Results 1 to 10 of about 21,055 (183)

Exportin 1 modulates life span by regulating nucleolar dynamics via the autophagy protein LGG-1/GABARAP [PDF]

Science Advances, 2022
Altered nucleolar and ribosomal dynamics are key hallmarks of aging, but their regulation remains unclear. Building on the knowledge that the conserved nuclear export receptor Exportin 1 (XPO-1/XPO1) modulates proteostasis and life span, we systematically analyzed the impact of nuclear export on protein metabolism. Using transcriptomic and
Anita V. Kumar, Taewook Kang, Tara G. Thakurta, Celeste Ng, Aric N. Rogers, Martin R. Larsen, Louis R. Lapierre   +6 more
openaire   +4 more sources

The nuclear export protein exportin‐1 in solid malignant tumours: From biology to clinical trials

Clinical and Translational Medicine
Background Exportin‐1 (XPO1), a crucial protein regulating nuclear‐cytoplasmic transport, is frequently overexpressed in various cancers, driving tumor progression and drug resistance. This makes XPO1 an attractive therapeutic target.
Chuanxi Lai, Lingna Xu, Sheng Dai
doaj   +3 more sources

Exportin 1 (XPO1) Expression and Effectiveness of XPO1 Inhibitor Against Canine Lymphoma Cell Lines [PDF]

Veterinary Sciences
Lymphoma is the most common neoplasm of lymphoid tissues in dogs. Exportin 1 (XPO1) is an important major nuclear receptor for exporting proteins and RNA species.
Hardany Primarizky, Satoshi Kambayashi, Kenji Baba, Kenji Tani, Masaru Okuda   +4 more
doaj   +2 more sources

The nucleocytoplasmic translocation of HINT1 regulates the maturation of cell density [PDF]

Life Science Alliance
HINT1’s density-dependent shuttling regulates nuclear transcription at low density and cytoplasmic actin remodeling at high density. In normal epithelial cells on tissue culture dishes, contact inhibition typically progresses with a reduction in cell ...
Xiaofang Zhang, Fumihiko Nakamura
doaj   +2 more sources

Exportin 1 as a Therapeutic Target to Overcome Drug Resistance in Lung Cancer [PDF]

Cells
Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality, with therapeutic resistance continuing to limit long-term responses.
Maria Vittoria Di Marco, Alessandro Gasparetto, Roberto Chiarle, Claudia Voena   +3 more
doaj   +2 more sources

Selinexor Overcomes Hypoxia-Induced Drug Resistance in Multiple Myeloma [PDF]

Translational Oncology, 2017
Increased levels of the nuclear export protein, exportin 1 (XPO1), were demonstrated in multiple myeloma (MM) patients. Targeting XPO1 with selinexor (the selective inhibitor of nuclear export; SINE compound KPT-330) demonstrates broad antitumor activity
Barbara Muz, Feda Azab, Pilar de la Puente, Yosef Landesman, Abdel Kareem Azab   +4 more
doaj   +4 more sources

Paramyxovirus matrix protein redirects METTL3 for dual regulation of viral replication and immune evasion. [PDF]

PLoS Pathogens
N6-methyladenosine (m6A) epitranscriptomic modifications play crucial roles in regulating both host and viral gene expression. Here, we revealed a novel mechanism by which paramyxoviruses exploit host m6A machinery to simultaneously enhance viral ...
Takashi Okura, Yusuke Nakai, Taichi Kameya, Fuminori Mizukoshi, Hiyori Okura, Masatoshi Kakizaki, Fumihiro Kato, Yusuke Matsumoto, Yuichiro Nakatsu, Kaoru Takeuchi, Hirokazu Kimura, Makoto Takeda, Noriyuki Otsuki, Kazuya Shirato, Hideki Hasegawa, Akihide Ryo   +15 more
doaj   +2 more sources

Prognostic impact of biomarkers in PMBCL: rationale for early integration of immune checkpoint inhibitors [PDF]

Exploration of Targeted Anti-tumor Therapy
Aim: This research aims to guide future strategies for personalized treatment of primary mediastinal large B-cell lymphoma (PMBCL), particularly to identify high-risk patients who may benefit from incorporating immune checkpoint inhibitors (ICIs) in the ...
Yana K. Mangasarova, Runiza R. Abdurashidova, Natalya V. Risinskaya, Bella V. Biderman, Tatiana V. Abramova, Vadim L. Surin, Irina A. Shupletsova, Tatiana N. Obukhova, Rasul I. Iusupov, Yulia A. Chabaeva, Aminat U. Magomedova, Lena E. Nikulina, Sergei M. Kulikov, Eugene E. Zvonkov, Alla M. Kovrigina, Andrey B. Sudarikov   +15 more
doaj   +2 more sources

NRF2 activators and the inhibitor of nuclear export, selinexor, restrict coronaviruses by targeting a network involving ACE2, TMPRSS2, and XPO1 through an NRF2-independent mechanism [PDF]

Communications Biology
Nuclear factor erythroid 2–related factor 2 (NRF2) plays important roles in antiviral host cell defenses. We assessed the potential of the NRF2 activators 4-octyl itaconate (4OI), bardoxolone (BARD), and sulforaphane (SFN), and the exportin-1 (XPO1 ...
Fakhar H. Waqas, Leandro Silva da Costa, Francisco J. Zapatero-Belinchón, Madalina E. Carter-Timofte, Lisa Lasswitz, Demi van der Horst, Rebecca Möller, Julia Dahlmann, Ruth Olmer, Robert Geffers, Gisa Gerold, David Olagnier, Frank Pessler   +12 more
doaj   +2 more sources

Effects of cadmium on osteoblast cell line: Exportin 1 accumulation, p-JNK activation, DNA damage and cell apoptosis

Ecotoxicology and Environmental Safety, 2021
Cadmium is an environmental metal pollutant that has been a focus of research in recent years, which is reported to cause bone disease; however, its skeletal toxicity and the mechanism involved are not yet fully known. Therefore, this study used MC3T3-E1
Ling Ou, Haixia Wang, Zhidi Wu, Panpan Wang, Li Yang, Xiaoyun Li, Kehuan Sun, Xiaofeng Zhu, Ronghua Zhang   +8 more
doaj   +1 more source