Results 111 to 120 of about 18,104 (240)
Leptomycin B alters the subcellular distribution of CRM1 (Exportin 1) [PDF]
Biochemical and Biophysical Research Communications, 2017 CRM1 (chromosome maintenance region 1, Exportin 1) binds to nuclear export signals and is required for nucleocytoplasmic transport of a large variety of proteins and RNP complexes. Leptomycin B (LMB), the first specific inhibitor of CRM1 identified, binds covalently to cysteine 528 in the nuclear export signal binding region of CRM1 leading to the ...
Khatera, Rahmani, David A, Dean
openaire +2 more sources
Journal of Cell Science, 2019 Hypoxia-inducible factor 2 (HIF-2) is a principal component of the cellular response to oxygen deprivation (hypoxia). Its inducible subunit, HIF-2α (also known as EPAS1), is controlled by oxygen-dependent as well as oxygen-independent mechanisms, such as
Ioanna-Maria Gkotinakou +3 more
semanticscholar +1 more source
Dualistic Roles of High Mobility Group Box 1 in Cancer and Inflammation
Cancer Medicine, Volume 14, Issue 23, December 2025.ABSTRACT Background The High Mobility Group Box 1 (HMGB1) protein, a member of the HMG family, plays a crucial role in both cancer progression and inflammatory responses. HMGB1 can act as a damage‐associated molecular pattern (DAMP) to activate immune responses and modulate inflammation.
Wen Zeng +6 more
wiley +1 more source
370. CRM1 Enhances the Lentiviral Vector Production
Molecular Therapy, 2006 Lentiviral vectors derived from human immunodeficiency virus 1 (HIV-1) are increasingly used in the delivery of transgenes into mammalian cells for gene function studies and for potential treatment of human diseases. One of the major barriers of applying HIV vector in disease treatment is to provide sufficient amounts of infectious vectors at high ...
Lo, Hsin-Lung +5 more
openaire +1 more source
mBio, 2019 Echinocandins show fungicidal activity against common invasive mycoses but are ineffective against cryptococcosis. The underlying mechanism for echinocandin resistance in Cryptococcus neoformans remains poorly understood but has been shown to involve ...
Chengjun Cao +4 more
doaj +1 more source
Evolutionarily Conserved Sequence Features Regulate the Formation of the FG Network at the Center of the Nuclear Pore Complex. [PDF]
, 2015 The nuclear pore complex (NPC) is the portal for bidirectional transportation of cargos between the nucleus and the cytoplasm. While most of the structural elements of the NPC, i.e.
Lee, BL +3 more
core +2 more sources
Protein O‐GlcNAcylation in Health and Diseases
MedComm, Volume 6, Issue 12, December 2025.We first introduced the beneficial effects of normal protein O‐GlcNAcylation on health, impacting biological processes such as gene expression, cell cycle progression, metabolism, and signal transduction. Next, we described the role of abnormal protein O‐GlcNAcylation in the development and progression of diseases, including neurodegenerative diseases,
Zhihong Ran +5 more
wiley +1 more source
Advanced Science, Volume 12, Issue 41, November 6, 2025.This study uncovers a novel mechanism in which p300‑catalyzed lactylation of HMGB1 triggers nuclear export of the HMGB1‐TIAR complex, driving TIAR‐dependent SGs formation in the cytoplasm. Mass spectrometry and mutagenesis reveals that K177 lactylation is essential for this export and subsequent SGs formation.
Chengyu Li +8 more
wiley +1 more source
Cell Communication and Signaling, 2018 Background CRM1 enrichment has been shown to be indicative of invasive as well as chemoresistant tumors. On the other hand, TRAIL, a powerful and specific anti-tumoral agent, has yet to be used effectively to treat gynecological tumors in patients.
François Fabi +6 more
doaj +1 more source
eLife, 2020 In the nucleus, the spatiotemporal regulation of the catalytic subunit of cAMP-dependent protein kinase A (PKA-C) is orchestrated by an intrinsically disordered protein kinase inhibitor, PKI, which recruits the CRM1/RanGTP nuclear exporting complex.
Cristina Olivieri +13 more
doaj +1 more source