Results 21 to 30 of about 7,047 (156)

Impact of XPO1 mutations on survival outcomes in metastatic non-small cell lung cancer (NSCLC) [PDF]

, 2021
BACKGROUND: Nuclear protein transport is essential in guiding the traffic of important proteins and RNAs between the nucleus and cytoplasm. Export of proteins from the nucleus is mostly regulated by Exportin 1 (XPO1).
Uddin, Md Hafiz, Magee, Dan, Raez, Luis E, Al Hallak, Mohammed, Uddin, Md, Ma, Patrick C., Asad, Mohammad Fahad B, Lopes, Gilberto, Xiu, Joanne, Azmi, Asfar S., Demeure, Michael, Baca, Yasmine, Uddin, Md. Hafiz, Xia, Bing, Mamdani, Hirva, Kim, Chul, Raez, Luis E., Nagasaka, Misako, Nieva, Jorge, Bepler, Gerold, Puri, Sonam, Korn, Wolfgang Michael, Korn, W Michael, Nieva, Jorge J., Ma, Patrick C, Liu, Stephen V., Liu, Stephen, Asad, Mohammad, Asad, Mohammad Fahad B., Ma, Patrick, Borghaei, Hossein, Sukari, Ammar, Nieva, Jorge J, Raez, Luis, Korn, W, Demeure, Michael J., Liu, Stephen V, Al Hallak, Mohammed Najeeb, Uprety, Dipesh, Azmi, Asfar, Demeure, Michael J, Azmi, Asfar S, Hallak, Mohammed Najeeb Al   +42 more
core   +2 more sources

Inhibition of XPO1 with KPT-330 induces autophagy-dependent apoptosis in gallbladder cancer by activating the p53/mTOR pathway

Journal of Translational Medicine, 2022
Background Gallbladder cancer (GBC) is a highly aggressive malignant cancer in the biliary system with poor prognosis. XPO1 (chromosome region maintenance 1 or CRM1) mediates the nuclear export of several proteins, mainly tumor suppressors.
Cheng Zhao, Zi-yi Yang, Jian Zhang, Ou Li, Shi-lei Liu, Chen Cai, Yi-jun Shu, Li-jia Pan, Wei Gong, Ping Dong   +9 more
doaj   +1 more source

XPO1-dependent nuclear export as a target for cancer therapy

Journal of Hematology & Oncology, 2020
Cellular homeostasis requires the proper nuclear-cytoplasmic partitioning of large molecules, which is often deregulated in cancer. XPO1 is an export receptor responsible for the nuclear-cytoplasmic transport of hundreds of proteins and multiple RNA ...
Nancy G. Azizian, Yulin Li
doaj   +1 more source

Antitumor efficacy of XPO1 inhibitor Selinexor in KRAS-mutant lung adenocarcinoma patient-derived xenografts

Translational Oncology, 2021
Gain-of-function Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations occur in 25% of lung adenocarcinomas, and these tumors are challenging to treat.
Joshua C. Rosen, Jessica Weiss, Nhu-An Pham, Quan Li, Sebastiao N. Martins-Filho, Yuhui Wang, Ming-Sound Tsao, Nadeem Moghal   +7 more
doaj   +1 more source

Targeting XPO1 enhances innate immune response and inhibits KSHV lytic replication during primary infection by nuclear stabilization of the p62 autophagy adaptor protein

Cell Death and Disease, 2021
Nucleocytoplasmic transport of signaling modulators is essential for regulating cellular responses to extracellular stimulation and stress, as well as pathogen infection. Exportin 1 (XPO1), also known as chromosomal maintenance 1 (CRM1), mediates nuclear
Wen Meng, Shou-Jiang Gao
doaj   +1 more source

Exportin 1‐mediated nuclear/cytoplasmic trafficking controls drug sensitivity of classical Hodgkin's lymphoma

Molecular Oncology, 2023
Exportin 1 (XPO1) is the main nuclear export receptor that controls the subcellular trafficking and the functions of major regulatory proteins. XPO1 is overexpressed in various cancers and small inhibitors of nuclear export (SINEs) have been developed to
Mélody Caillot, Hadjer Miloudi, Antoine Taly, Nuria Profitós‐Pelejà, Juliana C. Santos, Marcelo L. Ribeiro, Elsa Maitre, Simon Saule, Gaël Roué, Fabrice Jardin, Brigitte Sola   +10 more
doaj   +1 more source

A Radiosensitivity Gene Signature and XPO1 Predict Clinical Outcomes for Glioma Patients

Frontiers in Oncology, 2020
Objective: Glioma is the most common and fatal primary brain tumor that has a high risk of recurrence in adults. Identification of predictive biomarkers is necessary to optimize therapeutic strategies. This study investigated the predictive efficacy of a
Shan Wu, Qiao Qiao, Guang Li
doaj   +1 more source

Xpo1 As A Therapeutic Target In Gastric Cancer [PDF]

, 2022
Gastric cancer is a leading cause of cancer related deaths worldwide. Throughout the world, there is around one million new diagnosed cases per year and only an approximate 25% survival rate. This disease is highly heterogeneous, chemotherapy resistant
Sexton, Rachel
core   +1 more source

XPO1/CRM1 is a promising prognostic indicator for neuroblastoma and represented a therapeutic target by selective inhibitor verdinexor

Journal of Experimental & Clinical Cancer Research, 2021
Background High-risk neuroblastoma patients have a 5-year survival rate of less than 50%. It’s an urgent need to identify new therapeutic targets and the appropriate drugs.
Lijia Pan, Cheng Cheng, Peiwen Duan, Kai Chen, Yeming Wu, Zhixiang Wu   +5 more
doaj   +1 more source

Abstract 853: The biological role and mechanisms of XPO1 R749Q mutation in colon cancer

, 2022
Exportin-1 (XPO1) is known to be overexpressed or mutated in several cancer types. XPO1 is the target of selinexor, which has received approval in hematologic cancers but not in solid tumors. We recently performed a large-scale genomic analysis of 42,793
Chaudhry, Sana, Chojnacka, Monika, Afaghani, Jumana, Montoya, Skye, Totiger, Tulasigeri M., Affer, Maurizio, Taylor, Justin   +6 more
core   +1 more source