Results 81 to 90 of about 18,104 (240)
Journal of Clinical Laboratory Analysis, EarlyView.Inhibition of XPO1 is a promising modality in the treatment of MDS, especially when combined with Venetoclax, which activates mitochondria‐mediated apoptosis and could be a potential target for MDS therapy. ABSTRACT Background Myelodysplastic syndromes (MDS) are clonal hematopoietic malignancies that pose a serious health threat.
Xiaohan Liu +8 more
wiley +1 more source
Give me a SINE: how Selective Inhibitors of Nuclear Export modulate autophagy and aging
Molecular & Cellular Oncology, 2018 Autophagy is a cellular recycling process leading to lysosomal degradation of damaged macromolecules, which can protect cells against aging. The transcription factor EB (TFEB), a major transcriptional regulator of genes involved in autophagy and ...
A.V. Kumar +5 more
doaj +1 more source
Das endogene Retrovirus HTDV/HERV-K: Untersuchungen zur Funktion des akzessorischen Proteins Rec [PDF]
, 2004 Retroviren benutzen für die Transkription und Translation ihrer Gene den zellulären Transkriptions und Translationsapparat. In eukaryotischen Zellen wird die RNA nach der Transkription prozessiert, erst danach verlässt sie den Kern.
Hahn, Silvia +1 more
core +1 more source
Journal of the Royal Anthropological Institute, EarlyView.Our current understanding of the origins of Homo sapiens is limited, in part, by the fragmented fossil record from Late Pleistocene and early Holocene Africa. Here, we re‐examine the Kabua 1 cranium, an enigmatic and little‐studied Kenyan fossil discovered in the 1950s. We compare virtual reconstructions created previously by our team with a wide range
Abel Marinus Bosman +7 more
wiley +1 more source
Potential effects of CRM1 inhibition in mantle cell lymphoma [PDF]
Chinese Journal of Cancer Research, 2012 Mantle cell lymphoma (MCL) is an aggressive histotype of B-cell non-Hodgkin lymphoma. The disease has no known cure, which prompts the urgent need for novel therapeutic agents. Chromosomal region maintenance 1 (CRM1) may play a role in human neoplasia and serve as a novel target of cancer treatment. This study summarizes MCL pathogenesis and determines
Zhang, Ke-Jie, Wang, Michael
openaire +3 more sources
The Irr1/Scc3 protein implicated in chromosome segregation in Saccharomyces cerevisiae has a dual nuclear-cytoplasmic localization [PDF]
, 2017 Background Correct chromosome segregation depends on the sister chromatid cohesion complex. The essential, evolutionarily conserved regulatory protein Irr1/Scc3, is responsible for the complex loading onto DNA and for its removal.
Fronk, Jan +2 more
core +2 more sources
Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1
Scientific Reports, 2018 TDP-43 and FUS are nuclear proteins with multiple functions in mRNA processing. They play key roles in ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia), where they are partially lost from the nucleus and aggregate in the cytoplasm of
H. Ederle +7 more
semanticscholar +1 more source
Experimental Physiology, EarlyView.ABSTRACT Acute kidney injury (AKI) is a global health problem with significant long‐term harm if the prognosis is poor. Dual‐specificity phosphatase 2 (DUSP2) is involved in key regulatory pathways in several disease processes, but its function in renal pathophysiology is unclear.
Xueqian Chu +8 more
wiley +1 more source
Crm1 locks up replication factors
The Journal of Cell Biology, 2003 ![Graphic][1] Crm1 in the cell cycle. Yamaguchi/Elsevier Limiting replication to a single round per division is critical for cells, but the proteins that control the process in metazoans have remained obscure.
openaire +2 more sources
iScience, 2023 Summary: We present a study on the nuclear export efficiency and time of pre-ribosomal subunits in live mammalian cells, using high-speed single-molecule tracking and single-molecule fluorescence resonance energy transfer techniques.
Samuel L. Junod +5 more
doaj +1 more source