Results 61 to 70 of about 18,104 (240)

Structural basis for cooperativity of CRM1 export complex formation [PDF]

Proceedings of the National Academy of Sciences, 2012
In eukaryotes, the nucleocytoplasmic transport of macromolecules is mainly mediated by soluble nuclear transport receptors of the karyopherin-β superfamily termed importins and exportins. The highly versatile exportin chromosome region maintenance 1 (CRM1) is essential for nuclear depletion of numerous structurally and functionally ...
Monecke, T., Haselbach, D., Voß, B., Russek, A., Neumann, P., Thomson, E., Hurt, E., Zachariae, Ulrich, Stark, H., Grubmul̈ler, H., Dickmanns, A., Ficner, R.   +11 more
openaire   +6 more sources

Targeting nuclear transporters in cancer: Diagnostic, prognostic and therapeutic potential [PDF]

, 2016
The Karyopherin superfamily is a major class of soluble transport receptors consisting of both import and export proteins. The trafficking of proteins involved in transcription, cell signalling and cell cycle regulation among other functions across the ...
Aggarwal, Albee, Alnabulsi, Alshareeda, Altan, Angus, Behrens, Bernis, Blower, Brinkmann, Brinkmann, Cansizoglu, Chang, Christiansen, Dahl, Das, Dasso, Depping, Dikovskaya, Forbes, Gluz, Gontan, Gorlich, Gousias, Gousias, Gousias, Grupp, Gruss, Hashimoto, Hintersteiner, Hu, Huang, Huang, Huang, Hutchins, Hügel, Ishizawa, Jensen, Jiang, Kahle, Kau, Kazim, Kim, Kimura, King, Knauer, Kojima, Kosugi, Kudo, Kurisaki, Kutay, Kuusisto, Kuusisto, Lapalombella, Latvia, Lau, Laurila, Li, Liang, Liao, Lin, Lin, Lorenzato, Ma, Marfori, Martens-de Kemp, Melo, Mortezavi, Mosammaparast, Muller, Nevins, Noske, Parikh, Poon, Pumroy, Quan, Quensel, Rensen, Sakai, Scherf, Shen, Shi, Shiraki, Sillje, Smith, Smith, Soderholm, Song, Stawerski, Stella Tsai, Stewart, Tai, Torgerson, Turner, Turner, Wagstaff, Wang, Wang, Wang, Watt, Watt, Watt, Wellmann, Wiese, Winkler, Winnepenninckx, Wu, Yan, Yang, Yao, Yoshitake, Yu, Zender, Zheng, Zhou, Zhu, Zhu, Zienkiewicz   +117 more
core   +1 more source

CRM1- and Ran-independent nuclear export of β-catenin [PDF]

Current Biology, 2001
Activation of the Wnt pathway induces beta-catenin to localize inside the nucleus, where it interacts with transcription factors such as TCF/LEF-1. Regulation of the pathway occurs through a beta-catenin-degrading complex based on Axin and the tumor suppressor APC. We have previously found that beta-catenin import occurs independently of nuclear import
Wiechens, Nicola, Fagotto, François
openaire   +2 more sources

Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor

International Journal of Nanomedicine, 2021
Min Sui,1,* Meimei Xiong,2,* Yuling Li,1,* Qiao Zhou,1 Xiaofei Shen,3 Da Jia,3 Maling Gou,2 Qingxiang Sun1 1Department of Pathology and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Centre for ...
Sui M, Xiong M, Li Y, Zhou Q, Shen X, Jia D, Gou M, Sun Q   +7 more
doaj  

Exportins can inhibit major mitotic assembly events in vitro: membrane fusion, nuclear pore formation, and spindle assembly

Nucleus, 2020
Xenopus egg extracts are a powerful in vitro tool for studying complex biological processes, including nuclear reconstitution, nuclear membrane and pore assembly, and spindle assembly.
Matthew S. Nord, Cyril Bernis, Sarah Carmona, Dennis C. Garland, Anna Travesa, Douglass J. Forbes   +5 more
doaj   +1 more source

Chitosan‑based nanoparticles with damnacanthal suppress CRM1 expression

Oncology Letters, 2018
Cancer is one of the leading causes of mortality worldwide. Phytochemicals may be promising anticancer agents given their various chemical structures and diverse biological activities. Damnacanthal (DAM) is a major bioactive component of Noni, which has been investigated previously as a cancer-preventive or chemotherapeutic agent.
Chaichanasak, Nadda, Rojanapanthu, Pleumchitt, Yoon, Yongdae, Gritsanapan, Wandee, Chirachanchai, Suwabun, Sathirakul, Korbtham, Nualsanit, Thararat, Seong, Je Kyung, Baek, Seung Joon   +8 more
openaire   +3 more sources

Nucleolar Localization of HIV-1 Rev Is Required, Yet Insufficient for Production of Infectious Viral Particles. [PDF]

, 2018
Combination antiretroviral therapy fails in complete suppression of HIV-1 due to drug resistance and persistent latency. Novel therapeutic intervention requires knowledge of intracellular pathways responsible for viral replication, specifically those ...
Arizala, Jerlisa Ann C, Burnett, John C, Li, Haitang, Ouellet, Dominique L, Rossi, John J, Takahashi, Mayumi   +5 more
core   +1 more source

Pantothenate-encapsulated liposomes combined with exercise for effective inhibition of CRM1-mediated PKM2 translocation in Alzheimer's therapy.

Journal of Controlled Release
Alzheimer's disease (AD) is a complex neurodegenerative condition characterized by metabolic imbalances and neuroinflammation, posing a formidable challenge in medicine due to the lack of effective treatments.
Yisheng Chen, Lei Huang, Zhiwen Luo, Dan Han, Wei Luo, Renwen Wan, Yan Li, Yunshen Ge, Wei Lin, Yuchun Xie, Mingming Sun, Qian Wang, Zhiwei Li, Shiyi Chen, Yi Yang, Bin Huang, Yuzhen Xu   +16 more
semanticscholar   +1 more source

Back-spliced RNA from retrotransposon binds to centromere and regulates centromeric chromatin loops in maize.

PLoS Biology, 2020
In most plants, centromeric DNA contains highly repetitive sequences, including tandem repeats and retrotransposons; however, the roles of these sequences in the structure and function of the centromere are unclear.
Yalin Liu, Handong Su, Jing Zhang, Yang Liu, Chao Feng, Fangpu Han   +5 more
doaj   +1 more source

NESdb: a database of NES-containing CRM1 cargoes

Molecular Biology of the Cell, 2012
The leucine-rich nuclear export signal (NES) is the only known class of targeting signal that directs macromolecules out of the cell nucleus. NESs are short stretches of 8–15 amino acids with regularly spaced hydrophobic residues that bind the export karyopherin CRM1. NES-containing proteins are involved in numerous cellular and disease processes.
Xu, Darui, Grishin, Nick V., Chook, Yuh Min   +2 more
openaire   +2 more sources