Results 131 to 140 of about 9,261 (202)

Inter-cellular transport of ran GTPase.

PLoS ONE, 2015
Ran, a member of the Ras-GTPase superfamily, has a well-established role in regulating the transport of macromolecules across the nuclear envelope (NE). Ran has also been implicated in mitosis, cell cycle progression, and NE formation. Over-expression of
Deepak Khuperkar, Mary Helen, Indrasen Magre, Jomon Joseph   +3 more
doaj   +1 more source

Abstract 1799: CRM1 expression in pancreatic adenocarcinoma correlates with survivin expression and the proliferative activity

, 2017
Introduction: CRM1 is a nuclear export chaperone that mediates the export of proteins essential to growth regulation and tumor suppression. Its overexpression in tumors was found to be associated with poor prognosis.
Pamela S. Younes, Jennifer M. Bailey, Mamoun Younes, David M. Saulino   +3 more
core   +1 more source

The Anti-inflammatory Prostaglandin 15-Deoxy-Delta(12,14)-PGJ(2) Inhibits CRM1-dependent Nuclear Protein Export

, 2010
The signaling molecule 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) has been described as the "anti-inflammatory prostaglandin." Here we show that substrates of the nuclear export receptor CRM1 accumulate in the nucleus in the presence of 15d ...
Marcone, Simone, Frohnert, Cornelia, Fitzgerald, Desmond J., Nath, Annegret, Hilliard, Mark, Spillner, Christiane, Kehlenbach, Ralph H., Lampe, Tina   +7 more
core   +1 more source

Hydrophobic residues for PKI NES optimal binding to CRM1.

, 2019
Hydrophobic residues for PKI NES optimal binding to CRM1.
Claude Marchand (7300472), Denis Archambault (7300475), Guy Lemay (3106380)   +2 more
core   +1 more source

Nuclear Export Signal Recognition by CRM1 Carrying the Oncogenic E571K Mutation and Structure-Based NES Prediction

, 2020
Nuclear-cytoplasmic trafficking is an essential cellular process in eukaryotes that maintains and regulates the spatial distribution of key cellular processes in the nucleus and the cytoplasm.
Baumhardt, Jordan Matthew
core   +1 more source

The nucleoporin Nup214 sequesters CRM1 at the nuclear rim and modulates NFkappaB activation in Drosophila

, 2006
CRM1-mediated protein export is an important determinant of the nuclear accumulation of many gene regulators. Here, we show that the NFkappaB transcription factor Dorsal is a substrate of CRM1 and requires the nucleoporin Nup214 for its nuclear ...
Vasilios Tsarouhas, Sabri, Nafiseh,, Tsarouhas, Vasilios, Nikos Xylourgidis, Roth, Peggy, Christos Samakovlis, Nafiseh Sabri, Samakovlis, Christos, Xylourgidis, Nikos, Peggy Roth   +9 more
core   +1 more source

CRM1-Dependent Cytoplasmic Accumulation of TRIM27 Is Associated with Glomerular Endothelial Cell Injury in Lupus Nephritis. [PDF]

Cells
Cui H, Feng X, Tian Y, Miao X, Xing L, Wang X, Tian Y, Liu Q, Zhang W, Liu J, Liu S.   +10 more
europepmc   +1 more source

The molecular mechanism underlying the differential subcellular distribution of dystrophin Dp71 isoforms. [PDF]

Cell Biosci
Alamillo-Iniesta A, Velez-Aguilera G, Monterrubio-Ledezma F, Ávila-Avilés RD, Suárez-Sánchez R, García-Aguirre I, Lizcano-Meneses S, López-Orona TI, Guevara-Namorado F, Toribio-Valdez A, Hernández-Hernández JM, Arrieta-Cruz I, Magaña JJ, Cisneros B.   +13 more
europepmc   +1 more source

CRM1

Seibutsu Butsuri, 2015
openaire   +2 more sources

A Unified Model: Chromatin-Bound Multicomponent Condensates. [PDF]

Cancer Res
Lau BK, Haarer EL, Ahn JH, Wang GG.
europepmc   +1 more source