Results 91 to 100 of about 18,104 (240)

eEF1A mediates the nuclear export of SNAG-containing proteins via the exportin5-aminoacyl-tRNA complex [PDF]

, 2015
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License.Exportin5 mediates the nuclear export of double-stranded RNAs, including pre-microRNAs, adenoviral RNAs, and tRNAs ...
Cano, Amparo, Mingot, José Manuel, Nieto, M. Ángela, Portillo, Francisco, Vega, Sonia   +4 more
core   +1 more source

Distinct RanBP1 nuclear export and cargo dissociation mechanisms between fungi and animals

eLife, 2019
Ran binding protein 1 (RanBP1) is a cytoplasmic-enriched and nuclear-cytoplasmic shuttling protein, playing important roles in nuclear transport. Much of what we know about RanBP1 is learned from fungi. Intrigued by the long-standing paradox of harboring
Yuling Li, Jinhan Zhou, Sui Min, Yang Zhang, Yuqing Zhang, Qiao Zhou, Xiaofei Shen, Da Jia, Junhong Han, Qingxiang Sun   +9 more
doaj   +1 more source

Selinexor overcomes hypoxia-induced drug resistance in multiple myeloma [PDF]

, 2017
Increased levels of the nuclear export protein, exportin 1 (XPO1), were demonstrated in multiple myeloma (MM) patients. Targeting XPO1 with selinexor (the selective inhibitor of nuclear export; SINE compound KPT-330) demonstrates broad antitumor activity
Azab, Abdel Kareem, Azab, Feda, de la Puente, Pilar, Landesman, Yosef, Muz, Barbara   +4 more
core   +3 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, Volume 20, Issue 3, Page 727-752, March 2026.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

CRM1/BIG-Mediated Auxin Action Regulates Arabidopsis Inflorescence Development [PDF]

Plant and Cell Physiology, 2007
The shape of the inflorescence in Arabidopsis thaliana ecotype Columbia is a raceme with individual flowers developing acropetally. The ecotype Landsberg harboring the erecta (er) mutation shows a corymb-like inflorescence, namely a compact inflorescence with a flattened arrangement of flower buds at the tip.
Nobutoshi, Yamaguchi, Mitsuhiro, Suzuki, Hidehiro, Fukaki, Miyo, Morita-Terao, Masao, Tasaka, Yoshibumi, Komeda   +5 more
openaire   +2 more sources

XPO1 inhibition by selinexor induces potent cytotoxicity against high grade bladder malignancies. [PDF]

, 2018
Treatment options for high grade urothelial cancers are limited and have remained largely unchanged for several decades. Selinexor (KPT-330), a first in class small molecule that inhibits the nuclear export protein XPO1, has shown efficacy as a single ...
Baek, Han Bit, Fernandez-Rubio, Aleida, Gandour-Edwards, Regina, Ghosh, Paramita M, Landesman, Yosef, Libertini, Stephen J, Lombard, Alan P, Mudryj, Maria, Nakagawa, Rachel, Nishida, Kristine, Siddiqui, Salma, Vidallo, Kathleen, Vinall, Ruth, Weiss, Robert H, Wettersten, Hiromi   +14 more
core   +1 more source

Evolution of H5N1 Cross‐Species Transmission: Adaptive Mutations Driving Avian‐to‐Human Infection

Advanced Genetics, Volume 7, Issue 1, March 2026.
This review synthesizes current knowledge on the molecular mechanisms underpinning H5N1's host adaptation, focusing on key mutations in viral proteins. Critical mutations are discussed in detail, highlighting their roles in altering receptor specificity, promoting antiviral resistance, and expanding viral tropism. The review underscores the urgent need
Wenxin Man, Lin Du, Ying Liu, Zehan Pang, Hongyan Zhu, Bixia Hong, Zhichao Xu, Huahao Fan   +7 more
wiley   +1 more source

NXT1, a Novel Influenza A NP Binding Protein, Promotes the Nuclear Export of NP via a CRM1-Dependent Pathway

Viruses, 2016
Influenza remains a serious worldwide public health problem. After infection, viral genomic RNA is replicated in the nucleus and packed into viral ribonucleoprotein, which will then be exported to the cytoplasm via a cellular chromosome region ...
Nopporn Chutiwitoonchai, Yoko Aida
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, Volume 600, Issue 3, Page 370-382, February 2026.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning

eLife, 2015
CRM1 is a highly conserved, RanGTPase-driven exportin that carries proteins and RNPs from the nucleus to the cytoplasm. We now explored the cargo-spectrum of CRM1 in depth and identified surprisingly large numbers, namely >700 export substrates from ...
Koray Kırlı, Samir Karaca, Heinz Jürgen Dehne, Matthias Samwer, Kuan Ting Pan, Christof Lenz, Henning Urlaub, Dirk Görlich   +7 more
doaj   +1 more source