Specific inhibition of the nuclear exporter exportin-1 attenuates kidney cancer growth. [PDF]
PLoS ONE, 2014 PurposeDespite the advent of FDA-approved therapeutics to a limited number of available targets (kinases and mTOR), PFS of kidney cancer (RCC) has been extended only one to two years due to the development of drug resistance.
Hiromi I Wettersten +5 more
doaj +7 more sources
Human Exportin-1 is a Target for Combined Therapy of HIV and AIDS Related Lymphoma
EBioMedicine, 2015 Infection with HIV ultimately leads to advanced immunodeficiency resulting in an increased incidence of cancer. For example primary effusion lymphoma (PEL) is an aggressive non-Hodgkin lymphoma with very poor prognosis that typically affects HIV infected
Eline Boons +13 more
doaj +5 more sources
Exportin 1 (Crm1p) Is an Essential Nuclear Export Factor [PDF]
Cell, 1997 Nuclear protein export is mediated by nuclear export signals (NESs), but the mechanisms governing this transport process are not well understood. Using a novel protein export assay in S. cerevisiae, we identify CRM1 as an essential mediator of nuclear protein export in yeast.
Karsten Weis
exaly +3 more sources
P006 (0037) RECURRENT EXPORTIN 1 MUTATIONS IN PATIENTS WITH CLASSICAL HODGKIN LYMPHOMA [PDF]
HemaSphere, 2018 doaj +3 more sources
Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma. [PDF]
Neuro Oncol, 2015 Glioblastoma (GBM) is poorly responsive to current chemotherapy. The nuclear transporter exportin 1 (XPO1, CRM1) is often highly expressed in GBM, which may portend a poor prognosis. Here, we determine the efficacy of novel selective inhibitors of nuclear export (SINE) specific to XPO1 in preclinical models of GBM.Seven patient-derived GBM lines were ...
Green AL +12 more
europepmc +5 more sources
Nuclear exportin receptor CAS regulates the NPI-1-mediated nuclear import of HIV-1 Vpr. [PDF]
PLoS ONE, 2011 Vpr, an accessory protein of human immunodeficiency virus type 1, is a multifunctional protein that plays an important role in viral replication. We have previously shown that the region between residues 17 and 74 of Vpr (Vpr(N17C74)) contained a bona ...
Eri Takeda +6 more
doaj +4 more sources
In vitro toxicity and efficacy of verdinexor, an exportin 1 inhibitor, on opportunistic viruses affecting immunocompromised individuals. [PDF]
PLoS ONE, 2018 Infection of immunocompromised individuals with normally benign opportunistic viruses is a major health burden globally. Infections with viruses such as Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), Kaposi's sarcoma virus (KSHV), adenoviruses ...
Douglas G Widman +3 more
doaj +2 more sources
Importin 7 and Exportin 1 Link c-Myc and p53 to Regulation of Ribosomal Biogenesis [PDF]
Molecular Cell, 2012 Members of the β-karyopherin family mediate nuclear import of ribosomal proteins and export of ribosomal subunits, both required for ribosome biogenesis. We report that transcription of the β-karyopherin genes importin 7 (IPO7) and exportin 1 (XPO1), and several additional nuclear import receptors, is regulated positively by c-Myc and negatively by p53.
Kristina Grabusic +2 more
exaly +4 more sources
Therapeutic Targeting of Exportin-1 in Childhood Cancer. [PDF]
Cancers (Basel), 2021 Overexpression of Exportin-1 (XPO1), a key regulator of nuclear-to-cytoplasmic transport, is associated with inferior patient outcomes across a range of adult malignancies. Targeting XPO1 with selinexor has demonstrated promising results in clinical trials, leading to FDA approval of its use for multiple relapsed/refractory cancers.
Galinski B +6 more
europepmc +4 more sources
Exportin 1 inhibition as antiviral therapy. [PDF]
Drug Discov Today, 2020 Coronavirus 2019 (COVID-19; caused by Severe Acute Respiratory Syndrome Coronavirus 2; SARS-CoV-2) is a currently global health problem. Previous studies showed that blocking nucleocytoplasmic transport with exportin 1 (XPO1) inhibitors originally developed as anticancer drugs can quarantine key viral accessory proteins and genomic materials in the ...
Uddin MH, Zonder JA, Azmi AS.
europepmc +3 more sources