Results 131 to 140 of about 18,104 (240)

Unveiling the Role of circRNAs in Pyroptotic Signalling: From Molecular Crosstalk to Disease Modulation

Journal of Cellular and Molecular Medicine, Volume 29, Issue 22, November 2025.
ABSTRACT Pyroptosis is a gasdermins‐dependent programmed cell death (PCD) characterised by progressive cellular swelling and plasma membrane rupture (PMR). This process releases intracellular contents that amplify inflammatory cascades and immune activation, involving the pathogenesis of various disorders such as tumours, heart and vascular diseases ...
Tengyu Jin, Guodong Xu, Wanru Zhou, Yige Shi, Hebo Wang   +4 more
wiley   +1 more source

Evolution of a species-specific determinant within human CRM1 that regulates the post-transcriptional phases of HIV-1 replication.

PLoS Pathogens, 2011
The human immunodeficiency virus type-1 (HIV-1) Rev protein regulates the nuclear export of intron-containing viral RNAs by recruiting the CRM1 nuclear export receptor.
Nathan M Sherer, Chad M Swanson, Stéphane Hué, Roland G Roberts, Julien R C Bergeron, Michael H Malim   +5 more
doaj   +1 more source

Posttranscriptional regulation of PARG mRNA by HuR facilitates DNA repair and resistance to PARP inhibitors [PDF]

, 2017
The majority of pancreatic ductal adenocarcinomas (PDAC) rely on the mRNA stability factor HuR (ELAV-L1) to drive cancer growth and progression. Here, we show that CRISPR-Cas9–mediated silencing of the HuR locus increases the relative sensitivity of PDAC
Brody, Jonathan R., Chand, Saswati N., Cozzitorto, Joseph A., Jiang, Wei, Knudsen, Karen E., Lal, Shruti, Londin, Eric R., Meisner-Kober, Nicole, Nevler, Avinoam, Pascal, John M, Pishvaian, Michael J., Romeo, Carmella, Sanan, Akshay R., Schiewer, M. J., Scolaro, Laura, Winter, Jordan M., Yeo, Charles, Zarei, Mahsa   +17 more
core   +1 more source

ANP32A and ANP32B are key factors in the Rev-dependent CRM1 pathway for nuclear export of HIV-1 unspliced mRNA

Journal of Biological Chemistry, 2019
The nuclear export receptor CRM1 is an important regulator involved in the shuttling of various cellular and viral RNAs between the nucleus and the cytoplasm.
Yujie Wang, Haili Zhang, Lei Na, Cheng Du, Zhenyu Zhang, Yong-Hui Zheng, Xiaojun Wang   +6 more
semanticscholar   +1 more source

CRM1/XPO1 is associated with clinical outcome in glioma and represents a therapeutic target by perturbing multiple core pathways

Journal of Hematology & Oncology, 2016
Background Malignant gliomas are associated with a high mortality rate, and effective treatment options are limited. Thus, the development of novel targeted treatments to battle this deadly disease is imperative.
Xuejiao Liu, Yulong Chong, Yiming Tu, Ning Liu, Chenglong Yue, Zhenglei Qi, Huize Liu, Yao Yao, Hongmei Liu, Shangfeng Gao, Mingshan Niu, Rutong Yu   +11 more
doaj   +1 more source

Identification of a Small Molecule Inhibitor of Importin β Mediated Nuclear Import by Confocal On-Bead Screening of Tagged One-Bead One-Compound Libraries [PDF]

, 2010
In eukaryotic cells, proteins and RNAs are transported between the nucleus and the cytoplasm by nuclear import and export receptors. Over the past decade, small molecules that inhibit the nuclear export receptor CRM1 have been identified, most notably ...
Ambrus, Geza, Auer, Manfred, Bednenko, Janna, Gerace, Larry, Gstach, Hubert, Hintersteiner, Martin, Knox, Andrew J. S., Meisner, Nicole-Claudia, Schmied, Mario, Seifert, Jan-Marcus, Singer, Eric L.   +10 more
core   +1 more source

Exportin Crm1 is repurposed as a docking protein to generate microtubule organizing centers at the nuclear pore

eLife, 2018
Non-centrosomal microtubule organizing centers (MTOCs) are important for microtubule organization in many cell types. In fission yeast Schizosaccharomyces pombe, the protein Mto1, together with partner protein Mto2 (Mto1/2 complex), recruits the γ ...
Xun X Bao, Christos Spanos, Tomoko Kojidani, Eric M Lynch, Juri Rappsilber, Yasushi Hiraoka, Tokuko Haraguchi, Kenneth E Sawin   +7 more
doaj   +1 more source

Exo70-Mediated Recruitment of Nucleoporin Nup62 at the Leading Edge of Migrating Cells is Required for Cell Migration [PDF]

, 2009
Nucleoporin Nup62 localizes at the central channel of the nuclear pore complex and is essential for nucleocytoplasmic transport. Through its FG-repeat domain, Nup62 regulates nuclear pore permeability and binds nuclear transport receptors.
Bayliss, Bayliss, Bernad, Blower, Boyd, Bradford, Brown, Buss, Caswell, Cho, Clarkson, Dawlaty, De Corte, Dultz, Frey, Grindstaff, Gromley, He, Hsu, Inoue, Jeganathan, Joseph, Joseph, Kalverda, Kasper, Kawase, Kawato, Kirsh, Lee, Liu, Loiodice, Macaulay, Matunis, Melcak, Moore, Munson, Nagai, Orjalo, Oztan, Palancade, Palancade, Paschal, Pommereit, Prigent, Rabut, Rittmeyer, Rosse, Sakurai-Yageta, Schrader, Schwarz-Herion, Stewart, Taddei, Tayeb, Terry, Towbin, Van Impe, Wang, Ward, Yeaman, Zimmermann, Zuccolo, Zuo   +61 more
core   +1 more source

Sphingosine kinase 1 serves as a pro-viral factor by regulating viral RNA synthesis and nuclear export of viral ribonucleoprotein complex upon influenza virus infection.

PLoS ONE, 2013
Influenza continues to pose a threat to humans by causing significant morbidity and mortality. Thus, it is imperative to investigate mechanisms by which influenza virus manipulates the function of host factors and cellular signal pathways. In this study,
Young-Jin Seo, Curtis J Pritzl, Madhuvanthi Vijayan, Kavita Bomb, Mariah E McClain, Stephen Alexander, Bumsuk Hahm   +6 more
doaj   +1 more source

RXRα acts as a carrier for TR3 nuclear export in a 9-cis retinoic acid-dependent manner in gastric cancer cells [PDF]

, 2004
Retinoid X receptor (RXR) plays a crucial role in the cross talk between retinoid receptors and other hormone receptors including the orphan receptor TR3, forming different heterodimers that transduce diverse steroid/thyroid hormone signaling.
Chen, HZ, Lin, SC, Lin, XF, Wu, Q, Yang, CY, Ye, XF, Zhang, MQ, Zhao, BX, Zhou, HY, 吴乔, 林圣彩   +10 more
core   +1 more source