Results 91 to 100 of about 9,261 (202)
Viruses, 2016 Influenza remains a serious worldwide public health problem. After infection, viral genomic RNA is replicated in the nucleus and packed into viral ribonucleoprotein, which will then be exported to the cytoplasm via a cellular chromosome region ...
Nopporn Chutiwitoonchai, Yoko Aida
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Geophysical Research Letters, Volume 53, Issue 16, 28 August 2026.Abstract Hydrothermal systems along the Mid‐Atlantic Ridge (MAR) are spatially variable sources of dissolved organic carbon (DOC) to the deep ocean, with implications for carbon cycling and trace‐metal transport. We present DOC measurements from four research cruises focusing on major vent fields at Menez Gwen, Rainbow, Lost City, Broken Spur and TAG ...
R. E. Tuerena +8 more
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Advanced Science, Volume 13, Issue 43, 3 August 2026.HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li +13 more
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Crm1 participates in the Rrp12-mediated 90S maturation step.
, 2014 (A) Northern blot analysis showing the amount of the indicated pre-RNA intermediaries and 5′-A0 byproduct (left) in control CRM1 and mutant crm1 (T539C) strains treated with leptomycin B (LMB) for the indicated periods of time (top).
Giulia Moriggi (669470) +2 more
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Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.Goniothalamin (GTN) exerts anticancer effects by promoting reactive oxygen species (ROS) generation, glutathione (GSH) depletion, DNA damage, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. These interconnected events trigger apoptosis, necroptosis, anoikis, and autophagy, while modulating mitogen‐activated protein kinase (MAPK ...
Nataša Joković +6 more
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Ratjadone and leptomycin B block CRM1-dependent nuclear export by identical mechanisms [PDF]
, 2004 Research on the export of proteins and nucleic acids from the nucleus to the cytoplasm has greatly gained from the discovery that the actinobacterial toxin leptomycin B (LMB) specifically inactivates the export receptor chromosomal region maintenance 1 ...
Krause, Eberhard +2 more
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Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.Studies have found that Jiuwei Xiaozhi Decoction can improve high‐fat diet‐induced fatty liver disease, mainly by regulating the SREBP2 and PPARα pathways to balance hepatic lipid metabolism while reducing inflammatory responses. ABSTRACT Jiuwei Xiaozhi Decoction (JWXZ) is a nine‐herb traditional Chinese medicine formula clinically used for hepatic ...
Youcheng Ma +5 more
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TChal regulates the translocation of p53 via CRM1 downregulation.
, 2018 A. Free-magnetic beads or beads bound with TChal were obtained as described in the Materials and Methods section, and incubated overnight at 4 °C with cell lysates from U2OS cells overexpressing CRM1.
Nadda Chaichanasak (5641775) +13 more
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mBio, 2019 Echinocandins show fungicidal activity against common invasive mycoses but are ineffective against cryptococcosis. The underlying mechanism for echinocandin resistance in Cryptococcus neoformans remains poorly understood but has been shown to involve ...
Chengjun Cao +4 more
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Binding of NP-NES3 mutant proteins to CRM1.
, 2014 (A) FLAG-tagged NP-NES3 wild-type and mutant (Φ1, Φ2, Φ3, and Φ4) proteins were prepared by transfecting the relevant pCAGGS plasmids into HEK-293T cells. The cells were then lysed.
Kazunori Yamada (286428) +3 more
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