Results 111 to 120 of about 9,261 (202)
PLoS Pathogens, 2011 The human immunodeficiency virus type-1 (HIV-1) Rev protein regulates the nuclear export of intron-containing viral RNAs by recruiting the CRM1 nuclear export receptor.
Nathan M Sherer +5 more
doaj +1 more source
Expression of exportin 1 (XPO1/CRM1) in pancreatic adenocarcinoma.
, 2017 327 Background: Exportin 1 (XPO1/CRM1) is a nuclear export chaperone that mediates the nuclear export of several proteins that are essential to growth regulation and tumor suppression.
David M Saulino +3 more
core +1 more source
Compilation of bonding interactions among three chosen phytochemicals and CRM1.
, 2023 Compilation of bonding interactions among three chosen phytochemicals and CRM1.
Mohammad Habibur Rahman Molla (13902168) +13 more
core +1 more source
Correlation of CRM1-NES affinity with nuclear export activity
Molecular Biology of the Cell, 2018 CRM1 (Exportin1/XPO1) exports hundreds of broadly functioning protein cargoes out of the cell nucleus by binding to their classical nuclear export signals (NESs). The 8- to 15-amino-acid-long NESs contain four to five hydrophobic residues and are highly diverse in both sequence and CRM1-bound structure. Here we examine the relationship between nuclear
Fu, Szu-Chin +4 more
openaire +2 more sources
eLife, 2018 Non-centrosomal microtubule organizing centers (MTOCs) are important for microtubule organization in many cell types. In fission yeast Schizosaccharomyces pombe, the protein Mto1, together with partner protein Mto2 (Mto1/2 complex), recruits the γ ...
Xun X Bao +7 more
doaj +1 more source
Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importin ?1 and CRM1 [PDF]
, 2009 [[abstract]]Many receptor tyrosine kinases (RTKs) can be detected in the cell nucleus, such as EGFR, HER-2, HER-3, HER-4, and fibroblast growth factor receptor.
Lo, H-W.;Seyed-Mohamed, A.;Wu, Y.;Bartholomeusz, G.;Hsu, S-C.;Mien-Chie Hung
core
Viruses with pharmacologic evidence of XPO1 (CRM1)-dependence.
, 2023 Viruses with pharmacologic evidence of XPO1 (CRM1)-dependence.
Mahmoud Shehata (9574695) +17 more
core +1 more source
PLoS ONE, 2013 Influenza continues to pose a threat to humans by causing significant morbidity and mortality. Thus, it is imperative to investigate mechanisms by which influenza virus manipulates the function of host factors and cellular signal pathways. In this study,
Young-Jin Seo +6 more
doaj +1 more source
Nullbasic-induced redistribution of Rev is CRM1 dependent.
, 2012 HeLa cells were transfected to express Myc-Rev alone (rows 2 and 3), Nullbasic (NB)-mCherry alone (row 4) or Myc-Rev with NB-mCherry (rows 5 and 6) before being treated with (rows 3 and 6) or without (rows 1, 2, 4 and 6) leptomycin B (LMB) in order to ...
Min-Hsuan Lin (113008) +5 more
core +1 more source
Prognostic impact and targeting of CRM1 in acute myeloid leukemia
Blood, 2013 Key Points High CRM1 expression was associated with short survival of AML patients. CRM1 inhibitor KPT-185 induces apoptosis mainly in a p53-dependent manner, whereas inhibition of proliferation was p53 independent.
Kensuke, Kojima +15 more
openaire +3 more sources