Results 131 to 140 of about 7,200 (169)

BCAS2 promotes primitive hematopoiesis by sequestering β-catenin within the nucleus. [PDF]

Elife
Ning G, Lin Y, Ma H, Zhang J, Yang L, Liu Z, Li L, He X, Wang Q.   +8 more
europepmc   +1 more source

Arsenic-Induced PPARγ, with the Coordinated Action of p62, Inhibits Apoptosis and Necroptosis and Activates the DNA Damage Response in A549 Lung Cancer Cells, Leading to Carcinogenesis. [PDF]

Cells
Kim HR, Oh SH.
europepmc   +1 more source

Virus and cell specific HMGB1 secretion and subepithelial infiltrate formation in adenovirus keratitis. [PDF]

PLoS Pathog
Saha A, Islam MM, Kumar R, Ismail AM, Garcia E, Gullapali RR, Chodosh J, Rajaiya J.   +7 more
europepmc   +1 more source

Strategies for the Viral Exploitation of Nuclear Pore Transport Pathways. [PDF]

Viruses
Zhang X, Lim K, Qiu Y, Hazawa M, Wong RW.   +4 more
europepmc   +1 more source

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CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity

Blood, 2011
Abstract CRM1 plays an important role in the nuclear export of cargo proteins bearing nuclear exporting signal sequences. Leptomycin B (LMB), a well-known CRM1 inhibitor, possesses strong antitumor properties. However, its toxicity prevents it from being clinically useful.
Keiichi, Sakakibara, Naoya, Saito, Takuji, Sato, Atsushi, Suzuki, Yoko, Hasegawa, Jonathan M, Friedman, Donald W, Kufe, Daniel D, Vonhoff, Tadahiko, Iwami, Takumi, Kawabe   +9 more
openaire   +3 more sources

Domains of Crm1 Involved in the Formation of the Crm1, RanGTP, and Leucine-Rich Nuclear Export Sequences Trimeric Complex

Experimental Cell Research, 1999
Nuclear export of proteins containing a leucine-rich nuclear export sequence (NES) is mediated by a specific NES receptor known as Crm1. This protein, which is related to the karyopherin beta family, interacts directly with NES in a RanGTP-dependent manner.
B, Ossareh-Nazari, C, Dargemont
exaly   +3 more sources

Cellular Requirements for CRM1 Import and Export

Journal of Biochemistry, 2003
We studied the cellular requirements for the translocation of CRM1 (exportin 1) between the nucleus and the cytoplasm. CRM1 import requires neither ATP, Ran, Ran-dependent GTP hydrolysis, nor a particular temperature. CRM1 and importin beta compete with each other during their import.
Xianfeng, Zhang, Masami, Yamada, Naoto, Mabuchi, Hisatoshi, Shida   +3 more
openaire   +2 more sources

CRM1 expression in pancreatic carcinoma.

Journal of Clinical Oncology, 2013
e15115 Background: Increased expression of chromosomal region maintenance (CRM1) protein, also known as exportin 1, has been described in several human cancers. It is an important regulator of subcellular localization of tumor suppressor proteins and growth regulatory proteins. Direct inhibition of CRM1 blocks cell proliferation and induces apoptosis
Amit Mahipal, Domenico Coppola, Shilpa Gupta, Barbara Centeno, Mokenge Peter Malafa   +4 more
openaire   +1 more source

CRM1-mediated nuclear export: to the pore and beyond

Trends in Cell Biology, 2007
CRM1 (chromosome region maintenance 1; also referred to as exportin1 or Xpo1) is a member of the importin beta superfamily of nuclear transport receptors, recognizing proteins bearing a leucine-rich nuclear export sequence. CRM1 is the major receptor for the export of proteins out of the nucleus and is also required for transport of many RNAs.
Saskia, Hutten, Ralph H, Kehlenbach
openaire   +2 more sources