Results 21 to 30 of about 5,881 (166)
Molecular Oncology, 2023 Exportin 1 (XPO1) is the main nuclear export receptor that controls the subcellular trafficking and the functions of major regulatory proteins. XPO1 is overexpressed in various cancers and small inhibitors of nuclear export (SINEs) have been developed to
Mélody Caillot +10 more
doaj +1 more source
Protein biomarkers for response to XPO1 inhibition in hematologic malignancies
Journal of Cellular and Molecular Medicine, 2022 Abstract XPO1 (Exportin-1) is the nuclear export protein responsible for the normal shuttling of several proteins and RNA species between the nucleocytoplasmic compartment of eukaryotic cells. XPO1 recognizes the nuclear export signal (NES) of its cargo proteins to facilitate its export.
Tulasigeri M. Totiger +9 more
openaire +2 more sources
Journal of Experimental & Clinical Cancer Research, 2021 Background High-risk neuroblastoma patients have a 5-year survival rate of less than 50%. It’s an urgent need to identify new therapeutic targets and the appropriate drugs.
Lijia Pan +5 more
doaj +1 more source
XPO1, therapeutic...and prognostic target in sarcomas
Oncoscience, 2016 In a recent issue of Oncotarget [1], Nakayama et al. showed the anti-tumor activity of selinexor, an inhibitor of exportin 1, against a wide variety of sarcoma preclinical models, including several pathological subtypes of soft tissue sarcomas (STS).
Bertucci, François +2 more
openaire +3 more sources
International Journal of Molecular Sciences, 2023 Acute myeloid leukemia (AML) is a high-mortality malignancy with poor outcomes. Azacitidine induces cell death and demonstrates treatment effectiveness against AML. Selinexor (KPT-330) exhibited significant benefits in combination with typical induction treatment for AML patients.
Huideng Long +4 more
openaire +2 more sources
Inhibition of XPO-1 Mediated Nuclear Export through the Michael-Acceptor Character of Chalcones
Pharmaceuticals, 2021 The nuclear export receptor exportin-1 (XPO1, CRM1) mediates the nuclear export of proteins that contain a leucine-rich nuclear export signal (NES) towards the cytoplasm.
Marta Gargantilla +6 more
doaj +1 more source
PLoS ONE, 2015 The DEAD-box RNA helicase Ded1, which is essential in yeast and known as DDX3 in humans, shuttles between the nucleus and cytoplasm and takes part in several basic processes including RNA processing and translation.
Glenn Hauk, Gregory D Bowman
doaj +1 more source
Give me a SINE: how Selective Inhibitors of Nuclear Export modulate autophagy and aging
Molecular & Cellular Oncology, 2018 Autophagy is a cellular recycling process leading to lysosomal degradation of damaged macromolecules, which can protect cells against aging. The transcription factor EB (TFEB), a major transcriptional regulator of genes involved in autophagy and ...
A.V. Kumar +5 more
doaj +1 more source
Preclinical activity of selinexor, an inhibitor of XPO1, in sarcoma
Oncotarget, 2016 Selinexor is an orally bioavailable selective inhibitor of nuclear export that has been demonstrated to have preclinical activity in various cancer types and that is currently in Phase I and II clinical trials for advanced cancers. In this study, we evaluated the effects of selinexor in several preclinical models of various sarcoma subtypes.
Nakayama, Robert +7 more
openaire +5 more sources
Simultaneous targeting of XPO1 and BCL2 as an effective treatment strategy for double-hit lymphoma
Journal of Hematology & Oncology, 2019 Double-hit lymphoma (DHL) is among the most aggressive and chemoresistant lymphoma subtypes. DHLs carry genomic abnormalities in MYC, BCL2, and/or BCL6 oncogenes. Due to the simultaneous overexpression of these driver oncogenes, DHLs are highly resistant
Yuanhui Liu +4 more
doaj +1 more source