harboured a recurrent XPO1 point mutation (NM_003400, chr2:g61718472C>T) resulting in the E571K substitution within the hydrophobic groove of the ...
Miloudi H +9 more
europepmc +5 more sources