Exportin 1 as a Therapeutic Target to Overcome Drug Resistance in Lung Cancer [PDF]
CellsNon-small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality, with therapeutic resistance continuing to limit long-term responses.
Maria Vittoria Di Marco +3 more
doaj +2 more sources
Understanding Exportin-1 as an Anti-Cancer Target [PDF]
, 2018 Exportin-1 is a promising new anti-cancer target for selective inhibitors of nuclear export (SINE) molecules. Selinexor is a first-in-class SINE molecule in clinical trials for a variety of different cancers. Selinexor and other SINE molecules covalently
Burke, Russell Thomas
core +8 more sources
Paramyxovirus matrix protein redirects METTL3 for dual regulation of viral replication and immune evasion. [PDF]
PLoS PathogensN6-methyladenosine (m6A) epitranscriptomic modifications play crucial roles in regulating both host and viral gene expression. Here, we revealed a novel mechanism by which paramyxoviruses exploit host m6A machinery to simultaneously enhance viral ...
Takashi Okura +15 more
doaj +2 more sources
228 Verdinexor, an inhibitor of the nuclear export protein exportin-1 prevents lupus progression by limiting germinal center formation and development of autoreactive antibody secreting cells [PDF]
Abstracts, 2019 Background Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by simultaneous activation of the innate and adaptive arms of the immune system. Recently, the nuclear export protein exportin-1 (XPO1) has surfaced as an attractive target for the treatment of SLE. Selective Inhibitor of Nuclear Export (SINE) compounds such as
Javier Rangel-Moreno +5 more
openaire +3 more sources
Ecotoxicology and Environmental Safety, 2021 Cadmium is an environmental metal pollutant that has been a focus of research in recent years, which is reported to cause bone disease; however, its skeletal toxicity and the mechanism involved are not yet fully known. Therefore, this study used MC3T3-E1
Ling Ou +8 more
doaj +1 more source
A Competitive Binding Mechanism between Skp1 and Exportin 1 (CRM1) Controls the Localization of a Subset of F-box Proteins [PDF]
Journal of Biological Chemistry, 2011 SCF-type E3 ubiquitin ligases are crucial regulators of cell cycle progression. As the F-box protein is the substrate-specifying subunit of this family of ligases, their availability dictates the timing and the location of the ubiquitination of substrates.
David E, Nelson, Heike, Laman
openaire +2 more sources
Identification of a novel NPM1 mutation in acute myeloid leukemia
Experimental Hematology & Oncology, 2023 Nucleophosmin (NPM1) is a widely expressed nucleocytoplasmic shuttling protein with prominent nucleolar localization. It is estimated that 25–35% of adult patients with acute myeloid leukemia (AML) carry NPM1 mutations.
Yiyi Yao +6 more
doaj +1 more source
A Multifunctional Domain in Human CRM1 (Exportin 1) Mediates RanBP3 Binding and Multimerization of Human T-Cell Leukemia Virus Type 1 Rex Protein [PDF]
Molecular and Cellular Biology, 2003 Human CRM1 (hCRM1) functions in the Rex-mediated mRNA export of human T-cell leukemia virus type 1 (HTLV-1) as an export receptor and as an inducing factor for Rex multimerization on its cognate RNA. Although there are only 24 amino acid differences between hCRM1 and rat CRM1 (rCRM1), rCRM1 can hardly support Rex activity, suggesting a role for rCRM1 ...
Yoshiyuki, Hakata +2 more
openaire +2 more sources
Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1 [PDF]
Human Molecular Genetics, 2011 Polyglutamine (polyQ) diseases are a group of late-onset, progressive neurodegenerative disorders caused by CAG trinucleotide repeat expansion in the coding region of disease genes. The cell nucleus is an important site of pathology in polyQ diseases, and transcriptional dysregulation is one of the pathologic hallmarks observed.
Chan, Wing Man +9 more
openaire +4 more sources
Strength in Diversity: Nuclear Export of Viral RNAs
Viruses, 2020 The nuclear export of cellular mRNAs is a complex process that requires the orchestrated participation of many proteins that are recruited during the early steps of mRNA synthesis and processing.
Jón Pol Gales +3 more
doaj +1 more source