Results 31 to 40 of about 32,019,221 (177)
Trypanosoma brucei RNA Binding Proteins p34 and p37 Mediate NOPP44/46 Cellular Localization via the Exportin 1 Nuclear Export Pathway [PDF]
Eukaryotic Cell, 2007 ABSTRACT We have previously identified and characterized two novel nuclear RNA binding proteins, p34 and p37, which have been shown to interact with a family of nucleolar phosphoproteins, NOPP44/46, in Trypanosoma brucei .
Kristina, Hellman +2 more
openaire +2 more sources
Nuclear export protein CSE1L interacts with P65 and promotes NSCLC growth via NF-κB/MAPK pathway
Molecular Therapy: Oncolytics, 2021 Non-small cell lung cancer (NSCLC) is characterized with high morbidity and mortality, mainly due to frequent recurrence and metastasis. However, the underlying molecular mechanisms of NSCLC tumorigenesis are largely unclear.
H.C. Lin +10 more
doaj +1 more source
The evolution of core proteins involved in microRNA biogenesis
BMC Evolutionary Biology, 2008 Background MicroRNAs (miRNAs) are a recently discovered class of non-coding RNAs (ncRNAs) which play important roles in eukaryotic gene regulation. miRNA biogenesis and activation is a complex process involving multiple protein catalysts and involves the
Brown James R +2 more
doaj +1 more source
PLoS Pathogens, 2018 Orientia tsutsugamushi causes scrub typhus, a potentially fatal infection that threatens over one billion people. Nuclear translocation of the transcription factor, NF-κB, is the central initiating cellular event in the antimicrobial response.
Sean M Evans +3 more
doaj +1 more source
Controlling protein transport by small molecules [PDF]
, 2011 Many proteins are transported from the nucleus to the cytoplasm by the exportin CRM1, which recognizes cargo proteins through a leucine rich nuclear export signal (NES).
Karl Gademann, Gademann, Karl
core +1 more source
Clinical and Translational Medicine, 2023 Background The majority of pancreatic ductal adenocarcinoma (PDAC) patients experience disease progression while on treatment with gemcitabine and nanoparticle albumin‐bound (nab)‐paclitaxel (GemPac) necessitating the need for a more effective treatment ...
Md. Hafiz Uddin +18 more
doaj +1 more source
Oncology Reports, 2014 The nuclear export receptor, Crm1 (exportin 1), is involved in the nuclear translocation of proteins and certain RNAs from the nucleus to the cytoplasm and is thus crucial for the correct localisation of cellular components. Crm1 has recently been reported to be highly expressed in certain types of cancers, yet its expression in oesophageal cancer has ...
Pauline J, van der Watt +5 more
openaire +3 more sources
Intramolecular quality control: HIV-1 envelope gp160 signal-peptide cleavage as a functional folding checkpoint [PDF]
, 2021 Removal of the membrane-tethering signal peptides that target secretory proteins to the endoplasmic reticulum is a prerequisite for proper folding.
Sub Cellular Protein Chemistry +10 more
core +2 more sources
PKCepsilon stimulated arginine methylation of RIP140 for its nuclear-cytoplasmic export in adipocyte differentiation. [PDF]
PLoS ONE, 2008 Receptor interacting protein 140 (RIP140) is a versatile transcriptional co-repressor that plays roles in diverse metabolic processes including fat accumulation in adipocytes.
Pawan Gupta +5 more
doaj +1 more source
The Arabidopsis thaliana F-box gene HAWAIIAN SKIRT is a new player in the microRNA pathway. [PDF]
PLoS ONE, 2017 In Arabidopsis, the F-box HAWAIIAN SKIRT (HWS) protein is important for organ growth. Loss of function of HWS exhibits pleiotropic phenotypes including sepal fusion.
Xuebin Zhang +6 more
doaj +1 more source