XPO1/Exportin-1 in Acute Myelogenous Leukemia; Biology and Therapeutic Targeting [PDF]
BiomoleculesExportin 1 is responsible for the export of hundreds of proteins, several RNA species and ribosomal components from the nucleus to the cytoplasm. Several transported proteins are important for regulation of cell proliferation and survival both in normal ...
Håkon Reikvam +2 more
exaly +9 more sources
Therapeutic Targeting of Exportin-1 in Childhood Cancer [PDF]
Cancers, 2021 Overexpression of Exportin-1 (XPO1), a key regulator of nuclear-to-cytoplasmic transport, is associated with inferior patient outcomes across a range of adult malignancies.
Daniel Weiser +2 more
exaly +6 more sources
Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1. [PDF]
Sci Rep, 2018 TDP-43 and FUS are nuclear proteins with multiple functions in mRNA processing. They play key roles in ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia), where they are partially lost from the nucleus and aggregate in the cytoplasm of
Ederle H +7 more
europepmc +9 more sources
Effect of Exportin 1/XPO1 Nuclear Export Pathway Inhibition on Coronavirus Replication. [PDF]
Viruses, 2023 The nucleocytoplasmic transport of proteins using XPO1 (exportin 1) plays a vital role in cell proliferation and survival. Many viruses also exploit this pathway to promote infection and replication.
Rahman MM +8 more
europepmc +5 more sources
Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity. [PDF]
Cells, 2019 DEAD-box helicase 3, X-linked (DDX3X) regulates the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR)-mediated antiviral response, but can also be a host factor contributing to the replication of viruses of significance to human health, such as ...
Heaton SM +5 more
europepmc +5 more sources
Exportin 1 as a Therapeutic Target to Overcome Drug Resistance in Lung Cancer. [PDF]
CellsNon-small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality, with therapeutic resistance continuing to limit long-term responses.
Di Marco MV +3 more
europepmc +4 more sources
Therapeutic Potential of Exportin 1 and Aurora Kinase A Inhibition in Multiple Myeloma Cells. [PDF]
Hematol RepBackground/Objectives: Aurora kinases (AURKs) are key regulators of mitosis, and their dysregulation contributes to plasma cell disorders, including multiple myeloma (MM) and plasma cell leukemia (PCL). Methods: The expression and prognostic relevance of
Okabe S +6 more
europepmc +5 more sources
The nuclear export protein exportin-1 in solid malignant tumours: From biology to clinical trials. [PDF]
Clin Transl MedBackground Exportin‐1 (XPO1), a crucial protein regulating nuclear‐cytoplasmic transport, is frequently overexpressed in various cancers, driving tumor progression and drug resistance. This makes XPO1 an attractive therapeutic target.
Lai C, Xu L, Dai S.
europepmc +3 more sources
Specific inhibition of the nuclear exporter exportin-1 attenuates kidney cancer growth. [PDF]
PLoS One, 2014 PurposeDespite the advent of FDA-approved therapeutics to a limited number of available targets (kinases and mTOR), PFS of kidney cancer (RCC) has been extended only one to two years due to the development of drug resistance.
Wettersten HI +5 more
europepmc +7 more sources
Exportin 1-mediated nuclear/cytoplasmic trafficking controls drug sensitivity of classical Hodgkin's lymphoma. [PDF]
Mol Oncol, 2023 Exportin 1 (XPO1) is the main nuclear export receptor that controls the subcellular trafficking and the functions of major regulatory proteins. XPO1 is overexpressed in various cancers and small inhibitors of nuclear export (SINEs) have been developed to
Caillot M +10 more
europepmc +2 more sources