Results 81 to 90 of about 9,261 (202)

The past, present, and future of CRM1/XPO1 inhibitors

Stem Cell Investigation, 2019
Therapies targeted at inhibiting nucleo-cytoplasmic transport have found broad applications in the field of oncology. Chromosome region maintenance 1 (CRM1), better known as exportin 1 (XPO1), is the protein transporter responsible for the nucleo-cytoplasmic shuttling of most of the tumor suppressor proteins (TSP) and growth regulatory factors. XPO1 is
Amy Y, Wang, Hongtao, Liu
openaire   +2 more sources

Repression of classical nuclear export by S-nitrosylation of CRM1 [PDF]

Journal of Cell Science, 2009
The karyopherin chromosomal region maintenance 1 (CRM1) is the major receptor for classical nuclear protein export. However, little is known about the regulation of CRM1 itself. Here, we report that cellular CRM1 became S-nitrosylated after extensive exposure to endogenous or exogenous nitric oxide (NO).
Peng, Wang, Guang-Hui, Liu, Kaiyuan, Wu, Jing, Qu, Bo, Huang, Xu, Zhang, Xixi, Zhou, Larry, Gerace, Chang, Chen   +8 more
openaire   +2 more sources

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning

eLife, 2015
CRM1 is a highly conserved, RanGTPase-driven exportin that carries proteins and RNPs from the nucleus to the cytoplasm. We now explored the cargo-spectrum of CRM1 in depth and identified surprisingly large numbers, namely >700 export substrates from ...
Koray Kırlı, Samir Karaca, Heinz Jürgen Dehne, Matthias Samwer, Kuan Ting Pan, Christof Lenz, Henning Urlaub, Dirk Görlich   +7 more
doaj   +1 more source

How Epitranscriptomic Machinery Senses Environmental Cues

Advanced Biology, Volume 10, Issue 9, September 2026.
Exogenous exposures, microenvironmental signals, and intracellular metabolic or redox states can alter RNA‐modification machinery through catalytic chemistry, signaling‐dependent PTMs, compartmental redistribution, or changes in abundance and composition.
Shayan Jalali, Ehsan Pashay Ahi
wiley   +1 more source

Analyse des CRM1- und Nup214- abhängigen Kernexportes von Proteinen

, 2012
Kernporenkomplexe sind sehr große Einheiten der Zellkernhülle, die den direktionalen Transport von Substraten in und aus dem Zellkern vermitteln. Besondere Proteine, Nukleoporine (Nups), stellen die Hauptkomponente dieses Komplexes dar.
Roloff, Stephanie
core   +1 more source

Chitosan‑based nanoparticles with damnacanthal suppress CRM1 expression

Oncology Letters, 2018
Cancer is one of the leading causes of mortality worldwide. Phytochemicals may be promising anticancer agents given their various chemical structures and diverse biological activities. Damnacanthal (DAM) is a major bioactive component of Noni, which has been investigated previously as a cancer-preventive or chemotherapeutic agent.
Chaichanasak, Nadda, Rojanapanthu, Pleumchitt, Yoon, Yongdae, Gritsanapan, Wandee, Chirachanchai, Suwabun, Sathirakul, Korbtham, Nualsanit, Thararat, Seong, Je Kyung, Baek, Seung Joon   +8 more
openaire   +3 more sources

Nucleocytoplasmic Traffic of CPEB1 and Accumulation in Crm1 Nucleolar Bodies [PDF]

Molecular Biology of the Cell, 2009
The translational regulator CPEB1 plays a major role in the control of maternal mRNA in oocytes, as well as of subsynaptic mRNAs in neurons. Although mainly cytoplasmic, we found that CPEB1 protein is continuously shuttling between nucleus and cytoplasm. Its export is controlled by two redundant NES motifs dependent on the nuclear export receptor Crm1.
Ernoult-Lange, Michèle, Wilczynska, Ania, Harper, Maryannick, Aigueperse, Christelle, Dautry, François, Kress, Michel, Weil, Dominique, Wickens, Marvin   +7 more
openaire   +2 more sources

Nuclear Export Signal Recognition by CRM1 Carrying the Oncogenic E571K Mutation and Structure-Based NES Prediction [PDF]

, 2022
Nuclear-cytoplasmic trafficking is an essential cellular process in eukaryotes that maintains and regulates the spatial distribution of key cellular processes in the nucleus and the cytoplasm.
Baumhardt, Jordan Matthew
core   +1 more source

The Cellular Distribution of RanGAP1 Is Regulated by CRM1-Mediated Nuclear Export in Mammalian Cells.

PLoS ONE, 2015
The Ran GTPase activating protein RanGAP1 plays an essential role in nuclear transport by stimulating RanGTP hydrolysis in the cytoplasmic compartment.
Keith Cha, Progga Sen, Sarita Raghunayakula, Xiang-Dong Zhang   +3 more
doaj   +1 more source

Mitochondria as the Hub of Apoptosis: A Comprehensive Insight From Mitochondria to Interactions With Other Organelles

MedComm, Volume 7, Issue 9, September 2026.
Mitochondria is the hub of apoptosis in various diseases. The disruption of mitochondrial structure (including membrane rupture, cristae remodeling, and mitochondrial membrane lipid redistribution), the imbalance of mitochondrial dynamics (including fusion and fission, autophagy), the release, disruption, and mutation of mitochondria DNA, as well as ...
Rubin Tan, Jinming Zhao, Rong Wang, Yue Shi, Zaozao Chen, Yixuan Ma, Na Li, Wenqing Duan, Duo Lin, Chunxiang Zhang   +9 more
wiley   +1 more source