Results 71 to 80 of about 9,261 (202)

Give me a SINE: how Selective Inhibitors of Nuclear Export modulate autophagy and aging

Molecular & Cellular Oncology, 2018
Autophagy is a cellular recycling process leading to lysosomal degradation of damaged macromolecules, which can protect cells against aging. The transcription factor EB (TFEB), a major transcriptional regulator of genes involved in autophagy and ...
A.V. Kumar, T.G. Thakurta, M.J. Silvestrini, J.R. Johnson, R.A. Reenan, L.R. Lapierre   +5 more
doaj   +1 more source

The morphological affinities of the fossil cranium from Kabua, Kenya Affinités morphologiques du crâne fossile de Kabua (Kenya)

Journal of the Royal Anthropological Institute, EarlyView.
Our current understanding of the origins of Homo sapiens is limited, in part, by the fragmented fossil record from Late Pleistocene and early Holocene Africa. Here, we re‐examine the Kabua 1 cranium, an enigmatic and little‐studied Kenyan fossil discovered in the 1950s. We compare virtual reconstructions created previously by our team with a wide range
Abel Marinus Bosman, Laura Tabitha Buck, Hugo Reyes‐Centeno, Marta Mirazón Lahr, Chris Stringer, Rainer Grün, Qingfeng Shao, Katerina Harvati   +7 more
wiley   +1 more source

Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure

Cell Reports, 2023
Summary: NUP98 and NUP214 form chimeric fusion proteins that assemble into phase-separated nuclear bodies containing CRM1, a nuclear export receptor. However, these nuclear bodies’ function in controlling gene expression remains elusive.
Masahiro Oka, Mayumi Otani, Yoichi Miyamoto, Rieko Oshima, Jun Adachi, Takeshi Tomonaga, Munehiro Asally, Yuya Nagaoka, Kaori Tanaka, Atsushi Toyoda, Kazuki Ichikawa, Shinichi Morishita, Kyoichi Isono, Haruhiko Koseki, Ryuichiro Nakato, Yasuyuki Ohkawa, Yoshihiro Yoneda   +16 more
doaj   +1 more source

R‐Loops Mediated Odontogenic Differentiation of hDPSCs by Activating the cGAS‐STING Pathway Under Inflammatory Microenvironment

Oral Diseases, EarlyView.
ABSTRACT Background R‐Loops are three‐stranded DNA/RNA hybrids implicated in immune responses. Their role in mesenchymal stem cell differentiation, particularly in dental pulp regeneration under inflammation, remains unclear. Methods Rat pulpo‐dentinal complex (PDC) injury models and LPS‐stimulated human dental pulp stem cells (hDPSCs) were used.
Yun Yang, Yiqing Wang, Yating Miao, Zhipu Luo, Lin Niu, Ruirui Liu   +5 more
wiley   +1 more source

E2F4 Is Exported from the Nucleus in a CRM1-Dependent Manner [PDF]

Molecular and Cellular Biology, 2001
E2F is a family of transcription factors required for normal cell cycle control and for cell cycle arrest in G1. E2F4 is the most abundant E2F protein in many cell types. In quiescent cells, it is localized to the nucleus, where it is bound to the retinoblastoma-related protein p130.
S, Gaubatz, J A, Lees, G J, Lindeman, D M, Livingston   +3 more
openaire   +2 more sources

Distinct RanBP1 nuclear export and cargo dissociation mechanisms between fungi and animals

eLife, 2019
Ran binding protein 1 (RanBP1) is a cytoplasmic-enriched and nuclear-cytoplasmic shuttling protein, playing important roles in nuclear transport. Much of what we know about RanBP1 is learned from fungi. Intrigued by the long-standing paradox of harboring
Yuling Li, Jinhan Zhou, Sui Min, Yang Zhang, Yuqing Zhang, Qiao Zhou, Xiaofei Shen, Da Jia, Junhong Han, Qingxiang Sun   +9 more
doaj   +1 more source

Dynamics of nuclear export of pre-ribosomal subunits revealed by high-speed single-molecule microscopy in live cells

iScience, 2023
Summary: We present a study on the nuclear export efficiency and time of pre-ribosomal subunits in live mammalian cells, using high-speed single-molecule tracking and single-molecule fluorescence resonance energy transfer techniques.
Samuel L. Junod, Mark Tingey, Joseph M. Kelich, Alexander Goryaynov, Karl Herbine, Weidong Yang   +5 more
doaj   +1 more source

Expression characteristics of dual‐specificity phosphatase 2 and hypoxia‐inducible factor‐1α in acute kidney injury and preliminary study of the effect of dual‐specificity phosphatase 2 on HK‐2 cells

Experimental Physiology, EarlyView.
ABSTRACT Acute kidney injury (AKI) is a global health problem with significant long‐term harm if the prognosis is poor. Dual‐specificity phosphatase 2 (DUSP2) is involved in key regulatory pathways in several disease processes, but its function in renal pathophysiology is unclear.
Xueqian Chu, Songmin Xue, Lanyan Lin, Xuan Huang, Sisi Chen, Wulaer Adeli, Zulibiya Tuohetiyaer, Suhua Li, Chen Lu   +8 more
wiley   +1 more source

Targeting CRM1 for Progeria Syndrome Therapy

Aging Cell
ABSTRACTHutchinson‐Gilford progeria syndrome (HGPS) is a premature aging disease caused by progerin, a mutant variant of lamin A. Progerin anchors aberrantly to the nuclear envelope disrupting a plethora of cellular processes, which in turn elicits senescence.
Adriana Soto‐Ponce, Marlon De Ita, Susana Castro‐Obregón, Diego Cortez, Yosef Landesman, Jonathan J. Magaña, Susana Gonzalo, Tania Zavaleta, Angelica Soberano‐Nieto, Juan Unzueta, Isabel Arrieta‐Cruz, Porfirio Nava, Aurora Candelario‐Martínez, Ian García‐Aguirre, Bulmaro Cisneros   +14 more
openaire   +2 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, Volume 7, Issue 3, Page 109-124, September 2026.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source