Results 1 to 10 of about 32,019,221 (177)

Targeting nuclear export and Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) signalling in myelofibrosis: A novel combinatorial strategy that impacts intrinsic and microenvironment-related pathways. [PDF]

Br J Haematol
Selinexor targets molecular pathways critical to myelofibrosis (MF) progenitor cell fitness and demonstrates complementary activity with ruxolitinib, supporting its potential as a novel disease‐modifying therapeutic strategy for MF. Summary Myelofibrosis (MF) is a chronic myeloproliferative neoplasm (MPN) characterized by splenomegaly, constitutional ...
Kashyap T, Ellero AA, Walker CJ, Maloof ME, Lu M, Xia L, Hoffman R, Taverna P.   +7 more
europepmc   +2 more sources

Karyopherin Dysfunction Is a Key Driver of Aging. [PDF]

Aging Cell
Lapierre LR.
europepmc   +1 more source

XPO1: From basic research to clinical treatment (Review). [PDF]

Oncol Rep
Yang C, Zhu J, Zheng X, Hou X, Zhao J, Pan Y, Tang Y.   +6 more
europepmc   +1 more source

Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria-Induced Apoptosis Pathway. [PDF]

J Clin Lab Anal
Liu X, Huang L, Wang J, Guo Y, Shen H, Zhao X, Yue L, Liu Z, Fu R.   +8 more
europepmc   +1 more source

MicroRNA-425-3p: A Promising Biomarker and Candidate for Pharmacological Intervention in Neuropsychiatric Disabilities with Relevance to Major Depressive Disorder. [PDF]

Neuropsychiatr Dis Treat
May L, Dwivedi Y.
europepmc   +1 more source

Small RNAs, big impact: microRNAs in malaria pathogenesis, therapeutic opportunities, and challenges. [PDF]

Front Cell Infect Microbiol
Metwally NG, Tauler MDPM, Torabi H, Bruchhaus I.   +3 more
europepmc   +1 more source

Combination effect of Exportin 1 inhibitor (KPT-335) with doxorubicin or vincristine in canine lymphoma cell lines. [PDF]

J Vet Med Sci
Primarizky H, Kambayashi S, Baba K, Tani K, Okuda M.   +4 more
europepmc   +1 more source

Biochemical evaluation of Jihua hemostatic suppository in hemorrhagic internal hemorrhoids: Modulation of XPO1, VEGF, and collagen I/III expression and inflammatory biomarkers. [PDF]

J Med Biochem
Wang C, Kang Y, Wang Y, Liu Y, Shi M, Liu X, Jiao H.   +6 more
europepmc   +1 more source

Multiple roads between the nucleus and the cytoplasm: classes of linear NLSs and NESs and their receptors. [PDF]

Curr Opin Struct Biol
Wing CE, Chook YM.
europepmc   +1 more source

Curcumin pretreatment enhances the capacity of BMSC exosomes to attenuate renal ischemia-reperfusion injury by ferroptosis suppression via miR-16-5p/Smad3/Mb axis. [PDF]

Stem Cell Res Ther
Chen B, Chen J, Shen Z, Liu S, Mei Y, Cai H, Li K, Peng Z, Zhang L, Wang W, Lu S.   +10 more
europepmc   +1 more source