Results 71 to 80 of about 7,200 (169)

Synergistic Antitumor Activity of HAT Inhibitor A485 and XPO1 Inhibitor KPT8602 in Multiple Myeloma

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Multiple myeloma (MM) remains the second most common hematologic malignancy, necessitating the identification of novel therapeutic targets. MM is characterized by a distinct epigenetic landscape driven by aberrant chromatin activation and super‐enhancer addiction.
Hong Xu, Wenqi Wu, Yanan Jiang, Jinhuan Wang, Yixin Zhai, Zhigang Zhao   +5 more
wiley   +1 more source

Correlation of CRM1-NES affinity with nuclear export activity

Molecular Biology of the Cell, 2018
CRM1 (Exportin1/XPO1) exports hundreds of broadly functioning protein cargoes out of the cell nucleus by binding to their classical nuclear export signals (NESs). The 8- to 15-amino-acid-long NESs contain four to five hydrophobic residues and are highly diverse in both sequence and CRM1-bound structure. Here we examine the relationship between nuclear
Fu, Szu-Chin, Fung, Ho Yee Joyce, Cağatay, Tolga, Baumhardt, Jordan, Chook, Yuh Min   +4 more
openaire   +2 more sources

Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria‐Induced Apoptosis Pathway

Journal of Clinical Laboratory Analysis, Volume 40, Issue 12, June 2026.
Inhibition of XPO1 is a promising modality in the treatment of MDS, especially when combined with Venetoclax, which activates mitochondria‐mediated apoptosis and could be a potential target for MDS therapy. ABSTRACT Background Myelodysplastic syndromes (MDS) are clonal hematopoietic malignancies that pose a serious health threat.
Xiaohan Liu, Lei Huang, Junzhu Wang, Yixuan Guo, Hongli Shen, Xianghong Zhao, Lanzhu Yue, Zhaoyun Liu, Rong Fu   +8 more
wiley   +1 more source

CRM1-Dependent Trafficking of Retroviral Gag Proteins Revisited [PDF]

Journal of Virology, 2012
ABSTRACT We analyzed the nuclear trafficking ability of Gag proteins from six retroviral genera. Contrary to a previous report, human immunodeficiency virus type 1 (HIV-1) Gag showed no propensity to cycle through the nucleus. The only Gag protein that displayed CRM1-dependent nuclear cycling was that of Rous sarcoma virus (RSV). Surprisingly,
Mariju F, Baluyot, Sarah A, Grosse, Terri D, Lyddon, Sanath K, Janaka, Marc C, Johnson   +4 more
openaire   +2 more sources

A Mechanosensitive Channel Governs Lipid Flippase-Mediated Echinocandin Resistance in Cryptococcus neoformans

mBio, 2019
Echinocandins show fungicidal activity against common invasive mycoses but are ineffective against cryptococcosis. The underlying mechanism for echinocandin resistance in Cryptococcus neoformans remains poorly understood but has been shown to involve ...
Chengjun Cao, Yina Wang, Seema Husain, Patricia Soteropoulos, Chaoyang Xue   +4 more
doaj   +1 more source

A genome‐integrated CRISPR/Cas12a system enables efficient genetic engineering in Xenorhabdus budapestensis XBD8

New Plant Protection, Volume 3, Issue 2, June 2026.
We developed a genome‐integrated CRISPR/Cas12a system for Xenorhabdus budapestensis XBD8, which enables precise deletion or replacement of DNA fragments ranging from 379 to 45,168 bp, with a success rate exceeding 90%. Application of this tool for the dynamic regulation of fabclavine‐8 biosynthesis resulted in a 1.90‐fold increase in production ...
Wenfeng Gan, Jiaqi Duan, Changyan Yin, Liwen Zhang, Guangyue Li   +4 more
wiley   +1 more source

Exploring Resistance to ETS Targeting Agents in Diffuse Large B‐Cell Lymphoma

Cancer Medicine, Volume 15, Issue 5, May 2026.
This study provides the first systematic characterization of resistance to ETS inhibition in diffuse large B‐cell lymphoma (DLBCL). Using TK216‐resistant models, we reveal heterogeneous escape mechanisms, including MDR1 upregulation, transcriptional reprogramming, and cytoskeletal remodeling, each associated with distinct mutational signatures ...
Filippo Spriano, Luciano Cascione, Chiara Tarantelli, Giulio Sartori, Alberto J. Arribas, Adriana Velasova, Sara Napoli, Ondrej Havranek, Jeffrey A. Toretsky, Francesco Bertoni   +9 more
wiley   +1 more source

Inhibition of CRM1 activity sensitizes endometrial and ovarian cell lines to TRAIL-induced cell death

Cell Communication and Signaling, 2018
Background CRM1 enrichment has been shown to be indicative of invasive as well as chemoresistant tumors. On the other hand, TRAIL, a powerful and specific anti-tumoral agent, has yet to be used effectively to treat gynecological tumors in patients.
François Fabi, Pascal Adam, Keven Vincent, Françis Demontigny, Sophie Parent, France-Hélène Joncas, Eric Asselin   +6 more
doaj   +1 more source

Targeting the nuclear export receptor exportin‐1 in acute myeloid leukaemia: From biology to clinical translation

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
• XPO1 hyperactivation promotes leukaemogenesis by altering nucleocytoplasmic transport and transcriptional control in acute myeloid leukaemia (AML). • Selinexor and eltanexor show preferential activity in NPM1‐mutated, DEK::NUP214‐positive and SF3B1‐mutated myeloid neoplasms.
Yifan Liu, Xiaoya Yun, Weidong Ding, Suxiao Li, Hui Liu   +4 more
wiley   +1 more source

Prognostic impact and targeting of CRM1 in acute myeloid leukemia

Blood, 2013
Key Points High CRM1 expression was associated with short survival of AML patients. CRM1 inhibitor KPT-185 induces apoptosis mainly in a p53-dependent manner, whereas inhibition of proliferation was p53 independent.
Kensuke, Kojima, Steven M, Kornblau, Vivian, Ruvolo, Archana, Dilip, Seshagiri, Duvvuri, R Eric, Davis, Min, Zhang, Zhiqiang, Wang, Kevin R, Coombes, Nianxiang, Zhang, Yi Hua, Qiu, Jared K, Burks, Hagop, Kantarjian, Sharon, Shacham, Michael, Kauffman, Michael, Andreeff   +15 more
openaire   +3 more sources