Results 51 to 60 of about 32,019,221 (177)

Hsp90 Breaks the Deadlock of the Hsp70 Chaperone System [PDF]

, 2018
Protein folding in the cell requires ATP-driven chaperone machines such as the conserved Hsp70 and Hsp90. It is enigmatic how these machines fold proteins.
Mayer, Matthias, Sub Cellular Protein Chemistry, Kityk, R., Rüdiger, S.G.D., Morán Luengo, T., Cellular Protein Chemistry   +5 more
core   +2 more sources

Give me a SINE: how Selective Inhibitors of Nuclear Export modulate autophagy and aging

Molecular & Cellular Oncology, 2018
Autophagy is a cellular recycling process leading to lysosomal degradation of damaged macromolecules, which can protect cells against aging. The transcription factor EB (TFEB), a major transcriptional regulator of genes involved in autophagy and ...
A.V. Kumar, T.G. Thakurta, M.J. Silvestrini, J.R. Johnson, R.A. Reenan, L.R. Lapierre   +5 more
doaj   +1 more source

Expressed protein ligation for a large dimeric protein [PDF]

, 2011
Expressed protein ligation (EPL) is a protein engineering tool for post-translational ligation of protein or peptide fragments. This technique allows modification of specific parts of proteins, opening possibilities for incorporating probes for ...
NMR Spectroscopy, Karagöz, G.E., Sub Cellular Protein Chemistry, O. Hsieh, Sub NMR Spectroscopy, T. Sinnige, Rüdiger, S.G.D., Hsieh, O., Sinnige, T, G. E. Karagoz, S. G. D. Rudiger, Cellular Protein Chemistry   +11 more
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Nuclear Pore Mechanotransduction in Oncology: A Structural Axis of Vulnerability for Targeted Intervention

Advanced Materials, EarlyView.
Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Yun Qian, Wei‐En Yuan, Victor Shahin   +5 more
wiley   +1 more source

Picky Hsp90-Every Game with Another Mate [PDF]

, 2017
In this issue of Molecular Cell, Sahasrabudhe et al. (2017) present a dramatically renovated functional cycle for the molecular chaperone Hsp90, which stimulates re-thinking of the mechanism of this vital protein folding ...
Sub Cellular Protein Chemistry, Rüdiger, Stefan G D, Radli, Martina, Cellular Protein Chemistry   +3 more
core   +2 more sources

Parental experiences orchestrate locust egg hatching synchrony by regulating nuclear export of precursor miRNA

Nature Communications
Parental experiences can affect the phenotypic plasticity of offspring. In locusts, the population density that adults experience regulates the number and hatching synchrony of their eggs, contributing to locust outbreaks.
Ya′nan Zhu, Jing He, Jiawen Wang, Wei Guo, Hongran Liu, Zhuoran Song, Le Kang   +6 more
doaj   +1 more source

Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response

Advanced Science, EarlyView.
This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du, Liping Wang, Sujing Diao, Juan Li, Lei Zhao, Yan Yan, Haimin Li, Weiren Dong, Wei Wu, Jinyan Gu, Jiyong Zhou   +10 more
wiley   +1 more source

Exportin 1 (Crm1p) Is an Essential Nuclear Export Factor [PDF]

, 1997
Nuclear protein export is mediated by nuclear export signals (NESs), but the mechanisms governing this transport process are not well understood. Using a novel protein export assay in S.
Ford, Charleen S., Guthrie, Christine, Stade, Katrin, Weis, Karsten   +3 more
core   +1 more source

Small-Molecule Antagonist Targeting Exportin‑1 via Rational Structure-Based Discovery

, 2020
Exportin-1 (also named as CRM1) plays a prominent role in autoimmune disorders and has emerged as a potential therapeutic target for colitis. Here we report on the rational structure-based discovery of a small-molecule antagonist of exportin-1, LFS-829 ...
Xiangyu Long, Huiying Chu (1964311), Jiali Gao (1334766), Xibao Tian (8693358), Minzhi Liang, Minzhi Liang (8693367), Qingxiang Sun (241307), Yongliang Yang, Huiying Chu, Xueliang Li, Guohui Li (105239), Fangjun Wang, Peng Chu, Jin Chen, Peng Chu (5565407), Cuixia Liu (4004888), Jiujiao Gao, Meishuo Liu (8693361), Xiangyu Long (172409), Cuixia Liu, Meishuo Liu, Fangjun Wang (1654270), Xueliang Li (585599), Guohui Li, Jiujiao Gao (597585), Yuqin Lei, Jiali Gao, Xibao Tian, Yongliang Yang (191550), Feida Long, Qingxiang Sun, Yuqin Lei (8693364), Jin Chen (130241), Feida Long (5565410)   +33 more
core   +2 more sources