Results 41 to 50 of about 32,019,221 (177)

Nuclear Exportin 1 (XPO1) Binds to the Nuclear Localization/Export Signal of the Turnip Mosaic Virus NIb to Promote Viral Infection

Frontiers in Microbiology, 2022
The nuclear localization signal (NLS) and nuclear export signal (NES) are key signatures of proteins for controlling nuclear import and export. The NIb protein of turnip mosaic virus (TuMV) is an RNA-dependent RNA polymerase (RdRP) that is absolutely ...
Mingzhen Zhang, Pan Gong, Linhao Ge, Yinzi Li, Yinzi Li, Zhaoyang Chang, Rui Qiao, Xueping Zhou, Xueping Zhou, Aiming Wang, Aiming Wang, Fangfang Li   +11 more
doaj   +1 more source

Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington's disease

Neurobiology of Disease, 2013
Huntington's disease is characterized by the formation of protein aggregates, which can be degraded by macroautophagy. Here, we studied protein levels and intracellular distribution of p62 and NBR1, two macroautophagy cargo receptors, during disease ...
Laura Rué, Graciela López-Soop, Ellen Gelpi, Marta Martínez-Vicente, Jordi Alberch, Esther Pérez-Navarro   +5 more
doaj   +1 more source

Studying protein-protein interactions using peptide arrays [PDF]

, 2010
Screening of arrays and libraries of compounds is well-established as a high-throughput method for detecting and analyzing interactions in both biological and chemical systems. Arrays and libraries can be composed from various types of molecules, ranging
Rito, T., Rudiger, S.G.D., Sub Cellular Protein Chemistry, Rotem-Bamberger, S., Katz, C., Friedler, A., Levy-Beladev, L., Cellular Protein Chemistry   +7 more
core   +1 more source

Depletion of intracellular Ca2+ induces FOXM1 SUMOylation and accumulation on the inner nuclear membrane and accelerates G2/M cell cycle transition

European Journal of Cell Biology, 2023
Intracellular calcium (Ca2+) has been reported to regulate transcription factor activity and cancer development, but how it affects the function of Forkhead box protein M1 (FOXM1), a crucial transcription factor and key oncogene participating in ...
Tzu-Chien Lin, Ping-Jung Chung, Chen-An Shen, Thi My Hang Nguyen, Yi-Syuan Lin, Shih-Chieh Lin, Shih-Chuan Hsiao, Wen-Tai Chiu   +7 more
doaj   +1 more source

CHAPTER 1.1. Disulfide Bonds in Protein Folding and Stability [PDF]

, 2018
Disulfide bonds are unique among post-translational modifications, as they add covalent crosslinks to the polypeptide chain. Accordingly, they can exert pronounced effects on protein folding and stability. This is of particular importance for secreted or
Sub Cellular Protein Chemistry, Hendershot, Linda M., Feige, Matthias J., Ineke Braakman, Matthias J. Feige, Braakman, Ineke, Cellular Protein Chemistry, Linda M. Hendershot   +7 more
core   +1 more source

Pyramidalization of the Glycosidic Nitrogen Provides the Way for Efficient Cleavage of the N‑Glycosidic Bond of 8‑OxoG with the hOGG1 DNA Repair Protein [PDF]

, 2012
A mechanistic pathway for cleavage of the N-glycosidic bond of 8-oxo-2′-deoxyguanosine (oxoG) catalyzed with the human 8-oxoguanine glycosylase 1 DNA repair protein (hOGG1) is proposed in this theoretical study. The reaction scheme suggests direct proton
Sychrovský, V., Sub Cellular Protein Chemistry, Sebera, J., Tanaka, Y., Trantirek, L., Cellular Protein Chemistry   +5 more
core   +1 more source

Fission yeast Dicer harbours a unique dsRBD that participates in the spatial organization of the RNAi pathway [PDF]

, 2011
The term RNAi describes a set of conserved pathways found in most eukaryotes. RNAi is involved in various cellular processes, ranging from the control of gene expression to the establishment of heterochromatic structures.
Emmerth, Stephan
core   +1 more source

Immunoprecipitation of Tri-methylated Capped RNA

Bio-Protocol, 2018
Cellular quiescence (also known as G0 arrest) is characterized by reduced DNA replication, increased autophagy, and increased expression of cyclin-dependent kinase p27Kip1.
Karen Hayes, Jamie Barr, Mingyi Xie, Joan Steitz, Ivan Martinez   +4 more
doaj   +1 more source

Reversible disruption of XPO1-mediated nuclear export inhibits respiratory syncytial virus (RSV) replication

Scientific Reports, 2021
Respiratory syncytial virus (RSV) is the primary cause of serious lower respiratory tract disease in infants, young children, the elderly and immunocompromised individuals.
Cynthia Mathew, Sharon Tamir, Ralph A. Tripp, Reena Ghildyal   +3 more
doaj   +1 more source

Roles and Cellular Localization of GBP2 and NAB2 During the Blood Stage of Malaria Parasites

Frontiers in Cellular and Infection Microbiology, 2021
The quality control and export of mRNA by RNA-binding proteins are necessary for the survival of malaria parasites, which have complex life cycles. Nuclear poly(A) binding protein 2 (NAB2), THO complex subunit 4 (THO4), nucleolar protein 3 (NPL3), G ...
Mamoru Niikura, Toshiyuki Fukutomi, Jiro Mitobe, Fumie Kobayashi   +3 more
doaj   +1 more source